Current applications and perspectives of genomic selection in Bos indicus (Nellore) cattle

Júnior, Gerardo Alves Fernandes; Peripolli, Elisa; Schmidt, Patrícia Iana; Campos, Gabriel Soares; Mota, Lúcio Flávio Macêdo; Mercadante, Maria Eugênia Zerlotti; Baldi, Fernando; Carvalheiro, Roberto; Albuquerque, Lúcia Galvão de

doi:10.1016/j.livsci.2022.105001

Cited by 11 publications

(1 citation statement)

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“…Nellore cattle ( Bos taurus indicus ) is the main beef cattle breed raised in Brazil, i.e., one of the largest beef producers and exporters in the world ( United States Department of Agriculture, 2023 ). Nellore animals are well adapted to harsh climatic conditions and Brazilian herds have experienced major genetic progress for performance traits over the past decades ( Fernandes Junior. et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Detection and characterization of copy number variation in three differentially-selected Nellore cattle populations

Benfica,

Brito,

do Bem

et al. 2024

Front. Genet.

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Introduction: Nellore cattle (Bos taurus indicus) is the main beef cattle breed raised in Brazil. This breed is well adapted to tropical conditions and, more recently, has experienced intensive genetic selection for multiple performance traits. Over the past 43 years, an experimental breeding program has been developed in the Institute of Animal Science (IZ, Sertaozinho, SP, Brazil), which resulted in three differentially-selected lines known as Nellore Control (NeC), Nellore Selection (NeS), and Nellore Traditional (NeT). The primary goal of this selection experiment was to determine the response to selection for yearling weight (YW) and residual feed intake (RFI) on Nellore cattle. The main objectives of this study were to: 1) identify copy number variation (CNVs) in Nellore cattle from three selection lines; 2) identify and characterize CNV regions (CNVR) on these three lines; and 3) perform functional enrichment analyses of the CNVR identified.Results: A total of 14,914 unique CNVs and 1,884 CNVRs were identified when considering all lines as a single population. The CNVRs were non-uniformly distributed across the chromosomes of the three selection lines included in the study. The NeT line had the highest number of CNVRs (n = 1,493), followed by the NeS (n = 823) and NeC (n = 482) lines. The CNVRs covered 23,449,890 bp (0.94%), 40,175,556 bp (1.61%), and 63,212,273 bp (2.54%) of the genome of the NeC, NeS, and NeT lines, respectively. Two CNVRs were commonly identified between the three lines, and six, two, and four exclusive regions were identified for NeC, NeS, and NeT, respectively. All the exclusive regions overlap with important genes, such as SMARCD3, SLC15A1, and MAPK1. Key biological processes associated with the candidate genes were identified, including pathways related to growth and metabolism.Conclusion: This study revealed large variability in CNVs and CNVRs across three Nellore lines differentially selected for YW and RFI. Gene annotation and gene ontology analyses of the exclusive CNVRs to each line revealed specific genes and biological processes involved in the expression of growth and feed efficiency traits. These findings contribute to the understanding of the genetic mechanisms underlying the phenotypic differences among the three Nellore selection lines.

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Section: Introductionmentioning

confidence: 99%