Cure rate estimation and long-term prognosis of uterine cervix carcinoma

Pejovic, M.H.; Wolff, J. P.; Kramar, Andrew; Goldfarb, E.

doi:10.1002/1097-0142(19810101)47:1<203::aid-cncr2820470133>3.0.co;2-l

Cited by 15 publications

(6 citation statements)

References 4 publications

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“…Conversely, the importance of stage fell noticeably when allowance was made for the presence of lymph-node involvement. In agreement with Lee et al (1981) our study does not support earlier findings of a worse prognosis associated with a poorly differentiated histological grade (Stanhope et al 1980;Chung et al 1981), with adenocarcinoma rather than squamous carcinoma (Pejovic et al 1981) (though the numbers are too limited to draw any firm conclusions on this item) or with pregnancy (Stone et al 1965).…”

Section: Discussionsupporting

confidence: 82%

Invasive cervical cancer in young women

Vecchia

Franceschi

Decarli³

et al. 1984

BJOG

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Summary. Between 1970 and 1979, 103 women below 35 years of age with invasive cervical cancer were treated at the First Obstetrics and Gynaecology Clinic of the University of Milan. Nine patients were pregnant or less than 3 months postpartum. Estimated 10–year disease–free survival, determined by the life–table method, was 100% in stage IA (37 patients), 79% in stage IB (45 patients), 67% in stage 11 (15 patients), 0% in stages III (5 patients) and IV (1 patient). Prognosis was also strongly associated with lymph–node involvement, 10–year actuarial survival decreasing from 93% in lymph–node–negative to 44% in lymph–node– positive patients (P

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Section: Discussionsupporting

confidence: 82%

Invasive cervical cancer in young women

Vecchia

Franceschi

Decarli³

et al. 1984

BJOG

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“…The prognosis of adenocarcinoma was not poorer than that of squamous cell carcinoma. This finding contrasts with studies reporting that adenocarcinoma of the cervix has a worse prognosis than squamous cell carcinoma( 8, 29), which has been ascribed to the fact that lymph node metastasis may develop earlier in adenocarcinoma than in squamous cell carcinoma. In our study, we could not demonstrate that lymph node metastasis was more common in adenocarcinoma ( 4, 8).…”

Section: Discussioncontrasting

confidence: 99%

The significance of cell type and tumor growth markers in the prognosis of unscreened cervical cancer patients

Harmsel¹,

Muyden²,

Smedts³

et al. 1998

Int J Gynecol Cancer

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ter Harmsel B, van Muyden R, Smedts F, Hermans J, Kuijpers J, Raikhlin N, Petrov S, Lebedev A, Ramaekers F, Trimbos B. The significance of cell type and tumor growth markers in the prognosis of unscreened cervical cancer patients. Int J Gynecol Cancer 1998; 8: 336–344. The clinical significance of p53, Ki‐67‐Ag, and BCL‐2 as markers for patient prognosis in cervical carcinoma was compared to established prognostic tumor parameters. The examined population consisted of 159 unscreened Russian women, presenting with Stage I (n= 74) and Stage II (n= 85) cervical carcinoma. Relevant clinical information was available in all cases. Thirty‐five percent of cases were either adenocarcinoma or contained an adenocarcinomatous component. Lymph node status and stage of disease appeared to be statistically significant parameters for patient survival. Depth of tumor infiltration was a significant indicator of 5‐year relapse risk, while tumor size and histologic classification were not predictive. When analyzed separately, p53, Ki‐67‐Ag, and BCL‐2 were not significantly correlated with clinical parameters. However, high Ki‐67‐Ag combined with high BCL‐2 indices predicted a shorter relapse‐free interval than did low Ki‐67‐Ag combined with low BCL‐2 index. We conclude that the relatively high incidence of cervical adenocarcinomas is merely due to an increased awareness in the histologic classification criteria of this tumor subtype. Furthermore, histologic parameters are not of value in predicting patient outcome. Although tumor stage and lymph node status are superior to individual markers of tumor growth and genomic instability in determining patient prognosis, a combination of markers for proliferation index and protection from apoptotic cell death shows a tendency to predict clinical outcome.

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“…As expected, two DNA bands of 6.2 and 5.0 kb were observCervical cancers are treated by surgery, radiation and cytotoxic drugs (Friedlander et al, 1983;Haie et al, 1988;McGuire et al, 1989). Treatment depends on prognosis which is determined by clinicopathological parameters of which the most important are clinical stage at diagnosis and nodal status (Pejovic et al, 1981). However in most cases, cervical cancers respond poorly to chemotherapy.…”

Section: Resultssupporting

confidence: 58%

Expression of anionic glutathione S transferase (GSTπ) gene in carcinomas of the uterine cervix and in normal cervices

Riou

Barrois²,

Zhou³

1991

Br J Cancer

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SummaryThe aim of the present study was to analyse in invasive carcinomas of the uterine cervix, the anionic glutathione S transferase (GSTi) gene, possibly implicated in the drug resistance of human cancers. Total RNA preparations obtained from invasive cervical cancers (106 specimens), carcinomas in situ (CIS) (three specimens) and normal cervical epitheliums (24 specimens) were analysed by Northern (Pastan & Gottesman, 1987;Moscow & Cowan, 1988;Endicott & Ling, 1989;D'Arpa & Liu, 1989;Beck, 1989;Giovanella et al., 1989;Tew, 1989 (Beck, 1989;Giovanella et al., 1989). Another mechanism of action involving glutathione S transferase was described in cancer cells resistant to drugs as different as cis-platinum, alkylating agents and anthracyclines (Tew, 1989). The anionic isoenzyme glutathione S transferase (GSTx) which belongs to a complex group of drug-detoxifying enzymes, was present at high levels in the MCF7 breast cancer cell line resistant to Doxorubicine (DXR) together with high levels of MDRI transcripts (Batist et al., 1986;. Although the precise role of GST7 in the development of resistance is not known, its expression may be one among the numerous phenotypic and biochemical changes which accompany drug resistance in some cancers.Patients with invasive carcinoma of the uterine cervix are treated by surgery, radiation and/or chemotherapy (Friedlander et al., 1983;McGuire et al., 1989 Materials and methodsCervical cancers and normal cervical epitheliums One hundred and six specimens of invasive cervical cancer were obtained by biopsy or rarely by surgical excision from untreated patients (93 primary tumours and 5 node metastases) and from treated patients (six recurrent tumours and two liver metastases). These treated patients have received external beam radiotherapy (RX) and/or drug regimen (DR) composed of cis-platinum, Methotrexate, Chlorambucil and Vincristine (Table I). Three specimens of carcinoma in situ (CIS) were also obtained at surgery. Specimens of normal cervical epithelium were obtained from 18 patients treated by surgery for fibroma of the uterine corpus and from six patients with adjacent primary cervical cancers. Tumour and cell samples were immediately stored in liquid nitrogen.DNA and RNA preparations DNAs and total RNAs were prepared from the same tissue samples (about 100 mg) by the guanidinium isothiocyanateCsCl gradient method (Maniatis et al., 1982;Sheng et al., 1990

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Cure rate estimation and long-term prognosis of uterine cervix carcinoma

Cited by 15 publications

References 4 publications

Invasive cervical cancer in young women

Invasive cervical cancer in young women

The significance of cell type and tumor growth markers in the prognosis of unscreened cervical cancer patients

Expression of anionic glutathione S transferase (GSTπ) gene in carcinomas of the uterine cervix and in normal cervices

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