Current aspects for the treatment of axial spondyloarthritis

Ku, Chiao-Hsin; Lee, Yung‐Heng; Wei, James Cheng‐Chung; Braun, Jürgen

doi:10.1111/1756-185x.14473

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…However, female patients may also have worse HRQoL measured by ASAS‐HI and AsQol 44,45 . Additionally, HLA‐B27 positivity is strongly associated with axSpA, 46 which may worsen clinical manifestations and promote earlier disease onset 47,48 . In our study, HLA‐B27‐positive patients had more serious functional impairments and were younger (Table 3 and Table S4).…”

Section: Discussionmentioning

confidence: 60%

“…44,45 Additionally, HLA-B27 positivity is strongly associated with axSpA, 46 which may worsen clinical manifestations and promote earlier disease onset. 47,48 In our study, HLA-B27-positive patients had more serious functional impairments and were younger (Table 3 and Table S4). Furthermore, hip involvement is also a common manifestation of axSpA, affecting 26.8% of patients (Table 3 and Table S5).…”

Section: It Is Well-established That Several Factors Can Indirectly A...mentioning

confidence: 62%

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Exploring physical function and physical activity in axial spondyloarthritis: Beyond clinical remission or low disease activity

Pei,

Zheng,

Zhang

et al. 2023

Int J of Rheum Dis

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ObjectivesTo investigate the crucial roles of physical function (PF) and physical activity (PA) in axial spondyloarthritis (axSpA) patients, as well as their correlation with disease activity (DA), and to explore the influence of general characteristics among them.MethodsWe enrolled axSpA patients from Xijing Hospital, spanning March 2022 to August 2022. Spearman rank correlation coefficients were used to assess correlations between PA (measured by the Global Physical Activity Questionnaire [GPAQ]), PF (measured by the Assessment of Spondyloarthritis international Society Health Index [ASAS‐HI], the Short Form 36‐Item Health Survey [SF‐36], and the Bath Ankylosing Spondylitis Functional Index [BASFI]), DA, and their influencing factors. A Mann–Whitney U‐test and Kruskal–Wallis H‐test were used to compare variables between different patients grouped by sex, human leukocyte antigen B27 (HLA‐B27), hip involvement, and intensity of PA and DA.ResultsThree hundred fifty‐five axSpA patients were included. We observed a moderate to strong correlation between DA and PF in axSpA patients. PA was weakly correlated with DA or PF. DA varied significantly at different PA levels, and patients with low PA levels had poorer PF. Active patients had worse PF, less transport‐related PA, and a higher rate of hip involvement with a worse Harris Hip Score (HHS).ConclusionsWe identified a close relationship between DA, PF, and PA in axSpA patients. Further, gender, HLA‐B27, and hip involvement affected the clinical manifestation of axSpA patients. These findings demonstrate that clinical remission of axSpA patients requires a comprehensive assessment rather than a single remission of DA.

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Section: Discussionmentioning

confidence: 60%

Section: It Is Well-established That Several Factors Can Indirectly A...mentioning

confidence: 62%

Exploring physical function and physical activity in axial spondyloarthritis: Beyond clinical remission or low disease activity

Pei,

Zheng,

Zhang

et al. 2023

Int J of Rheum Dis

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“…Consensus from Spanish Rheumatology Society also stated the same timing for biologics‐tapering initiation after therapeutic goal was achieved and maintained 3 . From our perspective, 4 at least 6–12 months of remission and no radiographical progression must be obtained before decrease in biological dosing or intervals 4 …”

mentioning

confidence: 89%

“…3 From our perspective, 4 at least 6-12 months of remission and no radiographical progression must be obtained before decrease in biological dosing or intervals. 4 Timing of tapering biologics should be personalized and flexible. For instance, individuals with unfavorable factors, such as high disease activity indexes, poor patient-reported outcomes (PROs), and rapid progression in imaging, remission should be maintained for longer time.…”

Section: Personalized Tapering Of Tumor Necrosis Factor Inhibitor In ...mentioning

confidence: 99%

Personalized tapering of tumor necrosis factor inhibitor in axial spondyloarthritis

Huang,

Lee,

Leong

et al. 2023

Int J of Rheum Dis

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“…Recently, researchers identified the symptoms of patients with AS in form of the symptom cluster, including the gastrointestinal‐cardiac symptom cluster, the fatigue‐sleep disturbance symptom cluster, the headache‐chest pain symptom cluster and the mouth‐eye symptom cluster 1 . Although multiple treatments including non‐pharmacological therapies and pharmacological therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) and anti‐tumor necrosis factor (anti‐TNF) therapy can be chosen to treat AS patients, 2 people still encounter great challenges in the treatment. Therefore, to help AS patients, it is important to deeply understand the pathogenesis of this disease and develop more effective therapies.…”

Section: Introductionmentioning

confidence: 99%

The study of the effect of HLA‐B27 on THP‐1 monocytic cells survival and its mechanism

Gui

2023

Int J of Rheum Dis

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Objective Previous studies have shown that human leukocyte antigen (HLA)‐B27 induces the accumulation of unfolded proteins in the endoplasmic reticulum (ER) to cause ER stress, resulting in the unfold protein response (UPR), apoptosis and autophagy. However, it is still unknown whether it affects the survival of monocytes. In this study, we attempted to examine the effect of HLA‐B27 gene knockout on the proliferation and apoptosis of THP‐1 monocytic cell line and its potential mechanism. Methods HLA‐B27 gene knockout THP‐1 cell line was constructed by lentivirus infection, and knockout efficiency was detected by immunofluorescence, quantitative reverse transcription ‐ polymerase chain reaction (qRT‐PCR) and western blot. Cell Counting Kit‐8 (CCK‐8) method and Annexin‐V/PI double staining were used to detect the proliferation and apoptosis of the constructed THP‐1 cell line, respectively. qRT‐PCR was used to detect the effect of HLA‐B27 inhibition on the expressions of ER molecular chaperone binding immunoglobulin protein (BiP) and genes about the UPR pathway. The proliferation rate of human BiP protein‐stimulated THP‐1 cells was detected by CCK‐8 method. Results HLA‐B27 gene knockout THP‐1 cells were successfully constructed by lentivirus infection. Knockout of HLA‐B27 effectively promoted the proliferation of THP‐1 cells and inhibited the apoptosis induced by cisplatin. qRT‐PCR showed that BiP was synchronously increased, while activation of UPR pathway was inhibited. Stimulation with human BiP promoted the proliferation of THP‐1 cells in a concentration‐dependent manner. Conclusions HLA‐B27 inhibition can promote the proliferation and inhibit the apoptosis of THP‐1 cells. The inhibition function may be achieved through promotion of BiP and inhibition of UPR pathway activation.

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Current aspects for the treatment of axial spondyloarthritis

Cited by 5 publications

References 30 publications

Exploring physical function and physical activity in axial spondyloarthritis: Beyond clinical remission or low disease activity

Exploring physical function and physical activity in axial spondyloarthritis: Beyond clinical remission or low disease activity

Personalized tapering of tumor necrosis factor inhibitor in axial spondyloarthritis

The study of the effect of HLA‐B27 on THP‐1 monocytic cells survival and its mechanism

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