2018
DOI: 10.4048/jbc.2018.21.e47
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Current Approaches in Development of Immunotherapeutic Vaccines for Breast Cancer

Abstract: Cancer is the leading cause of death worldwide. In developed as well as developing countries, breast cancer is the most common cancer found among women. Currently, treatment of breast cancer consists mainly of surgery, chemotherapy, hormone therapy, and radiotherapy. In recent years, because of increased understanding of the therapeutic potential of immunotherapy in cancer prevention, cancer vaccines have gained importance. Here, we review various immunotherapeutic breast cancer vaccines including peptide-base… Show more

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Cited by 20 publications
(16 citation statements)
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“…Cancer vaccines are immunotherapies used to prevent the development of cancer in high-risk populations (prophylactic vaccines) or treat existing cancer (therapeutic vaccines) 1 Therapeutic cancer vaccines generally work by enhancing the ability of the immune system to recognize tumor antigens, thereby activating antigen-specific cytotoxic effects that target and kill cancer cells. 2 Various bacterial species have been shown to enter and replicate within tumors, exhibiting “tumor-finding” behavior. 3 A study found that attenuated S. typhimurium after intravenous injection would accumulate specifically in a tumor and then trigger tumor thrombosis due to the release of TNF-α (tumor necrosis factor-alpha, TNF-α) and proinflammatory factors.…”
Section: Introductionmentioning
confidence: 99%
“…Cancer vaccines are immunotherapies used to prevent the development of cancer in high-risk populations (prophylactic vaccines) or treat existing cancer (therapeutic vaccines) 1 Therapeutic cancer vaccines generally work by enhancing the ability of the immune system to recognize tumor antigens, thereby activating antigen-specific cytotoxic effects that target and kill cancer cells. 2 Various bacterial species have been shown to enter and replicate within tumors, exhibiting “tumor-finding” behavior. 3 A study found that attenuated S. typhimurium after intravenous injection would accumulate specifically in a tumor and then trigger tumor thrombosis due to the release of TNF-α (tumor necrosis factor-alpha, TNF-α) and proinflammatory factors.…”
Section: Introductionmentioning
confidence: 99%
“…Breast cancer (BC), one of the most common cancers among women, accounts for about 25% of all kinds of cancers [ 1 , 2 ]. Mammary gland is not an important organ to maintain human life activities and BC in situ is not fatal.…”
Section: Introductionmentioning
confidence: 99%
“…Whole tumor cell vaccines have been tested in clinical and preclinical studies (Keenan and Jaffee, 2012;Srivatsan et al, 2014;Pan et al, 2018;Wang et al, 2018), and have several advantages in cancer immunotherapy (Wang et al, 2018). Whole tumor cell vaccines offer tumor antigens and tumor associated antigen to elicit tumor-specific immunity (Chiang et al, 2015;Allahverdiyev et al, 2018). Whole tumor cell vaccines facilitate a high-efficiency antitumor response (Si et al, 2017).…”
Section: Introductionmentioning
confidence: 99%