Current and emerging trends in polymeric 3D printed microfluidic devices

González, Gustavo; Roppolo, Ignazio; Pirri, Candido; Chiappone, Annalisa

doi:10.1016/j.addma.2022.102867

Cited by 77 publications

(74 citation statements)

References 258 publications

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“…Given the fact that it allows for building complex structures with customized geometries in a simple, fast, and low-cost manner, 3D printing has increasingly been regarded as an advantageous method for producing microfluidic platforms. Compared to traditional manufacturing techniques, 3D printing offers a flexible fabricating alternative with fewer steps, suitable for rapid prototyping, while also enabling on-demand production of parts from different materials with high microscale precision [ 2 , 90 , 91 , 92 , 93 , 94 ]. Moreover, the flexibility of direct 3D printing also facilitates linking micromixer modules, increasing the versatility and functionality of final devices [ 37 , 95 , 96 ].…”

Section: Geometriesmentioning

confidence: 99%

“…Microfluidic technology has attracted increasing scientific interest in the last decades, gaining attention for numerous applications, especially in the fields of chemistry and biology [ 1 , 2 ]. Based on the use of miniaturized devices with channels and chambers of tens to hundreds of micrometers, microfluidic technology enables highly precise fluid manipulation.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Niculescu

Mihăiescu

Grumezescu

2022

IJMS

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Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels and chambers. Such microfluidic systems can be used for numerous applications, including reactions, separations, or detection of various compounds. Therefore, due to their potential as microreactors, a particular research focus was noted in exploring various microchannel configurations for on-chip chemical syntheses of materials with tailored properties. Given the significant number of studies in the field, this paper aims to review the recently developed microfluidic devices based on their geometry particularities, starting from a brief presentation of nanoparticle synthesis and mixing within microchannels, further moving to a more detailed discussion of different chip configurations with potential use in nanomaterial fabrication.

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Section: Geometriesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Niculescu

Mihăiescu

Grumezescu

2022

IJMS

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“…18 More importantly, due to the ever-improving resolution of 3D printers, 3D printing technology allows the fabrication of microuidic devices with true micro-scale channel dimensions (#20 mm), progressing closer to the conventional technologies such as so lithography. 21,22 Numerous exciting 3D-printed microuidics have been recently reported. 16,23 Some of the examples of 3D printed microuidics that have been developed include electrodes for electroanalytical analyses, 24 3D cell culture microuidic devices, 25 droplet-based microuidics, 26 gradient generators, 27 as well as transparent and quantitative microuidic devices for sample analyses.…”

Section: Introductionmentioning

confidence: 99%

“…18 More importantly, due to the ever-improving resolution of 3D printers, 3D printing technology allows the fabrication of microfluidic devices with true micro-scale channel dimensions (≤20 μm), progressing closer to the conventional technologies such as soft lithography. 21,22…”

Section: Introductionmentioning

confidence: 99%

Emerging 3D printing technologies and methodologies for microfluidic development

2022

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“…3D printing is one of the disruptive technologies in the micro uidics eld. It speeds up the molding fabrication and makes it feasible for direct micro uidic fabrication without polymer casting, owing to the high availability of the various resin types in the market [19][20][21][22][23]. Among the number of distinctive printing techniques, such as laser sintering, fused lament, and an inkjet-based 3D printer, resin stereolithography emanates as a potential fabrication pathway of 3D printing because of its high resolution, good surface nishing, and considerably low expenses per printed device.…”

Section: Introductionmentioning

confidence: 99%

Versatile and low-cost fabrication of modular lock-and-key micro-fluidics for integrated connector mixer using a stereolithography 3D printing

Anshori

Lukito

Adhawiyah³

et al. 2022

Preprint

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We present a low-cost and simple method to fabricate microfluidic modules directly on a submillimeter scale utilizing an economic stereolithography (SLA) three-dimensional (3D) printer, which only costs less than 400 USD for the investment. The proposed study is promising for a high throughput fabrication module, typically limited by conventional microfluidic fabrications, such as photolithography and polymer casting methods. We demonstrate the two lock-and-key modular fluidic platforms for connector modules and chamber modules with optimized parameters, such as exposure condition and printing orientation. In addition, optimization of post-processing was performed to investigate the reliability of the fabricated hollow structures, which are fundamental to creating a fluidic channel or chamber. We found out that by using an inexpensive 3D printer, the fabricated resolution can be pushed down to 850 µm and 550 µm size for squared- and circled-shaped, respectively; by the gradual hollow structure, applying vertical printing orientation. These strategies opened up the possibility of developing straightforward microfluidic platforms that could replace conventional microfluidics mold fabrication methods, such as photolithography and milling, which are costly and time-consuming. Considerably cheap commercial resin and its tiny volume employed for a single printing procedure extremely cut down the estimated fabrication cost to less than 50 cents USD/module. The simulation study unravels the prominent properties of the fabricated devices for biological fluid mixers such as plasma blood. This study is eminently prospective toward microfluidics application in clinical biosensing, where disposable, low-cost, high-throughput, and reproducible chips are highly required.

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Current and emerging trends in polymeric 3D printed microfluidic devices

Cited by 77 publications

References 258 publications

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

Emerging 3D printing technologies and methodologies for microfluidic development

Versatile and low-cost fabrication of modular lock-and-key micro-fluidics for integrated connector mixer using a stereolithography 3D printing

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