Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor

Um, Min Young; Yoon, Minseok; Kim, Minji; Jung, Jonghoon; Kim, Seonghui; Kim, Dae‐Ok; Cho, Suengmok

doi:10.1039/d2fo02087d

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…As evident from previous studies, other constituents of GT with sleep-promoting effects could downregulate the arousal-inducing effects. The delta activity is used as a sleep parameter to evaluate sleep intensity in NREMS [ 43 , 44 ]. This study confirmed that caffeine did not change the delta activity [ 11 ] and that caffeine, as well as GT, induces arousal-inducing effects without a change in the delta activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine

Kim

Yoon

et al. 2023

Nutrients

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Wakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly consumed through coffee. Although green tea (Camellia sinensis L.) contains high caffeine content like coffee, its arousal-inducing effects have not yet been studied. In the present study, we aimed to identify the arousal-inducing effect of GT during a chronic administration period (three weeks) using analysis of sleep architecture. Treatment with GT (1500 mg/kg) significantly elevated the sleep latency and wakefulness throughout the treatment period, and chronic administration of GT consistently maintained an increase in wakefulness for up to 3 h. During the treatment period, the arousal-inducing effect of GT (1500 mg/kg) occurred without any change in the tolerance phenomenon or withdrawal symptoms, similar to that observed with caffeine (25 mg/kg). GT (1500 mg/kg) containing 95.6 mg/kg of caffeine did not produce a better arousal-inducing effect than caffeine at 25 mg/kg. These results indicate that the arousal-inducing effect of GT persisted for three weeks without adverse effects and that GT can control the arousal-inducing effects of caffeine due to the hypnotic effects of its other constituents.

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Section: Discussionmentioning

confidence: 99%

Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine

Kim

Yoon

et al. 2023

Nutrients

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“…Moreover, the administration of curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) to mice in pentobarbital‐induced sleep test modulated H 1 R activity, enhanced sleep duration, and NREM duration. They also decreased sleep latency without altering the REM and delta activity (Um et al, 2022).…”

Section: Herbal Sleep‐inducing Medicinesmentioning

confidence: 99%

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Insomnia affects millions of people worldwide, prompting considerable interest in herbal remedies for its treatment. This review aims to assess the therapeutic potential of such remedies for insomnia by analyzing current scientific evidence. The analysis identified several herbs, including Rosmarinus officinalis, Crocus sativus, Rosa damascena, Curcuma longa, Valeriana officinalis, Lactuca sativa, Portulaca oleracea, Citrus aurantium, Lippia citriodora, and Melissa officinalis, which show promise in improving overall sleep time, reducing sleep latency, and enhancing sleep quality. These plants act on the central nervous system, particularly the serotonergic and gamma‐aminobutyric acid (GABA)ergic systems, promoting sedation and relaxation. However, further research is necessary to fully understand their mechanisms of action, optimal dosages, and treatment protocols. Combining herbal medicines with conventional treatments may offer an effective natural alternative for those seeking medication. Nevertheless, individuals should consult their healthcare provider before using herbal remedies for insomnia. While this review provides evidence supporting their use, additional high‐quality studies are needed to firmly establish their clinical efficacy.

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“…Furthermore, the administration of curcuminoids reduced sleep latency and increased NREMS frequency in wild-type mice, but this effect was absent in H1R knockout mice [19]. Thus, curcuminoids and their constituents from C. longa roots reduced sleep latency and increased sleep duration by enhancing the quantity of non-rapid eye movement sleep (NREMS) by acting as modulators of histamine H1 receptor in the pentobarbital-induced sleep test in mice, indicating their usefulness in treating insomnia [19,20]. Ishola et al investigated the effects of administering C. longa rhizome to mice at varying doses (100, 200 or 400 mg/kg, p.o.)…”

Section: Introductionmentioning

confidence: 99%

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

Meesakul,

Shea,

Wong

et al. 2023

Pharmaceuticals

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Diverse chemical messengers are responsible for maintaining homeostasis in the human body, for example, hormones and neurotransmitters. Various Hawaiian plant species produce compounds that exert effects on these messengers and the systems of which they are a part. The main purpose of this review article is to evaluate the potential effects of Hawaiian plants on reducing pain and anxiety and improving sleep and mood. A comprehensive literature search was conducted in SciFinder, PubMed, Science Direct, Scopus, Google Scholar, and Scientific Information Database between 2019 and 2023 to identify related articles. Results indicate that several Hawaiian plant species, such as M. citrifolia and P. methysticum, have medicinal properties associated with these effects. These plants have been used in traditional Hawaiian cultural practices for centuries, suggesting their potential to benefit human health and well-being. This review presents a comprehensive analysis of the available evidence concerning the potential impacts of Hawaiian plants on sleep, anxiety, mood, and pain.

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Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor

Abstract: Curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin), which are the major constituents of turmeric (Curcuma longa), have sleep-promoting effects in mice through blockade of histamine H1 receptors

Cited by 9 publications

References 32 publications

Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine

Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.

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