2022
DOI: 10.1371/journal.pone.0261370
|View full text |Cite
|
Sign up to set email alerts
|

Curcumin suppresses tumorigenesis by ferroptosis in breast cancer

Abstract: Breast cancer (BC) is one of the most common malignant tumors found in females. Previous studies have demonstrated that curcumin, which is a type of polyphenol compound extracted from Curcuma longa underground rhizome, is able to inhibit the survival of cancer cells. However, the functional role and mechanism of curcumin in BC are still unclear. The Cell Counting Kit-8 assay was performed to examine the effects of curcumin on cell viability in the BC cell lines MDA-MB-453 and MCF-7. The levels of lipid reactiv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
36
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 58 publications
(38 citation statements)
references
References 39 publications
2
36
0
Order By: Relevance
“…Based on data from the literature [ 54 , 55 , 56 , 57 ], we decided to use curcumin as a naturally derived HO-1 inducer to explore the possible mechanism of HO-1 from a different perspective, which excluded the involvement of the exogenous substrate. Thus, curcumin can be considered as an inducer of ferroptosis in MDA-MB 231, in agreement with the results obtained by Cao et al [ 58 ]. The effects of the two ferroptosis inducers on mitochondrial dysfunction and lipid ROS accumulation were assessed fluorometrically by measuring lipid ROS accumulation with BODIPY 665/676 and mitochondrial dysfunction via a JC-1 assay.…”
Section: Discussionsupporting
confidence: 92%
“…Based on data from the literature [ 54 , 55 , 56 , 57 ], we decided to use curcumin as a naturally derived HO-1 inducer to explore the possible mechanism of HO-1 from a different perspective, which excluded the involvement of the exogenous substrate. Thus, curcumin can be considered as an inducer of ferroptosis in MDA-MB 231, in agreement with the results obtained by Cao et al [ 58 ]. The effects of the two ferroptosis inducers on mitochondrial dysfunction and lipid ROS accumulation were assessed fluorometrically by measuring lipid ROS accumulation with BODIPY 665/676 and mitochondrial dysfunction via a JC-1 assay.…”
Section: Discussionsupporting
confidence: 92%
“…Metformin triggers ferroptosis via a reduction in the UFMylation of SLC7A11 in breast cancer [98]. Curcumin promotes the ferroptosis of breast cancer cells by increasing lipid ROS levels, lipid peroxidation end-product MDA accumulation, and intracellular free iron levels [99]. Targeted exosome-encapsulated erastin promotes the ferroptosis of triple-negative breast cancer (TNBC) cells [100].…”
Section: Breast Cancermentioning
confidence: 99%
“…Since curcumin nanoparticles suppress ferroptosis, they can be used to strengthen the treatment of ICH [129]. Curcumin also induces the ferroptosis of breast cancer cells by upregulating SLC1A5 [99].…”
Section: Regulatory Effects Of Food-borne Active Ingredients On Ferro...mentioning
confidence: 99%
“…Evasion of anti-growth signaling Deguelin [34] Luteolin [35] Withaferin A [36,37] Curcumin [38] EGFR-p-AKT/c-Met p-ERK AKT/mTOR pathway Notch2 SLC1A5-mediated ferroptosis…”
Section: Cell Cycle Cell Cyclementioning
confidence: 99%