Current and emerging treatments for vitiligo

Rodrigues, Michelle; Ezzedine, Khaled; Hamzavi, Iltefat; Pandya, Amit G.; Harris, John E.

doi:10.1016/j.jaad.2016.11.010

Cited by 159 publications

(210 citation statements)

References 87 publications

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“…It affects 0·5–1% of the world's population and has significant effects on quality of life . Unfortunately, there are currently no treatments approved by the U.S. Food and Drug Administration to induce repigmentation of affected areas . Rapidly progressive disease has been shown to respond to systemic corticosteroids; however, this treatment is associated with a high incidence of side‐effects when given continuously .…”

Section: Results At the First Follow‐up Evaluationmentioning

confidence: 99%

Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo

et al. 2018

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Section: Results At the First Follow‐up Evaluationmentioning

confidence: 99%

Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo

et al. 2018

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“…1,2 Treatment options include non-surgical interventions, such as phototherapy and topical agents, 3 and various surgical interventions. 4 However, not all vitiligo lesions respond to the conventional treatments; 5 acral vitiligo (which is very noticeable) especially is often resistant to even surgical interventions. 6 Camouflage may be a viable alternative for patients with refractory vitiligo that has not responded to surgical intervention, and for those who are not candidates for surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Micropigmentation for vitiligo on light to moderately colored skin: Updated evidence from a clinical and animal study

Eun

Lee

et al. 2020

The Journal of Dermatology

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Micropigmentation, also termed medical tattooing, can be a useful alternative treatment for patients with vitiligo who are resistant to conventional treatments. To assess the benefits and risks of micropigmentation in the treatment of refractory vitiligo, 25 lesions of 14 patients with vitiligo (Fitzpatrick skin types III and IV) were subjected to micropigmentation using an electric tattooing machine between December 2018 and March 2019. The procedure was repeated until satisfactory results were obtained. Treatment response was assessed by color matching of the treated lesion and surrounding skin using a 4-point scale (poor, fair, good and excellent). Excellent color matching was achieved in 80% (20/25) of cases after a median of three (range, 1-5) treatment sessions. Procedure-associated pain was considerable, but no anesthetic injection was needed. Immediate erythema and swelling were noticed after each procedure, but resolved within a few days. Overall, the treatment was tolerable. This study was limited by a small sample, no control group and a short follow-up period. This study revealed that micropigmentation was beneficial for patients with refractory vitiligo who had light to moderately colored skin. Pigment selection, implantation depth and selection of body parts amenable to treatment were critical.

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“…The mechanism of depigmentation is considered to be closely related to immune imbalance, which results in related enzyme inhibition and melanocyte destruction (Boniface, ; Frisoli & Harris, ; Vachiramon, Chaiyabutr, & Rattanaumpawan, ). Conventional treatments are long and ineffective, potentially leading to emotional and psychological problems in vitiligo patients (Mohammad, Silpa‐Archa, Griffith, Lim, & Hamzavi, ; Rodrigues et al, ). At present, CO2 fractional laser therapy is a new and more effective method to treat vitiligo, with studies showing that a CO2 fractional laser can promote pigment regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional treatments are long and ineffective, potentially leading to emotional and psychological problems in vitiligo patients (Mohammad, Silpa-Archa, Griffith, Lim, & Hamzavi, 2017;Rodrigues et al, 2017). At present, CO2 fractional laser therapy is a new and more effective method to treat vitiligo, with studies showing that a CO2 fractional laser can promote pigment regeneration.…”

mentioning

confidence: 99%

Effects of CO2 Fractional Laser Therapy on Peripheral Blood Cytokines in Patients with Vitiligo

et al. 2019

Dermatologic Therapy

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Vitiligo is a disease pathologically characterized by specific damage to melanocytes. The aim of this study was to explore the mechanism underlying CO2 fractional laser treatment of vitiligo by detecting the levels of Th1 cytokines (IL‐2 and IFN‐γ), Th2 cytokines (IL‐4 and IL‐10), and Th17 cytokines (IL‐17 and IL‐23) in peripheral blood. Twenty five vitiligo patients were enrolled in this study and were treated with a CO2 fractional laser four to eight times. The cytokines of 25 vitiligo patients and 20 healthy volunteers were measured by enzyme‐linked immunosorbent assay. After CO2 fractional laser therapy, six cases were cured, and the apparent efficiency was 72.0% (18/25), while the efficiency was 92.0% (23/25). Before CO2 fractional laser therapy, IL‐2 and IFN‐γ levels in vitiligo patients were higher than those in the control group, but the difference was not statistically significant (p > .05). IL‐4, IL‐10, IL‐17, and IL‐23 levels were also higher in vitiligo patients than those in the control group (p < .05). After treatment, IL‐2 and IFN‐γ levels in vitiligo patients were lower than before treatment, but the difference was not statistically significant (p > .05), while IL‐4, IL‐10, IL‐17, and IL‐23 levels were significantly lower compared with before treatment (p < .05). The results show that CO2 fractional laser treatment has a good curative effect in the treatment of vitiligo.

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Current and emerging treatments for vitiligo

Cited by 159 publications

References 87 publications

Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo

Addition of oral minipulse dexamethasone to narrowband ultraviolet B phototherapy and topical steroids helps arrest disease activity in patients with vitiligo

Micropigmentation for vitiligo on light to moderately colored skin: Updated evidence from a clinical and animal study

Effects of CO2 Fractional Laser Therapy on Peripheral Blood Cytokines in Patients with Vitiligo

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