Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Fakhri, Sajad; Moradi, Seyed Zachariah; Faraji, Farahnaz; Farhadi, Tara; Hesami, Osman; Iranpanah, Amin; Webber, Kassidy; Bishayee, Anupam

doi:10.1007/s10555-023-10119-w

Cancer Metastasis Rev

2023

DOI: 10.1007/s10555-023-10119-w

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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Sajad Fakhri,

Seyed Zachariah Moradi,

Farahnaz Faraji

et al.

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2024

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Cited by 4 publications

References 495 publications

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Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

Mondal,

Banerjee,

Terang

et al. 2024

Phytotherapy Research

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Cancer profoundly influences morbidity and fatality rates worldwide. Patients often have dismal prognoses despite recent improvements in cancer therapy regimens. However, potent biomolecules derived from natural sources, including medicinal and dietary plants, contain biological and pharmacological properties to prevent and treat various human malignancies. Capsaicin is a bioactive phytocompound present in red hot chili peppers. Capsaicin has demonstrated many biological effects, including antioxidant, anti‐inflammatory, antimicrobial, and anticarcinogenic capabilities. This review highlights the cellular and molecular pathways through which capsaicin exhibits antineoplastic activities. Our work also depicts the synergistic anticancer properties of capsaicin in conjunction with other natural bioactive components and approved anticancer drugs. Capsaicin inhibits proliferation in various cancerous cells, and its antineoplastic actions in numerous in vitro and in vivo carcinoma models impact oncogenesis, tumor‐promoting and suppressor genes, and associated signaling pathways. Capsaicin alone or combined with other phytocompounds or approved antineoplastic drugs triggers cell cycle progression arrest, generating reactive oxygen species and disrupting mitochondrial membrane integrity, ultimately stimulating caspases and promoting death. Furthermore, capsaicin alone or in combination can promote apoptosis in carcinoma cells by enhancing the p53 and c‐Myc gene expressions. In conclusion, capsaicin alone or in combination can have enormous potential for cancer prevention and intervention, but further high‐quality studies are needed to firmly establish the clinical efficacy of this phytocompound.

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Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

Mondal,

Banerjee,

Terang

et al. 2024

Phytotherapy Research

Self Cite

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Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment

Banerjee,

Bishayee

et al. 2024

Phytomedicine

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Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

de Pellegars-Malhortie,

Picque Lasorsa,

Mazard

et al. 2024

Pharmaceuticals

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Despite significant progress in cancer prevention, screening, and treatment, the still limited number of therapeutic options is an obstacle towards increasing the cancer cure rate. In recent years, many efforts were put forth to develop therapeutics that selectively target different components of the oncogenic Wnt/β-catenin signaling pathway. These include small molecule inhibitors, antibodies, and more recently, gene-based approaches. Although some of them showed promising outcomes in clinical trials, the Wnt/β-catenin pathway is still not targeted in routine clinical practice for cancer management. As for most anticancer treatments, a critical limitation to the use of Wnt/β-catenin inhibitors is their therapeutic index, i.e., the difficulty of combining effective anticancer activity with acceptable toxicity. Protecting healthy tissues from the effects of Wnt/β-catenin inhibitors is a major issue due to the vital role of the Wnt/β-catenin signaling pathway in adult tissue homeostasis and regeneration. In this review, we provide an up-to-date summary of clinical trials on Wnt/β-catenin pathway inhibitors, examine their anti-tumor activity and associated adverse events, and explore strategies under development to improve the benefit/risk profile of this therapeutic approach.

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Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

Cited by 4 publications

References 495 publications

Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression

Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment

Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

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