Curing Necrotic Angiodermatitis with an Intact Fish Skin Graft in a Patient Living with Diabetes

Dardari, D.; Lequint, Corinne; Jugnet, Anne Christine; Bénard, Tatiana; Bouly, Marie; Penfornis, A.

doi:10.3390/medicina58020292

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Therefore, full-thickness grafts should be used in areas significantly impacted aesthetically or functionally with scarring or scar contractures, such as the head and neck, hands, genitals, or breasts. Current investigations into methods to reduce the initial contraction and subsequent need for contracture release include initial mechanical restraint immediately after grafting as well as the application of topical agents to delay keratinocyte differentiation or prevent crossling formation (Dardari et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of skin natural change function in split-thickness skin graft

Limarda¹,

Jeser²,

Andrew³

et al. 2022

midwifery

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Treatment for severe burns has improved rapidly in the last 20 years. Nowadays, patients can survive with burns covering up to approximately 90% of the body, although they often face permanent physical impairment. This type of research is a literature review. A literature review was conducted to gather information regarding the evaluation of skin natural change function in the split-thickness skin graft. This research is a type of review article that aims to obtain information about acne based on bio-markers. Source of data used secondary sources. The method of data collection through collecting data was from research articles taken within the last five years. Skin grafting remains an essential step on the reconstructive surgeon ladder. Meanwhile, the basic premise has remained similar results over the years. New techniques and devices have contributed to significantly improved functional and aesthetic results. Advances in the production of skin substitutes have provided better options to treat patients and will continue to be an essential and dynamic component of this field in the future.

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Section: Resultsmentioning

confidence: 99%

Evaluation of skin natural change function in split-thickness skin graft

Limarda¹,

Jeser²,

Andrew³

et al. 2022

midwifery

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“…The iFSGs are available in several sizes, shapes and variations, including pre-meshed or granulated products in the U.S. market, while the European CE certification of those pre-meshed and granulated products, as well as of larger fish skin grafts, is still pending. The clinical spectrum of iFSGs has been reported in several case reports up to prospective randomized-controlled trials and involves typical and atypical chronic wounds and traumatic wounds, including burns in adult and pediatric patients [ 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts

Dueppers,

Bozalka,

Kopp

et al. 2023

JCM

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Background: Necrotizing fasciitis (NF) is a serious infectious disease that can initially place the patient’s life in danger and, after successful surgical and antibiotic treatment, leaves extensive wounds with sometimes even exposed bones and tendons. Autologous skin grafts are not always possible or require adequate wound bed preparation. Novel intact fish skin grafts (iFSGs; Kerecis® Omega3 Wound, Kerecis hf, Isafjördur, Iceland) have already shown their potential to promote granulation in many other wound situations. Faster wound healing rates and better functional and cosmetic outcomes were observed due to their additionally postulated anti-inflammatory and analgesic properties. Therefore, iFSGs may also be essential in treating NF. We present our initial experience with iFSGs in treating leg wounds after NF and review the literature for the current spectrum of clinical use of iFSGs. Case Presentations: We present two male patients (aged 60 and 69 years) with chronic or acute postsurgical extensive leg ulcers six weeks and six days after necrotizing fasciitis, respectively. Both suffered from diabetes mellitus without vascular pathologies of the lower limbs. A single application of one pre-meshed (Kerecis® Graftguide) and one self-meshed 300 cm2 iFSG (Kerecis® Surgiclose) was performed in our operation room after extensive surgical debridement and single circles of negative wound pressure therapy. Application and handling were easy. An excellent wound granulation was observed, even in uncovered tibia bone and tendons, accompanied by pain relief in both patients. Neither complications nor allergic reactions occurred. The patients received autologous skin grafting with excellent functional and cosmetic outcomes. Conclusions: iFSGs have the potential to play a significant role in the future treatment of NF due to the fast promotion of wound granulation and pain relief. Our experience may encourage surgeons to use iFSGs in NF patients, although high-quality, large-sized studies are still required to confirm these results. The observed effects of iFSGs on wounds associated with NF may be transferred to other wound etiologies as well.

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“…Due to these beneficial wound healing properties, Omega-3-rich AFS may be used in a broad spectrum of applications: Recent studies report good clinical outcomes after application in, e.g., chronic diabetic foot ulcers [ 13 ], calciphylaxis wounds [ 14 ], necrotic angiodermatitis [ 15 ], iatrogenic calcinosis cutis [ 16 ] or even for neovaginoplasty in patients with Mayer-Rokitansky-Küster-Hauser syndrome [ 17 ]. AFS may also present an effective treatment option in burn wound management, since studies indicate accelerated wound healing, pain reduction, decrease in necessary dressing changes as well as treatment-related costs [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

et al. 2022

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Background and Objectives: Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development of acellular fish skin. Acellular fish skin acts as a skin substitute, reducing inflammatory responses and advancing proinflammatory cytokines that promote wound healing. Due to these beneficial wound healing properties, acellular fish skin might represent an effective treatment approach in burn wound management. Materials and Methods: A systematic review of the literature, up to March 2022, was conducted using the electronic databases PubMed and Web of Science. Titles and abstracts were screened for the following key terms (variably combined): “fish skin”, “fish skin grafts”, “acellular fish skin”, “Omega3 Wound matrix”, “xenograft”, “burn injury”, “burns”. Results: In total, 14 trials investigating the effects of acellular fish skin in burn wounds or split-thickness donor sites were determined eligible and included in the present review. Existing evidence on the use of acellular fish skin indicates an acceleration of wound healing, reduction in pain and necessary dressing changes as well as treatment-related costs and improved aesthetic and functional outcomes compared to conventional treatment options. Conclusions: Acellular fish skin xenografts may represent an effective, low-cost alternative in treatment of superficial- and partial-thickness burns. However, results mainly originate from preclinical and small cohort studies. Future larger cohort studies are warranted to elucidate the full potential of this promising approach.

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Curing Necrotic Angiodermatitis with an Intact Fish Skin Graft in a Patient Living with Diabetes

Cited by 8 publications

References 17 publications

Evaluation of skin natural change function in split-thickness skin graft

Evaluation of skin natural change function in split-thickness skin graft

The Use of Intact Fish Skin Grafts in the Treatment of Necrotizing Fasciitis of the Leg: Early Clinical Experience and Literature Review on Indications for Intact Fish Skin Grafts

The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review

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