Current and Future Technologies for the Detection of Antibiotic-Resistant Bacteria

Yamin, Dina; Uskoković, Vuk; Wakil, Abubakar; Goni, Mohammed; Shamsuddin, Shazana; Mustafa, Fatin; Alfouzan, Wadha; Alissa, Mohammed; Alshengeti, Amer; Almaghrabi, Rana; Fares, Mona; Garout, Mohammed; Al Kaabi, Nawal; Alshehri, Ahmad; Ali, Hamza; Rabaan, Ali; Aldubisi, Fatimah; Yean, Chan; Yusof, Nik

doi:10.3390/diagnostics13203246

Cited by 26 publications

(4 citation statements)

References 301 publications

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“…Incorporating machine learning techniques such as convolutional neural networks (CNNs) has significantly enhanced the speed and accuracy of diagnoses by automatically classifying imaging data based on computed parameters [ 29 ]. Additionally, emerging technologies such as thermography and electrical impedance tomography (EIT) provide non-invasive and radiation-free alternatives for early detection and risk assessment in conditions such as breast cancer [ 31 ]. While these innovative modalities offer promising applications, they also encounter specificity, resolution, and regulatory acceptance challenges.…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Ghosh Moulic,

Deshmukh,

Gaurkar

2024

Cureus

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Biofilms, structured communities of microorganisms encased in a self-produced matrix, pose significant challenges in otorhinolaryngology due to their role in chronic and recurrent infections affecting the ear, nose, and throat (ENT) region. This review provides an overview of biofilms, emphasizing their formation, pathogenesis, diagnosis, and treatment strategies in otorhinolaryngological disorders. Biofilms are pivotal in chronic rhinosinusitis (CRS), otitis media, laryngopharyngeal reflux (LPR), and tonsillitis, contributing to treatment resistance and disease recurrence. Current diagnostic techniques, including imaging modalities, microbiological cultures, and molecular techniques, are discussed, alongside emerging technologies. Treatment strategies, ranging from conventional antibiotics to alternative therapies, such as biofilm disruptors, phage therapy, and immunomodulation, are evaluated in terms of their efficacy and potential clinical applications. The review underscores the significance of understanding biofilms in otorhinolaryngology and highlights the need for tailored approaches to diagnosis and management to improve patient outcomes.

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Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Ghosh Moulic,

Deshmukh,

Gaurkar

2024

Cureus

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“…These tests are the first molecular tests for determining resistance to this drug (World Health Organization (WHO), 2021). However, healthcare professionals should have a clear understanding of the strengths and limitations of certain technologies in order to make informed decisions in fighting antibiotic resistance and improving patient outcomes (Kotze et al, 2020;Yamin et al, 2023).…”

Section: Antimicrobial Resistancementioning

confidence: 99%

Molecular Diagnostics for Infectious Diseases: Implications for Diagnosis and Management

Alyahyawi

2024

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Molecular diagnostics is an excellent tool used by healthcare management for infectious diseases to detect and manage infections. As such, many researchers have addressed the ideas surrounding the molecular diagnosis. This review explores the role of molecular diagnostics in managing and diagnosing infectious diseases, highlighting its potential to prevent catastrophic outcomes. The literature surrounding the historical aspects and the importance of molecular diagnostics in modern healthcare can help explain the role of the tool and how it can improve the patient's outcome and help the therapeutic decisions. In this literature review, databases are searched using relevant keywords to gather information on the role of molecular diagnostics in managing and diagnosing infectious diseases. The review highlights the significance of molecular diagnostics in detecting resistant strains and guiding evidence-based antimicrobial treatment to combat antimicrobial resistance. Furthermore, the review discusses how adopting new diagnostic approaches as standard practice in clinical departments introduces various subjects. The findings demonstrate that implementing molecular diagnostics in clinical settings reduces mortality rates, improves healthcare efficiency, and enhances public surveillance.

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“…Advances in molecular biology, genomics, proteomics, nanotechnology, and bioinformatics have paved the way for developing novel techniques that offer enhanced sensitivity, specificity, and rapidity in microbial identification and characterization. These innovative approaches hold immense promise for improving disease diagnosis, antibiotic stewardship, and AMR containment efforts [ 6 ]. This review article aims to provide a comprehensive overview of innovative paradigms in microbial detection and AMR surveillance, focusing on methods beyond traditional cultural approaches.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Innovative Paradigms in Microbial Detection and Antimicrobial Resistance: Beyond Traditional Cultural Methods

Ahmad,

Lohiya,

Taksande

et al. 2024

Cureus

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Microbial detection and antimicrobial resistance (AMR) surveillance are critical components of public health efforts to combat infectious diseases and preserve the efficacy of antimicrobial agents. While foundational in microbial identification, traditional cultural methods are often laborious, time-consuming, and limited in their ability to detect AMR markers. In response to these challenges, innovative paradigms have emerged, leveraging advances in molecular biology, genomics, proteomics, nanotechnology, and bioinformatics. This comprehensive review provides an overview of innovative approaches beyond traditional cultural methods for microbial detection and AMR surveillance. Molecular-based techniques such as polymerase chain reaction (PCR) and next-generation sequencing (NGS) offer enhanced sensitivity and specificity, enabling the rapid identification of microbial pathogens and AMR determinants. Mass spectrometry-based methods provide rapid and accurate detection of microbial biomarkers, including matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and biosensor technologies. Nanotechnology approaches, such as nanoparticle-based assays and nanopore sequencing, offer novel platforms for sensitive and label-free detection of pathogens and AMR markers. Embracing these innovative paradigms holds immense promise for improving disease diagnosis, antibiotic stewardship, and AMR containment efforts. However, challenges such as cost, standardization, and integration with existing healthcare systems must be addressed to realize the full potential of these technologies. By fostering interdisciplinary collaboration and innovation, we can strengthen our ability to detect, monitor, and combat AMR, safeguarding public health for generations.

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Current and Future Technologies for the Detection of Antibiotic-Resistant Bacteria

Cited by 26 publications

References 301 publications

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Molecular Diagnostics for Infectious Diseases: Implications for Diagnosis and Management

A Comprehensive Review of Innovative Paradigms in Microbial Detection and Antimicrobial Resistance: Beyond Traditional Cultural Methods

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