We present the reweighting of two sets of nuclear PDFs, nCTEQ15 and EPPS16, using a selection of experimental data on heavy-flavor meson [D 0 , J/ψ, B → J/ψ and Υ(1S )] production in proton-lead collisions at the LHC which were not used in the original determination of these nuclear PDFs. The reweighted PDFs exhibit significantly smaller uncertainties thanks to these new heavy-flavor constraints. We present a comparison with another selection of data from the LHC and RHIC which were not included in our reweighting procedure. The comparison is overall very good and serves as a validation of these reweighted nuclear PDF sets,which we dub nCTEQ15 rwHF & EPPS16 rwHF . This indicates that the LHC and forward RHIC heavy-flavor data can be described within the standard collinear factorization framework with the same (universal) small-x gluon distribution. We discuss how we believe such reweighted PDFs should be used as well as the limitations of our procedure.