Curcumin targets miR-134-5p to suppress the progression of colorectal cancer through regulating the CDCA3/CDK1 pathway

Fu, Liu; Zhu, Changqing; Ma, Hui; Yang, Qian

doi:10.1007/s00210-023-02584-5

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Liu F et al reported that the administration of curcumin significantly suppressed the size of xenograft tumors. Mechanistic exploration determined that curcumin can target miR-134-5p expression and regulate the CDCA3/CDK1 pathway, thereby inhibiting proliferation in CRC ( Liu et al, 2023 ). Additionally, Other authors have established a zebrafish transplantation model and demonstrated that dendrobium polysaccharides, astragalus polysaccharides, and shiitake mushroom polysaccharides can effectively inhibit the growth of HT29 cells.…”

Section: Application Of Components In Crcmentioning

confidence: 99%

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Sun,

Wei,

Wang

et al. 2024

Front. Pharmacol.

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Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately 35% of patients at the time of diagnosis. Currently, chemotherapy has been used to improve patient prognosis and increase overall survival. However, chemotherapy can also have cytotoxic effects and lead to adverse reactions, such as inhibiting bone marrow hematopoiesis, causing digestive dysfunction, hand-foot syndrome, and even life-threatening conditions. In response to these adverse effects, researchers have proposed using Traditional Chinese Medicine (TCM) as an option to treat cancer. TCM research focuses on prescriptions, herbs, and components, which form essential components of the current research in Chinese medicine. The study and implementation of TCM prescriptions and herbs demonstrate its distinctive holistic approach to therapy, characterized by applying multi-component and multi-target treatment. TMC components have advantages in developing new drugs as they consist of single ingredients, require smaller medication dosages, have a precise measure of pharmacodynamic effects, and have a clear mechanism of action compared to TCM prescriptions and herbs. However, further research is still needed to determine whether TMC components can fully substitute the therapeutic efficacy of TCM prescriptions. This paper presents a comprehensive analysis of the research advancements made in TCM prescriptions, herbs, and components. The findings of this study can serve as a theoretical basis for researchers who are interested in exploring the potential of TCM for the treatment of colorectal cancer.

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Section: Application Of Components In Crcmentioning

confidence: 99%

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Sun,

Wei,

Wang

et al. 2024

Front. Pharmacol.

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Role of cell division cycle-associated proteins in regulating cell cycle and promoting tumor progression

Wang,

Ren,

Liu

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Utilizing an In-silico Approach to Pinpoint Potential Biomarkers for Enhanced Early Detection of Colorectal Cancer

Gharebaghi,

Afshar,

Tapak

et al. 2024

Cancer Inform

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Objectives: Colorectal cancer (CRC) is a prevalent disease characterized by significant dysregulation of gene expression. Non-invasive tests that utilize microRNAs (miRNAs) have shown promise for early CRC detection. This study aims to determine the association between miRNAs and key genes in CRC. Methods: Two datasets (GSE106817 and GSE23878) were extracted from the NCBI Gene Expression Omnibus database. Penalized logistic regression (PLR) and artificial neural networks (ANN) were used to identify relevant miRNAs and evaluate the classification accuracy of the selected miRNAs. The findings were validated through bipartite miRNA-mRNA interactions. Results: Our analysis identified 3 miRNAs: miR-1228, miR-6765-5p, and miR-6787-5p, achieving a total accuracy of over 90%. Based on the results of the mRNA-miRNA interaction network, CDK1 and MAD2L1 were identified as target genes of miR-6787-5p. Conclusions: Our results suggest that the identified miRNAs and target genes could serve as non-invasive biomarkers for diagnosing colorectal cancer, pending laboratory confirmation.

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Curcumin targets miR-134-5p to suppress the progression of colorectal cancer through regulating the CDCA3/CDK1 pathway

Cited by 5 publications

References 48 publications

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Treatment of colorectal cancer by traditional Chinese medicine: prevention and treatment mechanisms

Role of cell division cycle-associated proteins in regulating cell cycle and promoting tumor progression

Utilizing an In-silico Approach to Pinpoint Potential Biomarkers for Enhanced Early Detection of Colorectal Cancer

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