Current and future role of double-lung transplantation for bilateral lung cancer

Lee, Jeeyeon; Schellenberg, Samuel; Chung, Liam Il-Young; Bharat, Ankit; Chae, Young Kwang

doi:10.1016/j.trre.2023.100772

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…41 Recent advancements in technology and survival of lung transplant could also selectively be applied to some patients. 42,43 The integration of liquid biopsy in PM has brought new insights into this field.…”

Section: Discussionmentioning

confidence: 99%

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The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

Woo,

Park,

Ahadi

et al. 2024

Preprint

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Introduction: Due to heterogeneous characteristics of primary cancers, the efficacy of pulmonary metastasectomy(PM) in non-primary lung cancers has not been investigated other than colorectal cancers. This study aims to investigate the clinical outcomes of PM for non-primary lung cancer. Methods: A systematic search for meta-analyses on PM for non-primary lung cancers was conducted, encompassing publications up to January 3, 2024. The analysis included seven primary cancer types: renal cell, breast, adrenocortical, head and neck cancers, melanoma, germ cell tumors, and sarcoma. Primary outcomes, overall survival, and recurrence rates post-PM were assessed using random-effect models to account for study heterogeneity. Results: This study included 16 systematic-review articles and 101 individual studies, involving 10,277 patients who underwent PM for non-primary lung cancer. Patients had a mean age of 48.0 years, with 68.4% being male. About half of the patients(47.1% [95%CI 40.8-53.5] presented with multiple metastatic lesions, and complete R0 resection achieved in 87.2% [95%CI 83.0-90.8]. The pooled 5-year overall survival (OS) rate post-PM was 41.2% [95%CI, 37.1-45.4%]. Patients with germ cell tumors demonstrated significantly higher survival rate than other cancers(p<0.05), while patients with melanoma exhibited the poorest outcome(p<0.05). During follow-up, 57.6%[95%CI 46.4-68.1] had recurrence; 48% of them had intrathoracic-only recurrence and 52% had extra-thoracic recurrence. Conclusion: This study underscores the survival benefits associated with PM. Overall survival rates following PM do not significantly differ based on primary cancer types, except for germ cell tumors and melanoma. These findings highlight the importance of recognizing and incorporating PM into clinical practice when appropriate.

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Section: Discussionmentioning

confidence: 99%

“…41 Recent advancements in technology and survival of lung transplant could also selectively be applied to some patients. 42,43…”

Section: Discussionmentioning

confidence: 99%

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

Woo,

Park,

Ahadi

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

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The Role of Pulmonary Metastasectomy for Non‐Primary Lung Cancer: Umbrella Review of Meta‐Analyses

Woo,

Park,

Ahadi

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesDue to heterogeneous characteristics of primary cancers, the efficacy of pulmonary metastasectomy (PM) in nonprimary lung cancers has not been investigated. This study aims to investigate the clinical outcomes of PM for non‐primary lung cancer.MethodsA systematic search for meta‐analyses on PM for nonprimary lung cancers was conducted, encompassing publications up to January 3, 2024. This included seven primary cancers: renal cell, breast, adrenocortical, head and neck cancers, melanoma, germ cell tumors, and sarcoma. Overall survival and recurrence rates post‐PM were assessed using random‐effect models.ResultsThis study included 16 systematic‐review articles and 101 individual studies, involving 10 277 patients who underwent PM for nonprimary lung cancer. About half of the patients (47.1%) presented with multiple metastasis, and complete resection achieved in 87.2% [95% CI: 83.0–90.8]. The pooled 5‐year overall survival rate post‐PM was 41.2% [95%CI: 37.1%–45.4%]. Patients with germ cell tumors demonstrated higher survival rate (p < 0.05), while melanoma exhibited the worst outcome (p < 0.05). During follow‐up, 57.6% [95% CI: 46.4–68.1] had recurrence; 48% of them had intrathoracic‐only recurrence.ConclusionThis study underscores the survival benefits associated with PM. Overall survival rates following PM did not differ based on primary cancer types. These findings highlight the importance of recognizing and incorporating PM into clinical practice when appropriate.

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Lung transplantation proposed as a cure for cancer

Pullen

2024

American Journal of Transplantation

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Current and future role of double-lung transplantation for bilateral lung cancer

Cited by 5 publications

References 78 publications

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses

The Role of Pulmonary Metastasectomy for Non‐Primary Lung Cancer: Umbrella Review of Meta‐Analyses

Lung transplantation proposed as a cure for cancer

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