Current and future prospective of biosensing molecules for point-of-care sensors for diabetes biomarker

Hatada, Mika; Wilson, Ellie D.; Khanwalker, Mukund; Probst, David; Okuda-Shimazaki, Junko; Sode, Koji

doi:10.1016/j.snb.2021.130914

Cited by 17 publications

(11 citation statements)

References 231 publications

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“…The construction of a smartphone-based portable glucose monitoring system needs the advances in multiple fields. Firstly, the fabrication of a miniaturized glucose sensor requires the combination of technologies in related fields, such as biology, material science, analytical chemistry and mechanical technology [ 73 ]. Secondly, the design of the electrochemical testing circuit is to simplify the circuit integrated in the bulky electrochemical workstation, just leaving the module for the specific electrochemical glucose electrode [ 74 , 75 , 76 , 77 ].…”

Section: Smartphone-based Portable Glucose Monitoringmentioning

confidence: 99%

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Yan

Liu

2022

Sensors

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As a vital biomarker, glucose plays an important role in multiple physiological and pathological processes. Thus, glucose detection has become an important direction in the electrochemical analysis field. In order to realize more convenient, real-time, comfortable and accurate monitoring, smartphone-based portable, wearable and implantable electrochemical glucose monitoring is progressing rapidly. In this review, we firstly introduce technologies integrated in smartphones and the advantages of these technologies in electrochemical glucose detection. Subsequently, this overview illustrates the advances of smartphone-based portable, wearable and implantable electrochemical glucose monitoring systems in diverse biofluids over the last ten years (2012–2022). Specifically, some interesting and innovative technologies are highlighted. In the last section, after discussing the challenges in this field, we offer some future directions, such as application of advanced nanomaterials, novel power sources, simultaneous detection of multiple markers and a closed-loop system.

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Section: Smartphone-based Portable Glucose Monitoringmentioning

confidence: 99%

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Yan

Liu

2022

Sensors

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“…The use of nanomaterials and microfluidics resulted in increased sensitivity of tests, holding a great promise as a future of more economical POC devices with even shorter turnaround time. A number of new highly pursued features of POC biosensors are being continuously developed and presented to the scientific community [ 194 ]. In a recently published review from Campuzano et al, the use of antibiofouling (antibiofouling polymers are being increasingly used in nanomedicine and macroscopic surface coatings, with poly(ethylene glycol) as the most widely-used polymer) [ 188 , 195 , 196 ], aptamer and biomolecular switches (molecular recognition receptors for electrochemical biosensors, with near real-time response) [ 188 , 197 ], next generation of amplification-free nucleic acid detection techniques (as an alternative to delicate and time-consuming rt-PCR, with immense importance in a resource-limited setting) [ 198 , 199 ] and other novel technologies are presented, with the main features that POC devices should comply with [ 188 ].…”

Section: Future Development and Outlookmentioning

confidence: 99%

Diagnostic Modalities in Critical Care: Point-of-Care Approach

et al. 2021

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The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding development progress in the last decades. Multidisciplinary care of critically ill patients has become an integral part of every modern health care system, ensuing improved care and reduced mortality. Early recognition of severe medical and surgical illnesses, advanced prehospital care and organized immediate care in trauma centres led to a rise of ICU patients. Due to the underlying disease and its need for complex mechanical support for monitoring and treatment, it is often necessary to facilitate bed-side diagnostics. Immediate diagnostics are essential for a successful treatment of life threatening conditions, early recognition of complications and good quality of care. Management of ICU patients is incomprehensible without continuous and sophisticated monitoring, bedside ultrasonography, diverse radiologic diagnostics, blood gas analysis, coagulation and blood management, laboratory and other point-of-care (POC) diagnostic modalities. Moreover, in the time of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, particular attention is given to the POC diagnostic techniques due to additional concerns related to the risk of infection transmission, patient and healthcare workers safety and potential adverse events due to patient relocation. This review summarizes the most actual information on possible diagnostic modalities in critical care, with a special focus on the importance of point-of-care approach in the laboratory monitoring and imaging procedures.

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“…Despite the relevance of GA as a glycemic biomarker, there are still no commercially available POC devices for its determination. Nevertheless, it is expected that due to its potential and the high incidence of T2DM, advances will be soon emerging [ 105 ]. The development of microfluidic platforms for GA determination has benefited from nanomaterials that eliminate the need for the use of chromogens and enzymes.…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…Despite the advances in these biomarkers, glucose continues to be one of the most studied as a model molecule for the development of sensors and POC devices. In addition, the devices for its determination are among the most advanced not only in the management of diabetes, but in general in the diagnostic area, it is also one of the only biomarkers with continuous monitoring devices clinically validated and available on the market [ 105 ].…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

2021

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A point-of-care (POC) can be defined as an in vitro diagnostic test that can provide results within minutes. It has gained enormous attention as a promising tool for biomarkers detection and diagnosis, as well as for screening of chronic noncommunicable diseases such as diabetes mellitus. Diabetes mellitus type 2 is one of the metabolic disorders that has grown exponentially in recent years, becoming one of the greatest challenges to health systems. Early detection and accurate diagnosis of this disorder are essential to provide adequate treatments. However, efforts to reduce incidence should remain not only in these stages but in developing continuous monitoring strategies. Diabetes-monitoring tools must be accessible and affordable; thus, POC platforms are attractive, especially paper-based ones. Paper-based POCs are simple and portable, can use different matrixes, do not require highly trained staff, and are less expensive than other platforms. These advantages enhance the viability of its application in low-income countries and hard-to-reach zones. This review aims to present a critical summary of the main components required to create a sensitive and affordable enzymatic paper-based POC, as well as an oriented analysis to highlight the main limitations and challenges of current POC devices for diabetes type 2 monitoring and future research opportunities in the field.

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Current and future prospective of biosensing molecules for point-of-care sensors for diabetes biomarker

Cited by 17 publications

References 231 publications

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Smartphone-Based Electrochemical Systems for Glucose Monitoring in Biofluids: A Review

Diagnostic Modalities in Critical Care: Point-of-Care Approach

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

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