Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats

Zhou, Jie; Ni, Maowei; Liu, Xia; Ren, Zeming; Zheng, Zhong

doi:10.12659/msm.902859

Cited by 36 publications

(19 citation statements)

References 38 publications

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“…In addition, studies investigated the effect of curcumol in suppressing TGF- β 1 led to the decrease of epithelial-mesenchymal transition occurrence. Reports also show that curcumol may modulate inflammatory and enhanced angiogenesis, resulting in better wound healing [28–30]. Our findings demonstrated that curcumol and curcumin could inhibit the TGF- β 1/Smads signaling pathway too by reducing the mRNA expression levels of fibrotic factors α -SMA, Smad2/3 and TGF- β .…”

Section: Discussionsupporting

confidence: 66%

Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Liu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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E-Zhu (Curcuma zedoaria) is known as a classical traditional Chinese medicine and widely used in the treatment of cancers, cardiovascular disease, inflammation, and other diseases. Its main components include curcumol and curcumin, which have anti-inflammatory and antifibrosis effects. Here we established an in vitro inflammatory injury model by stimulating RAW246.7 cells with cigarette smoke extract (CSE) and detected the intervention effects of curcumin and curcumol on CSE-treated Raw246.7 macrophage cells to explore whether the two compounds inhibited the expression of inflammatory cytokines by inhibiting the NF-κB signaling pathway. We detected the antifibrosis effects of curcumin and curcumol via TGF-β1/Smads signaling pathways. The model of macrophage damage group was established by CSE stimulation. Curcumol and curcumin were administered to Raw246.7 macrophage cells. The efficacy of curcumol and curcumin was evaluated by comparing the activation of proinflammatory factors, profibrotic factors, and NF-κB and TGF-β1/Smads signaling pathway. In addition, CSE-treated group was employed to detect whether the efficacy of curcumol and curcumin was dependent on the NF-κB signaling via the pretreatment with the inhibitor of NF-κB. Our findings demonstrated that curcumol and curcumin could reduce the release of intracellular ROS from macrophages, inhibit the NF-κB signaling pathway, and downregulate the release of proinflammatory factor. Curcumol and curcumin inhibited the TGF-β1/Smads signaling pathway and downregulated the release of fibrotic factors. Curcumin showed no anti-inflammatory effect in CSE-treated cells after the inhibition of NF-κB. Curcumol and curcumin showed an anti-inflammatory effect by inhibiting the NF-κB signaling pathway.

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Section: Discussionsupporting

confidence: 66%

Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Liu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…In this study, VCN-2 accelerated diabetic wound healing through the VEGF signalling pathways. Similarly, Zhou et al [63] revealed that the angiogenesis of diabetic rat skin ulcers was accelerated by curcumol via VEGF pathways.…”

Section: Discussionmentioning

confidence: 98%

Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats

Tan

Arulselvan

et al. 2019

BMC Complement Altern Med

113

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BackgroundImpaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non–healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Vicenin-2 (VCN-2) has been reported to contain prospective anti-oxidant and anti-inflammatory properties that enhance cell proliferation and migration. Sodium Alginate (SA) is a natural polysaccharide that possesses gel forming properties and has biodegradable and biocompatible characteristics. Therefore, the objective of this study is to evaluate the effect of SA wound dressings containing VCN-2 on diabetic wounds.MethodsWounds were inflicted in type-1 diabetic-streptozotocin (STZ) induced male Sprague Dawley rats. Subsequently, relevant groups were topically treated with the indicated concentrations (12.5, 25 and 50 μM) of VCN-2 hydrocolloid film over the study duration (14 days). The control group was treated with vehicle dressing (blank or allantoin). Wounded tissues and blood serum were collected on 0, 7 and 14 days prior to sacrifice. Appropriate wound assessments such as histological tests, nitric oxide assays, enzyme-linked immunosorbent assays (ELISA) and immunoblotting assays were conducted to confirm wound healing efficacy in the in vivo model. One-way Analysis of Variance (ANOVA) was used for statistical analysis.ResultsResults showed that hydrocolloid film was recapitulated with VCN-2 enhanced diabetic wound healing in a dose-dependent manner. VCN-2 reduced pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), mediators (iNOS and COX-2), and nitric oxide (NO) via the NF-κB pathway. Data suggests that the VCN-2 film facilitated healing in hyperglycemic conditions by releasing growth factors such as (VEGF and TGF-β) to enhance cell proliferation, migration, and wound contraction via the VEGF and TGF-β mechanism pathways.ConclusionsThis study’s findings suggest that VCN-2 may possess wound healing potential since topical treatment with VCN-2 hydrocolloid films effectively enhanced wound healing in hyperglycemic conditions.

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“…Curcumol has been isolated from C. longa which is an imperative species of the genus Curcuma and is generally known as common turmeric. Curcumol was also extracted from the rhizome of C. aeruginosae that is effective for antiinflammatory and antioxidant activities [20]. C. aromatic, a well-known natural source of curcumol, has been reported for its antitumor and antimicrobial activities [21].…”

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

“…The summary of plants containing curcumol and biological activities are enlisted in Table 1. Figure 1 provides natural sources of curcumol including Astragali radix [36], C. aeruginosae [20], C. aromatica [21], C. kwangsiensis [22], C. longa [37], C. phaeocaulis [24], C. wenyujin [38], C. zedoary [28], Fructus gardenia [35], and C. trichosantha G. [39].…”

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

Curcumol: From Plant Roots to Cancer Roots

et al. 2019

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Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.

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Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats

Cited by 36 publications

References 38 publications

Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats

Curcumol: From Plant Roots to Cancer Roots

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Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats

Cited by 36 publications

References 38 publications

Curcumin and Curcumol Inhibit NF-κB and TGF-β1/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Curcumin and Curcumol Inhibit NF-κB and TGF-β1/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats

Curcumol: From Plant Roots to Cancer Roots

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Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells

Curcumin and Curcumol Inhibit NF-κB and TGF-β₁/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells