Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Panahi, Yunes; Khalili, Nahid; Sahebi, Ebrahim; Namazi, Soha; Reiner, Željko; Majeed, Muhammed; Sahebkar, Amirhossein

doi:10.1016/j.ctim.2017.05.006

Cited by 181 publications

(162 citation statements)

References 47 publications

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“…Previous studies (Panahi et al, ) showed that curcumin reduces serum uric acid levels after treatment period of 8 weeks. However, in the current study all curcumin treated groups showed elevated levels of uric acid compared to the normal and DM untreated groups, especially in the high‐dose and oral treatment groups.…”

Section: Discussionmentioning

confidence: 94%

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Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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Herbal remedies have been used for centuries to ameliorate complications of diabetes mellitus (DM). The aim of this study is to compare the effects of the oral curcumin supplement versus parenteral administration of turmeric extract on diabetic complications in a streptozocin (STZ) diabetic model. STZ DM rats received low and high doses turmeric extract intraperitoneally as well as oral curcumin. Curcumin and turmeric extracts significantly reduced blood glucose and creatinine levels, but not urea, and caused an increase in uric acid. Low dose improved liver enzymes, while higher dose and oral administration caused an increase in the ALT and AST. All groups showed an improvement in the serum cholesterol, while the triglycerides were not improved in the high and oral treatment. Histological evaluation showed islet cell protection. High‐dose injection showed almost intact renal corpuscles as well as tubular structures with minimal degeneration. Treatment showed limited protection of Liver tissue. Practical application Curcumin has been heavily marketed as a protective agent. The current study shows some potential risk of curcumin use. Oral and injectable curcumin should be used with caution. Turmeric extract and oral curcumin supplement showed protective effects on pancreatic, and renal structure and function. Although both did show some improvement in liver function, higher doses caused disturbance in liver enzymes and did not show histological evidence of liver tissue protection.

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Section: Discussionmentioning

confidence: 94%

“…Previous studies (Panahi et al, 2017) showed that curcumin reduces serum uric acid levels after treatment period of 8 weeks.…”

Section: (B)mentioning

confidence: 95%

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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“…After duplicate removal, 60 records were excluded, and 84 studies were screened on the basis of titles and abstracts. From 21 studies selected for full‐text screening, 14 studies were excluded because of different types of supplement (Cicero et al, ; Rahimi et al, ; Kocher et al, ; Tariq et al, ), patients without a diagnosis of MetS (Campos‐Cervantes et al, ; Chuengsamarn et al, ; Esmaily et al, ; Ismail et al, ; Panahi, et al, ; Panahi, et al, ), lack of desired variables (Campos‐Cervantes et al, ), and reporting duplicate data (A. Mohammadi et al, ). Seven studies fulfilled inclusion criteria for quantitative data synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…However, serum HDL‐C levels did not change, significantly (Qin et al, ). Curcumin can reduce lipid peroxidation (Panahi et al, ) and the risk of cardiovascular factors in patients with type 2 diabetes and dyslipidemia (Panahi et al, ). In another study, curcumin supplementation did not improve anthropometric indices, serum lipid profiles (except TC), systolic blood pressure (SBP), and diastolic blood pressure (DBP) in the patients with MetS (Saberi‐Karimian et al, ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Azhdari

Karandish

Mansoori

2019

Phytotherapy Research

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The finding of studies on the effect of curcumin extract on metabolic factor in patients with metabolic syndrome has had arguable results. This systematic review with meta‐analysis of randomized controlled trials (RCT) aimed to analyze the effect of curcumin/turmeric on metabolic factors in patients with metabolic syndrome. The PICO strategy was used to establish the guiding question of this review. Several databases for RCT were searched until September 2018. Of the 144 articles initially identified, seven trials met the eligibility criteria. A random‐effects model with a mean weight difference (WMD) and a 95% confidence interval was performed for quantitative data synthesis. Pooled estimates of WMD were calculated between intervention and control groups using random‐effects model in the presence of high level of heterogeneity between the studies. The results showed significant improvement of fasting blood glucose (p = 0.01), triglycerides (p < 0.001), high‐density lipoprotein cholesterol (p = 0.003), and diastolic blood pressure (p = 0.007) levels. Curcumin was not associated with a significant change in waist circumference measurement (p = 0.6) and systolic blood pressure level (p = 0.269). Curcumin supplementation improves some components of metabolic syndrome.

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“…24 Curcumin affects many signaling pathways that lead to multiple health benefits. 28 It has been shown to be of benefit in inflammatory conditions [29][30][31][32][33] for the treatment of kidney 34 and liver [35][36][37][38] disorders, metabolic syndromes, 39 diabetes, 40 atherosclerosis, 41,42 dyslipidemia, [43][44][45][46] anxiety and/or depression, 47,48 viral diseases, 49 drug toxicity, 50 musculoskeletal, 51,52 and ischemic injury, 53 as well as having antitumor 49,[54][55][56] and antioxidant actions. 57 Furthermore, curcumin has shown efficacy in the management of degenerative eye conditions.…”

Section: Herbal Medicine Strategymentioning

confidence: 99%

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

et al. 2019

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Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress‐inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

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Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Cited by 181 publications

References 47 publications

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

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