Current advances in radiotherapy for soft tissue sarcomas

Spałek, Mateusz; Borkowska, Aneta

doi:10.5603/njo.2020.0056

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Radiation therapy should be considered after MDT to decrease the local recurrence rate. Currently hypofractionated preoperative RT may be advised [87,88]. Referral to a sarcoma center for hypofractionated radiotherapy with hyperthermia may be considered in patients with marginally resectable or unresectable ES and in patients who are not eligible for chemotherapy [89].…”

Section: Discussionmentioning

confidence: 99%

Epithelioid sarcoma

Czarnecka

2023

Nowotwory. Journal of Oncology

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Epithelioid sarcoma (ES) is a very rare sarcoma characterized by loss of INI1. Enzinger first described ES in 1970, but the histopathologic differential diagnosis of ES remains challenging. There are two ES subtypes, the classical type with spindle epithelioid to the central pseudogranulomatous cells, and the proximal type, which is predominantly composed of epithelioid and rhabdoid cells. ES symptoms and signs are not specific and depend on tumor localization. The only treatment for ES is radical excision with a microscope-radical margin. In general, the best treatment for ES in extremes is radical resection with a wide margin or amputation with or without lymph node dissection. Surgery may be followed by adjuvant chemotherapy and/or radiation therapy. Referral of patients with ES to a sarcoma center that offers hypofractionation RT trials and multidisciplinary clinical trials should be considered upfront. Neoadjuvant chemotherapy with ifosfamide and doxorubicin with / or without radiation therapy must be used after a multidisciplinary team discussion. On 23 January 2020, the US Food and Drug Administration (FDA) first approved tazemetostat -an inhibitor of zeste homolog 2 enhancer -therapy for metastatic ES or locally advanced ES not eligible for radical resection.

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Section: Discussionmentioning

confidence: 99%

Epithelioid sarcoma

Czarnecka

2023

Nowotwory. Journal of Oncology

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“…The guidelines of the American Society for Radiation Oncology (ASTRO) for the first time recommended preoperative over postoperative radiotherapy in patients without significant factors for impaired wound healing after resection [110][111][112][113][114]. Locally advanced MPNST, including radiation-induced MPNST should be treated, if possible, within prospective clinical trials based on combined conventionally fractionated or hypofractionated radiotherapy with systemic treatment or other methods increasing local effectiveness such as hyperthermia [115][116][117]. It is important to consider the higher risk of inducing secondary neoplasms after radiotherapy in the course of NF1, which is particularly important in the case of the group of young patients treated with a radical intention [118].…”

Section: Perioperative Treatmentmentioning

confidence: 99%

Recommendations of the Polish Sarcoma Group on diagnostic-therapeutic procedures and control in patients with type 1 neurofibromatosis (NF1) and the associated malignant neoplasm of peripheral nerve sheaths

Rutkowski

Raciborska²,

Szumera‐Ciećkiewicz

et al. 2022

Nowotwory. Journal of Oncology

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.According to the authors, this elaboration contains the most justified principles of diagnostic-therapeutic procedures. They should, however, be interpreted in relation to the particular clinical situation. The recommendations do not always correspond to the current bases of refunding treatment in force in Poland (which is noted in the text). In the case of doubt, the current possibilities of refunding particular procedures should be ascertained.

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Current advances in radiotherapy for soft tissue sarcomas

Cited by 2 publications

References 55 publications

Epithelioid sarcoma

Epithelioid sarcoma

Recommendations of the Polish Sarcoma Group on diagnostic-therapeutic procedures and control in patients with type 1 neurofibromatosis (NF1) and the associated malignant neoplasm of peripheral nerve sheaths

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