Current applications of Colloidal Liquid Aphrons: Predispersed solvent extraction, enzyme immobilization and drug delivery

Ward, Keeran; Taylor, Anasha; Mohammed, Akeem; Stuckey, David C.

doi:10.1016/j.cis.2019.102079

Cited by 10 publications

(3 citation statements)

References 51 publications

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“…Polyaphrons (also called colloidal liquid aphrons and biliquid foams) have, over time, been used or proposed for diverse industrial applications (for example, in purification, extraction, drilling and waste water treatment [ 16 , 17 ]) due to their high stability, specific physicochemical properties and ability to flow, but are relatively unknown in medical applications [ 17 ].…”

Section: Physical and Chemical Characteristics Of Polyaphron Dispersi...mentioning

confidence: 99%

“…Sebba originally proposed that the shell structure is an organized surfactant bilayer and a so-called soapy shell [ 19 ]. However, based on subsequent studies, consensus has evolved that Sebba’s initial model is probably too simplistic and that a multi-molecular or multi-layer structure is an integrated part of the PAD droplet shell [ 17 , 20 ]. This multi-molecular/layer organization should not be interpreted as uninterrupted static consecutive layers, but rather envisioned as a dynamic nanoscale three-dimensional bicontinuous structure involving surfactants and auxiliary molecules such as bound water and oil (Fig.…”

Section: Physical and Chemical Characteristics Of Polyaphron Dispersi...mentioning

confidence: 99%

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Polyaphron Dispersion Technology, A Novel Topical Formulation and Delivery System Combining Drug Penetration, Local Tolerability and Convenience of Application

Præstegaard

Steele²,

Crutchley

2022

Dermatol Ther (Heidelb)

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Topical formulation and delivery technologies for pharmaceutical application should simultaneously address efficacy, safety and convenience of therapy. This has historically proven to be challenging, since formulation features that drive efficacy often have undesirable consequences for safety and convenience and vice versa. Polyaphron dispersion (PAD) technology is a novel topical formulation and drug delivery system developed with the purpose of preserving these key attributes. PAD formulations are typically oil-in-water dispersions consisting of oil droplets encapsulated in a multi-molecular shell structure. This shell structure protects potentially unstable active molecules solubilized in the oil from hydrolytic degradation. Example data are presented of enhanced drug penetration from PAD formulations, including dermal delivery of calcipotriene, betamethasone dipropionate and tacrolimus as well as ocular delivery of ciclosporin A. Local tolerability is an important safety parameter for topical formulations, where high levels of surfactants can cause skin irritation. In this regard, a key benefit of PAD formulations is the inherent reduced requirement for surfactants to generate stable formulations compared to conventional emulsion systems. Patients with chronic diseases with topical manifestations such as psoriasis or atopic dermatitis have been reported to miss up to 70% of planned topical applications, mainly due to a lack of satisfaction with their therapy. Patients generally prefer light, moisturizing, non-greasy and quickly absorbed vehicles that are simple to use on all body parts. PAD formulations can generally be designed to meet these criteria. In conclusion, PAD technology provides high flexibility in topical drug design and can be applied to several body locations without compromising efficacy, safety or convenience of therapy. Clinical Trial Register : Clinicaltrials.gov: NCT03802344.

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Section: Physical and Chemical Characteristics Of Polyaphron Dispersi...mentioning

confidence: 99%

Section: Physical and Chemical Characteristics Of Polyaphron Dispersi...mentioning

confidence: 99%

Polyaphron Dispersion Technology, A Novel Topical Formulation and Delivery System Combining Drug Penetration, Local Tolerability and Convenience of Application

Præstegaard

Steele²,

Crutchley

2022

Dermatol Ther (Heidelb)

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show abstract

“…Sphingosomes, 112–115 transferosomes, 116–122 liposomes, 123–129 emulsomes, 130–135 and virosomes are lipoidal carriers, 136–144 while aquasomes, 145–153 niosomes, 154–162 and bilosomes 163–178 are non-lipoidal. Nanoparticles, 179–185 polymeric micelles, 186–197 colloidal transfer systems 198–205 and other pharmacological carriers including biological macromolecules are suitable for targeted drug administration.…”

Section: Introductionmentioning

confidence: 99%