Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal

Jarosz, Maciej; Keppler, Bernhard K.; Timerbaev, Andrei R.

doi:10.1007/s00216-021-03718-5

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…After explaining the financial components that must be considered when purchasing an MS system, it is unavoidable to calculate the return on investment [76,77]. Insignificant operating expenses in comparison to intimidating initial costs could ultimately be used as an excuse, together with an argument that currently there is no alternative in the market [78,79]. To evaluate the cost-effectiveness and return on investment, when deciding on investing in a new MS instrument, the price of an MS instrument, as well as all other (recurring) costs, should be considered (i.e., service contract, reagents, consumables, etc.).…”

Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2023

Preprint

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The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. Moreover, today’s appliances are so handy, that they literally place a whole lab on a single chip. Methods of OMICS (and the most recently developed term OMICS 2.0) are tackled, having in mind their aptness for educational purposes, as well as their feasibility. This same topic was highlighted in many reviews that have been periodically published. The author’s initial interest was the forensic application of MS, but since these interests changed, terms such as “biosensors” were also examined, so the review included means of discovery of efficient biomarkers and clinical therapeutic targets. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically studied. Since the topic of generating permanent collections of digital content for retrospective analysis was also reviewed, the need for loads of data – cloud storage was discussed in the context of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay. In this manner, the review has strengthened an in-depth understanding of the applications of MS.

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Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2023

Preprint

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“…After explaining the financial components that must be considered when purchasing an MS system, it is unavoidable to calculate the return on investment [71,72]. Insignificant operating expenses in comparison to intimidating initial costs could ultimately be used as an excuse, together with an argument that currently there is no alternative in the market [73,74].…”

Section: Feasibilitymentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2022

Preprint

View full text Add to dashboard Cite

The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. These methods were discussed, and their feasibility was highlighted in many reviews that have been periodically published, in addition to the most recently developed term OMICS 2.0. This author’s primary interest was the forensic application of MS, but since these interests got broadened, terms such as “biosensors” were also included. So, means of discovery of efficient biomarkers and clinical therapeutic targets were also reviewed. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically scoped. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. Since the topic of generating permanent collections of digital content for retrospective analysis was reviewed, what requires loads of data – cloud storage is discussed in the context of MS. In this manner, the review has strengthened an in-depth understanding of the applications of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay.

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“…The analysis of chemical elements in clinical or biological samples gained eminent attention, due to their essential roles in life science, clinical diagnostics, and drug development and drug-effect monitoring [ 1 , 2 , 3 , 4 , 5 ]. Particularly in body fluids, such as serum or cerebrospinal fluid, as well as in tissue samples, the content of chemical elements, the specific element binding forms (element species), their redox state under specific health or pathologic conditions, as well as their spatial distribution in tissue of pathological interest, or even in single cells, are the focus of research today.…”

Section: Introductionmentioning

confidence: 99%

Review about Powerful Combinations of Advanced and Hyphenated Sample Introduction Techniques with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) for Elucidating Trace Element Species in Pathologic Conditions on a Molecular Level

Michalke

2022

IJMS

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Element analysis in clinical or biological samples is important due to the essential role in clinical diagnostics, drug development, and drug-effect monitoring. Particularly, the specific forms of element binding, actual redox state, or their spatial distribution in tissue or in single cells are of interest in medical research. This review summarized exciting combinations of sophisticated sample delivery systems hyphenated to inductively coupled plasma-mass spectrometry (ICP-MS), enabling a broadening of information beyond the well-established outstanding detection capability. Deeper insights into pathological disease processes or intracellular distribution of active substances were provided, enabling a better understanding of biological processes and their dynamics. Examples were presented from spatial elemental mapping in tissue, cells, or spheroids, also considering elemental tagging. The use of natural or artificial tags for drug monitoring was shown. In the context of oxidative stress and ferroptosis iron, redox speciation gained importance. Quantification methods for Fe2+, Fe3+, and ferritin-bound iron were introduced. In Wilson’s disease, free and exchangeable copper play decisive roles; the respective paragraph provided information about hyphenated Cu speciation techniques, which provide their fast and reliable quantification. Finally, single cell ICP-MS provides highly valuable information on cell-to-cell variance, insights into uptake of metal-containing drugs, and their accumulation and release on the single-cell level.

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Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal

Cited by 4 publications

References 45 publications

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Review about Powerful Combinations of Advanced and Hyphenated Sample Introduction Techniques with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) for Elucidating Trace Element Species in Pathologic Conditions on a Molecular Level

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