Curcumin: The active compound in turmeric has the potential to reduce pain intensity and increase range of motion during exercise-induced muscle damage

Abstract

This study aims to analyze and prove the effect of curcumin on pain intensity and ROM during EIMD. This experimental study used a pre and post-control group design. Research subjects were selected using a purposive sampling technique and then the subjects were divided into 2 groups, namely the group given a placebo and the group was given curcumin at a dose of 400 mg. A total of 24 healthy men aged between 20-30 years participated in this study. On the first day, all subjects took data on the characteristics of research subjects, then warmed up. Then the subjects did the high-intensity physical exercise in the form of squad and leg press exercises with an intensity of 80-90% of maximum ability. The exercise was carried out in 4 sets for each form of exercise and rest between sets for about 1 minute. On the second day, after 24 hours the subject took pre-test data to measure pain intensity and ROM, then the intervention was given based on each group. On the third day, after 24 hours the subject took post-test data to measure pain intensity and ROM. Measurement of pain intensity using the Visual Analytical Scale (VAS) and measurement of ROM performed in the knee joint using a goniometer. After the data was obtained, the data were analyzed using the IBM SPSS version 26 application. The results of this study reported that the group given curcumin during EIMD was able to significantly reduce pain intensity (*p<0.05) compared to the group given a placebo. Furthermore, the group given curcumin during EIMD was able to increase ROM significantly (*p<0.05) compared to the placebo group. We believe that the main cause of muscle soreness is the uncontrolled increase in pro-inflammatory cytokines such as TNF-a and IL-6 during EIMD and then decreased ROM for several days after exercise. Since pain intensity and ROM are needed to support body functions, we highly recommend the use of curcumin, which has many positive benefits for sports enthusiasts to support physical performance. Keywords: Curcumin, Pain Intensity, Range of Motion, Exercise-Induced Muscle Damage, Inflammation

Phytochemical Compounds in Sea Cucumber Have the Potential to Reduce Oxidative Stress and Inflammation Due to Exercise: Systematic Review

“…Furthermore, EIMD and increased ROS will trigger inflammation and reach its peak 24-48 hours after exercise (Chang et al, 2021;Hung et al, 2021). The inflammatory response due to exercise triggers a decrease in muscle strength, (Ayubi, Kusnanik, Herawati, Muhammad, et al, 2023). In inflammatory situations, other myokines such as TNF-α and interleukin-10 IL-10 are also expressed (Porto et al, 2023;Volpe-Fix et al, 2023).…”

“…With physical activity, anaerobic and aerobic metabolism and energy requirements by active muscles increase (Taherkhani, Suzuki and Castell, 2020;Daniela et al, 2022). However, intense physical exercise can cause significant damage to skeletal muscle tissue leading to decreased muscle function performance (Ayubi, Kusnanik, Herawati, Muhammad, et al, 2023). To save muscle performance through the immune system, an increase in the pro-anti/inflammatory balance is carried out which allows muscle regeneration (Volpe-Fix et al, 2023).…”

Potential of Polyphenolic Compounds in Rosella Flowers on Reducing Oxidative Stress and Inflammation After Exercise: A Systematic Review

“…Oxidative stress occurs after exercise-induced muscle damage (EIMD) with increased reactive oxygen species (ROS) (Bindu, Mazumder & Bandyopadhyay, 2020). EIMD can cause pain or muscle loss during the first 12-72 hours after exercise (Ayubi et al, 2023). The inflammatory response due to EIMD triggers a decrease in muscle strength, decreased range of motion (ROM), delayed muscle soreness (DOMS), local swelling, and an increase in muscle proteins in the blood (creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin (Mb) (Jamurtas, 2018;Fern & Mielgo-ayuso, 2020).…”