Curcumin, the golden spice in treating cardiovascular diseases

Li, Hong; Sureda, Antoni; Devkota, Hari Prasad; Pittalà, Valeria; Barreca, Davide; Sanches-Silva, A.; Tewari, Devesh; Xu, Suowen; Nabavi, Seyed Mohammad

doi:10.1016/j.biotechadv.2019.01.010

Cited by 244 publications

(143 citation statements)

References 186 publications

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“…The same is true of the imidazole thiol-containing ovothiol (279,280) . In a similar vein, and although outwith our scope here, we note the potential of other antioxidant natural products such as curcumin (281)(282)(283)(284)(285)(286) .…”

Section: Oxidative Stressmentioning

confidence: 72%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

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Section: Oxidative Stressmentioning

confidence: 72%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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“…Interestingly, curcumin lowered the level of LDL-C and TG in patients at risk for CVD (Qin et al, 2017). Therapeutic efficacy and molecular targets of curcumin in cardiovascular diseases have been reviewed elsewhere (Li et al, 2019).…”

Section: B Terpenoidsmentioning

confidence: 99%

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

et al. 2019

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“…Curcuminoid treatment improved glycemic factors, hepatic function, and serum cortisol levels in subjects with overweight and impaired fasting glucose in a randomized double-blind placebo-controlled trial involving 80 overweight subjects [210]. Among curcuminoids, curcumin is the best characterized and studied; its antioxidant and antiinflammatory properties are therefore considered a multifunction phytochemical that can interact with multiple molecular targets, modulating cell growth, inflammation, and apoptosis signaling pathways (reviewed in [211]). Firstly studied for its beneficial properties in the gastrointestinal tract, it has been observed that curcumin has a beneficial role in chronic conditions such as intestinal dysmotility disorders and in the prevention and maintenance of remission of intestinal bowel disease (IBD), requiring long-time treatment [212].…”

Section: Red Yeast Ricementioning

confidence: 99%

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

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Marracino

Martino

et al. 2019

Oxidative Medicine and Cellular Longevity

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Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have been shown to be involved in the processes underlying atherosclerosis, and evidence has been accumulating for the crucial role of Notch receptors in regulating the functions of the diverse cell types involved in atherosclerosis onset and progression. Several classes of nutraceuticals have potential benefits for the prevention and treatment of atherosclerosis and CVDs, some of which could in part be due to their ability to modulate the Notch pathway. In this review, we summarize the current state of knowledge on the role of Notch in vascular health and its modulation by nutraceuticals for the prevention of atherosclerosis and/or treatment of related CVDs.

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Curcumin, the golden spice in treating cardiovascular diseases

Cited by 244 publications

References 186 publications

The biology of ergothioneine, an antioxidant nutraceutical

The biology of ergothioneine, an antioxidant nutraceutical

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

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