“…The evolving nature of the HIV pandemic, dynamic shifts in drug use patterns, criminalization of drug use, and other HIV risk behaviors, along with the use of new technologies and other rapid advances in treatment and prevention, create continuously changing ethical challenges for HIV research involving people who use and abuse drugs and other vulnerable populations (Loue & Pike, 2010). Advocates for the human rights of drug users and international organizations championing the rights of vulnerable populations affected by the HIV pandemic have found common cause in urging investigators, funders, and ethics review committees to give greater attention to the development of HIV prevention research ethics policies and practices that are sensitive to the discrimination, stigmatization, police harassment, and social marginalization experienced by persons who use drugs (Centers for Disease Control and Prevention [CDC], 2013; Deren et al, 2011; Des Jarlais et al, 2013; Fisher, 2004; Joint United Nations Programme on HIV/AIDS [UNAIDS], 2013). Addressing such challenges requires investigators with both knowledge of and ability to generate empirical data that can enhance practices and policies directed at protecting the rights and welfare of participants in HIV/drug abuse prevention studies.…”