Cure of Helicobacter pylori Infection Improves Gastric Acid Secretion in Patients with Corpus Gastritis

Abstract

Gastric acid secretion increased into the normal range after successful treatment of H. pylori infection, suggesting that gastric function can recover to normal or almost normal after cure of H. pylori infection.

Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro‐oesophageal reflux disease in Western patients with non‐ulcer dyspepsia

“…18,19 In contrast, patients with corpus-predominant gastritis have decreased acid secretion, which tends to return to normal when eradication therapy is administered. 20,21 Increased delivery of acid to the duodenum has been shown to be associated with dyspeptic symptoms and patients with dyspepsia are hypersensitive to acid. 22 Our hypothesis was that the restoration of acid secretion seen in patients with severe corpus-predominant gastritis who undergo successful eradication would increase the risk of symptoms by increasing acid delivery to the duodenum and increase the risk of erosive oesophagitis.…”

The time to eradicate gastric cancer is now

“…For example, H pylori eradication in those with hypochlorhydria is expected to eliminate inflammation induced suppression of the remaining parietal cells. Therefore, even thought no new parietal cells may be produced, intragastric pH would be expected to fall, which will be reflected in a fall in gastrin 17 levels [37][38][39][40] as well as reduction in overgrowth by non-H pylori in the stomach. Those with complete atrophy would not be expected to experience any change in pH or overgrowth such that comparisons might include those whose gastrin remains elevated compared with those in whom it returns to normal.…”

Helicobacter pylori Infection, Gastric Physiology and Micronutrient deficiency (Iron and Vitamin C) in Children in Developing Countries

“…The low acid secretion, despite increased gastrin levels, indicates markedly impaired ability of oxyntic mucosa to secret acid in response to gastrin. Following eradication of H. pylori infection in patients with this pattern of gastritis, there is recovery in acid secretion [36,37]. However, the degree of recovery in acid outputs is variable -acid output resumes to normal level in some patients while very small increase occur in others [36].…”

“…In such subjects, acid secretion is reduced or completely absent (achlorhydria) [36,37]. The low acid secretion, despite increased gastrin levels, indicates markedly impaired ability of oxyntic mucosa to secret acid in response to gastrin.…”