Curiethérapie préopératoire des adénocarcinomes de l'endomètre de stades cliniques I–II : résultats à dix ans d'une série de 780 patientes

Hoffstetter, S.; Brunaud, C.; Marchal, C.; Luporsi, É.; Guillemin, François; Leroux, A; Bey, P.; Peiffert, D.

doi:10.1016/j.canrad.2004.02.001

Cancer/Radiothérapie

2004

DOI: 10.1016/j.canrad.2004.02.001

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Curiethérapie préopératoire des adénocarcinomes de l'endomètre de stades cliniques I–II : résultats à dix ans d'une série de 780 patientes

S. Hoffstetter

C. Brunaud

C. Marchal

et al.

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Cited by 2 publications

References 38 publications

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The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Kebaïli¹,

K²,

Louati³

et al. 2015

Integr Cancer Sci Therap

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To study the epidemiological, clinical, paraclinical and therapeutic caracteristics of this cancer in south Tunisia population, a retrospective descriptive and analytic study was conducted over a period of 12 years from January 1993 until December 2004 on 52 patients carrying endometrial cancer. Diagnosis and therapeutic management were made in the departments of Obstetrics and Gynecology University Hospital HediChaker of Sfax and radiotherapy at the University Hospital Habib Bourguiba of Sfax. The average age of patients was 57.53 years. Menopause was observed in 76.92% cases. Hypertension, obesity and diabetes were observed, respectively, in 40.38%, 26.92% and 11.53% of cases. The mean delay of consulting was 8 months. Uterine bleeding was observed in 98.07% cases. Endometrial b iopsy curettage or directed biopsy was performed in 50 women (96.15%) including 35 women under hysteroscopy. Histopathological examination was conclusive in 46 patients (92%) Adenocarcinoma was the most frequent histological type found in 39 cases (84.78%). Physical examination under general anesthesia was carried out for 44 patients it was normal in 77.27% of cases. The magnetic resonance imaging was performed in 3 patients. Stage I and II were the most observed stages. Preoperative brachytherapy was achieved only in 30 women. Surgery was indicated in 49 cases (94.23%). Thirty three patients (63.46%) received supplemental external radiotherapy. Overall survival at 5 years was 66.8%. Endometrial cancer in associated with many risk factors it must be evoked in front of any abnormal bleeding in aged women. Endometrial biopsy curettage performed under hysteroscopy allows the diagnosis in most cases. Magnetic resonance imaging allows tumorstaging. Treatment is based on the triade brachytherapy, surgery and external post operative radiotherapy. Chemotherapyis added in the therapeutic arsenal in high recidive risk tumor.

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The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Kebaïli¹,

K²,

Louati³

et al. 2015

Integr Cancer Sci Therap

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Management of inoperable endometrial cancer

2022

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Some endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant treatment before surgery. Radiation therapy alone (of different modes) has been used as the sole definitive therapeutic modality, particularly for early-stage disease that is limited to the uterine body and cervix with or without parametrial invasion. The most common treatment modality is neoadjuvant treatment before surgery. Postoperative adjuvant treatment is also occasionally used, depending mainly on the sites of the disease and the results of surgery. Data on neoadjuvant hormonal or radiation therapy are limited, with studies focusing on laboratory outcomes or having only a small number of patients. Most neoadjuvant treatments before surgery involved chemotherapy and fewer combined chemoradiotherapy. Surgery was generally performed, particularly in patients who had shown responses or at least stable disease to neoadjuvant treatment. Perioperative outcomes after neoadjuvant treatment were superior to those after primary surgery, whereas survival data were still inconsistent. Features that had or tended to have a favorable prognosis were younger age, early-stage disease, response to neoadjuvant treatment, low preoperative cancer antigen-125 level, and optimal surgery. Among different modalities of neoadjuvant treatment, which has become a frequent mode of treatment, neoadjuvant chemotherapy was more common than radiation therapy alone or chemoradiation.

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Curiethérapie préopératoire des adénocarcinomes de l'endomètre de stades cliniques I–II : résultats à dix ans d'une série de 780 patientes

Cited by 2 publications

References 38 publications

The endometrial cancer in Southern Tunisia: Investigation about 52 cases

The endometrial cancer in Southern Tunisia: Investigation about 52 cases

Management of inoperable endometrial cancer

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