Current application and modification strategy of marine polysaccharides in tissue regeneration: A review

Wang, Zhaokun; Xu, Z.; Yang, Xuan; Li, Man; Yip, Ryan Chak Sang; Chen, Hao

doi:10.1016/j.bioadv.2023.213580

Cited by 18 publications

(8 citation statements)

References 529 publications

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“…[16] Agarose Consisting of alternating 1,3-linked β-D-galactose and 1,4-linked 3,6-anhydro-α-Lgalactose units Extracted from seaweed. [17] Dextran Composed of α-1, 6 glycosidic linkages between glucose monomers, with branches from α-1, 2, α-1, 3, and α-1, 4 linkages 1. Produced from slime-producing bacteria called Leuconostoc Lesenteroides; 2.…”

Section: Guar Gummentioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.

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Section: Guar Gummentioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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“…This section will review the literature data on the isolation of marine osteoactive compounds from 1999 to 2023. Note that only compounds with pharmacological applications will be presented here; marine-derived biomaterials with applications in bone regeneration, fracture healing, and tissue engineering will be overlooked since it has already been reviewed [ 163 – 166 ]. Our survey identified a total of 101 marine osteoactive compounds (Fig.…”

Section: Marine Natural Products As Alternative Players In Mbd Therap...mentioning

confidence: 99%

Metabolic bone disorders and the promise of marine osteoactive compounds

Carletti,

Gavaia,

Cancela

et al. 2023

Cell. Mol. Life Sci.

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Metabolic bone disorders and associated fragility fractures are major causes of disability and mortality worldwide and place an important financial burden on the global health systems. These disorders result from an unbalance between bone anabolic and resorptive processes and are characterized by different pathophysiological mechanisms. Drugs are available to treat bone metabolic pathologies, but they are either poorly effective or associated with undesired side effects that limit their use. The molecular mechanism underlying the most common metabolic bone disorders, and the availability, efficacy, and limitations of therapeutic options currently available are discussed here. A source for the unmet need of novel drugs to treat metabolic bone disorders is marine organisms, which produce natural osteoactive compounds of high pharmaceutical potential. In this review, we have inventoried the marine osteoactive compounds (MOCs) currently identified and spotted the groups of marine organisms with potential for MOC production. Finally, we briefly examine the availability of in vivo screening and validation tools for the study of MOCs.

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“…Polysaccharides are divided into land-and sea-based types, which are mainly derived from marine organisms that live in a saline buffer system with a specific water pressure, high salinity, low temperature, insufficient light source, and low dissolved oxygen. These unique environmental factors lead to differences in synthesis pathways between land-and sea-derived substances, and marine polysaccharides have a novel structure and special biochemical mechanism because of the beneficial environmental factors [29]. According to their sources, marine polysaccharides can be categorized as algal (classified as brown, red, and green algae according to pigment deposition), marine animal, and marine microbial polysaccharides.…”

Section: Marine Polysaccharidesmentioning

confidence: 99%

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

Liu,

Chen,

Chen

et al. 2023

Nutrients

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Hyperlipidemia (HLP) is a metabolic disorder caused by abnormal lipid metabolism. Recently, the prevalence of HLP caused by poor dietary habits in the population has been increasing year by year. In addition, lipid-lowering drugs currently in clinical use have shown significant improvement in blood lipid levels, but are accompanied by certain side effects. However, bioactive marine substances have been shown to possess a variety of physiological activities such as hypoglycemic, antioxidant, antithrombotic and effects on blood pressure. Therefore, the hypolipidemic efficacy of marine bioactive substances with complex and diverse structures has also attracted attention. This paper focuses on the therapeutic role of marine-derived polysaccharides, unsaturated fatty acids, and bioactive peptides in HLP, and briefly discusses the main mechanisms by which these substances exert their hypolipidemic activity in vivo.

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Current application and modification strategy of marine polysaccharides in tissue regeneration: A review

Cited by 18 publications

References 529 publications

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Metabolic bone disorders and the promise of marine osteoactive compounds

Advances in Research on Marine-Derived Lipid-Lowering Active Substances and Their Molecular Mechanisms

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