CURE multicenter randomized, prospective trial of gold probe vs. Injection &amp; gold probe for hemostasis of bleeding peptic ulcers

Dm, Jensen; Kovacs, T; Jutabha, Rome; Machicado, Gustavo A.; Savides, TJ; Smith, James; Cheng, Su-Ting; Jensen, ME; Gornbein, Jeffrey; King, John W.

doi:10.1016/s0016-5107(97)80272-6

Cited by 3 publications

(9 citation statements)

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“…For example, the combination of injection therapy with another method of hemostasis (e.g., hemoclips or heat probe) outperforms injection alone for controlling bleeding, particularly high-risk bleeding [ 7 , 8 ]. However, therapeutic gain of contact thermal therapy and injection therapies may display no more hemostatic benefits than contact thermal monotherapy does [ 9 ]. Because contact thermal therapy, such as heat probe, exerts a tamponade effect on the artery, coaptivity coagulates the tissue, activates arterial coagulation, and causes edema that compresses the artery, and it has similar hemostatic efficacy to combined therapy [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the rate of peptic ulcer rebleeding was relatively low (3.4%) in the combined group, even though those patients did not receive high-dose PPI therapy. A lower incidence of Forrest grades IIa and IIb than other clinical trials may contribute to this phenomenon [ 7 – 9 , 11 ]. No significant difference existed between the two treatment groups in terms of need for surgery, need for blood transfusion, hospital stay, and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…For example, hemoclips combined with injection therapy outperform either hemoclips or injection therapy alone [ 7 , 8 ]. Injection therapy combined with heat probe treatment outperforms injection therapy alone but does not differ significantly from heater probe therapy alone [ 9 ]. This is probably because heat probe coagulation exerts a tamponade effect via direct contact [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Hemostatic Efficacy of Argon Plasma Coagulation with and without Distilled Water Injection in Treating High-Risk Bleeding Ulcers

Hsu

Wang

et al. 2014

BioMed Research International

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Background. Argon plasma coagulation (APC) is useful to treat upper gastrointestinal bleeding, but its hemostatic efficacy has received little attention. Aims. This investigation attempted to determine whether additional endoscopic injection before APC could improve hemostatic efficacy in treating high-risk bleeding ulcers. Methods. From January 2007 to April 2011, adult patients with high-risk bleeding ulcers were included. This investigation compared APC plus distilled water injection (combined group) to APC alone for treating high-risk bleeding ulcers. Outcomes were assessed based on initial hemostasis, surgery, blood transfusion, hospital stay, rebleeding, and mortality at 30 days posttreatment. Results. Totally 120 selected patients were analyzed. Initial hemostasis was accomplished in 59 patients treated with combined therapy and 57 patients treated with APC alone. No significant differences were noted between these groups in recurred bleeding, emergency surgery, 30-day mortality, hospital stay, or transfusion requirements. Comparing the combined end point of mortality plus the failure of initial hemostasis, rebleeding, and the need for surgery revealed an advantage for the combined group (P = 0.040). Conclusions. Endoscopic therapy with APC plus distilled water injection was no more effective than APC alone in treating high-risk bleeding ulcers, whereas combined therapy was potentially superior for patients with poor overall outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Hemostatic Efficacy of Argon Plasma Coagulation with and without Distilled Water Injection in Treating High-Risk Bleeding Ulcers

Hsu

Wang

et al. 2014

BioMed Research International

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“…Intervention on lesions with active bleeding, a visible vessel or adherent clot should be undertaken. Treatment of active bleeding has been shown to be well treated with combination therapy of adrenaline injection (diluted with saline 1:10000) and thermal coagulation (8,9). However, in the treatment of lesions with a visible vessel, combination treatment has not been shown to be more effective than using thermal coagulation alone (8,9).…”

Section: Review Of Gib Managementmentioning

confidence: 99%

“…Treatment of active bleeding has been shown to be well treated with combination therapy of adrenaline injection (diluted with saline 1:10000) and thermal coagulation (8,9). However, in the treatment of lesions with a visible vessel, combination treatment has not been shown to be more effective than using thermal coagulation alone (8,9). There is ongoing debate regarding the ideal management of lesions with an adherent clot (10)(11)(12)(13).…”

Section: Review Of Gib Managementmentioning

confidence: 99%

Management of Acute Bleeding Upper GI Ulcers in the Era of Endoscopic and IV PPI Therapy

Ilnyckyj

Mathew²

2005

Canadian Journal of Gastroenterology

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Therapeutic Endoscopy for Nonvariceal Gastrointestinal Bleeding

Kay

Wyllie

2007

J. pediatr. gastroenterol. nutr.

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The evaluation and management of acute gastrointestinal bleeding in infants, children, and adolescents is a reason for emergency consultation frequently cited by pediatric gastroenterologists. After stabilization of the patient's condition, endoscopic evaluation remains the most rapid and accurate method to identify the origin of acute bleeding in the majority of lesions in the pediatric age group. Several endoscopic techniques may be applied to bleeding lesions to achieve hemostasis. Familiarity with the various techniques and with the specifics of their use is essential for the pediatric endoscopist. This review focuses on the endoscopic management of acute nonvariceal bleeding in infants and children.

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CURE multicenter randomized, prospective trial of gold probe vs. Injection & gold probe for hemostasis of bleeding peptic ulcers

Cited by 3 publications

References 0 publications

Comparison of Hemostatic Efficacy of Argon Plasma Coagulation with and without Distilled Water Injection in Treating High-Risk Bleeding Ulcers

Comparison of Hemostatic Efficacy of Argon Plasma Coagulation with and without Distilled Water Injection in Treating High-Risk Bleeding Ulcers

Management of Acute Bleeding Upper GI Ulcers in the Era of Endoscopic and IV PPI Therapy

Therapeutic Endoscopy for Nonvariceal Gastrointestinal Bleeding

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