Current approaches to neurosurgical treatment for drug-resistant focal epilepsy in adults

Narodova, Ekaterina A.; Narodov, A. A.; Shnayder, N. А.; Дмитренко, Д. В.; Strotskaya, Irina G.

doi:10.14412/2074-2711-2018-1s-81-88

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…TLE is characterized by a variable onset [3] and different epileptic seizures [4]. Furthermore, this form of epilepsy is often resistant to pharmacotherapy [5][6][7]. The etiology of TLE is variable and includes the influence of external environmental and genetic factors: genetic [8] and epigenetic mechanisms [9]; family forms TLE [10,11]; chronic neuro-inflammation [12]; neuronal death/apoptosis [13]; disorders of neurogenesis [9] (hippocampal sclerosis [14], focal cortical dysplasia [15,16], polymicrogyria, and nodal heterotopy [17]).…”

Section: Introductionmentioning

confidence: 99%

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review

Yakovleva

Дмитренко

Panina

et al. 2022

IJMS

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Temporal lobe epilepsy (TLE) is one of the most common forms of focal epilepsy in children and adults. TLE is characterized by variable onset and seizures. Moreover, this form of epilepsy is often resistant to pharmacotherapy. The search for new mechanisms for the development of TLE may provide us with a key to the development of new diagnostic methods and a personalized approach to the treatment. In recent years, the role of non-coding ribonucleic acids (RNA) has been actively studied, among which microRNA (miR) is of the greatest interest. (1) Background: The purpose of the systematic review is to analyze the studies carried out on the role of miRs in the development of mesial TLE (mTLE) and update the existing knowledge about the biomarkers of this disease. (2) Methods: The search for publications was carried out in the databases PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, Cochrane. The search was carried out using keywords and combinations. We analyzed publications for 2016‒2021, including original studies in an animal model of TLE and with the participation of patients with TLE, thematic and systemic reviews, and Cochrane reviews. (3) Results: this thematic review showed that miR‒155, miR‒153, miR‒361‒5p, miR‒4668‒5p, miR‒8071, miR‒197‒5p, miR‒145, miR‒181, miR‒199a, miR‒1183, miR‒129‒2‒3p, miR‒143‒3p (upregulation), miR–134, miR‒0067835, and miR‒153 (downregulation) can be considered as biomarkers of mTLE. However, the roles of miR‒146a, miR‒142, miR‒106b, and miR‒223 are questionable and need further study. (4) Conclusion: In the future, it will be possible to consider previously studied miRs, which have high specificity and sensitivity in mTLE, as prognostic biomarkers (predictors) of the risk of developing this disease in patients with potentially epileptogenic structural damage to the mesial regions of the temporal lobe of the brain (congenital disorders of the neuronal migration and neurogenesis, brain injury, neuro-inflammation, tumor, impaired blood supply, neurodegeneration, etc.).

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Section: Introductionmentioning

confidence: 99%

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review

Yakovleva

Дмитренко

Panina

et al. 2022

IJMS

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Problems of diagnosing focal cortical dysplasia

Yakovleva

Kantemirova

Дмитренко

2021

Èpilepsiâ paroksizmalʹnye sostoâ.

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Focal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures. Routine electroencephalography (EEG) data registered diffuse epileptiform activity that allowed to diagnose genetic eneralized epilepsy and pharmacoresistant course of seizures.After performing magnetic resonance imaging using the epileptological program and video-EEG-monitoring, the diagnosis was revised: structural focal epilepsy with seizures with focal onset with oroalimentary, gesture automatisms in the right hand, bilateral tonic-clonic, uncompensated by levetiracetam monotherapy (1500 mg/day). Background disease: congenital malformation of the brain: FCD in the basal parts of the left temporal lobe. Lacosamide was added to the therapy in the drug dose 300 mg/day, and the frequency of epileptic seizures decreased. Differential diagnosis between genetic generalized epilepsy and structural epilepsy with FCD usually poses no obstacles. However, in some cases, structural epilepsy occurs under the “mask” of generalized epilepsy. Hence, this clinical case demonstrates the importance of diagnostic measures in the differential diagnostics of various forms of epilepsy to determine further tactics of patient management.

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The experience of applying vagus nerve stimulation in treatment of pharmacoresistant epilepsy

Shatokhin,

Karpov,

Kushnareva

et al. 2023

Èpilepsiâ paroksizmalʹnye sostoâ.

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The article presents a clinical case of adult patient with pharmacoresistant epilepsy lacking focal cerebral morphological changes, who was surgically implanted with a vagus nerve stimulation (VNS) system. The results of 6 months-long treatment were analyzed. In addition, available publications were reviewed to evaluate effectiveness of the VNS system in different patient groups. Current clinical case was featured with significant positive dynamics revealed by regression of epileptic seizures and no recorded epileptiform activity based on electroencephalography during VNS stimulation. In the absence of morphological cerebral focal changes in adult patients, installation of the VNS system is an effective and safe method to control pharmacoresistant epilepsy.

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Current approaches to neurosurgical treatment for drug-resistant focal epilepsy in adults

Cited by 4 publications

References 41 publications

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review

Expression Profile of miRs in Mesial Temporal Lobe Epilepsy: Systematic Review

Problems of diagnosing focal cortical dysplasia

The experience of applying vagus nerve stimulation in treatment of pharmacoresistant epilepsy

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