Current biomechanical theories on the etiopathogenesis of idiopathic scoliosis

Pizones, Javier; Chang, Dong-Gune; Suk, Se-Il; Izquierdo, Enrique

doi:10.1007/s43390-023-00787-7

Cited by 2 publications

(4 citation statements)

References 62 publications

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“…One of the suggested hypotheses on AIS etiology is a melatonin alteration or an abnormal bone mineralization in combination with increased bony growth. 3 However, it seems clear that a genetic predisposition must play a role in AIS etiopathogenesis. Anderson et al described a 1.05% prevalence in monozygotic twins, indicating evidence of a genetic predisposition for AIS.…”

Section: Discussionmentioning

confidence: 99%

“…8 Currently, the complex interplay of genetic, internal, and environmental factors has become an evident etiological theory with wide phenotypic variations. 3 There have been advancements in the understanding of etiology for AIS, but there is little information on the inter-relationship of siblings in AIS. Furthermore, we are not aware of any cases where both siblings have undergone deformity correction because of severe deformation of scoliosis.…”

Section: Discussionmentioning

confidence: 99%

“…Our rare case supports the underlying basis of genetic heterogeneity as a complex polygenic model in both siblings. 3,5 Meanwhile, in the case of nonidiopathic scoliosis, there are several radiological features including a long collapsing C-shape scoliotic curve, marked pelvic obliquity, and elevation of the iliac crest on the concave side of the curvature. 1 By considering the radiological features of nonidiopathic scoliosis, our study presented more like idiopathic scoliosis.…”

Section: Figurementioning

confidence: 99%

“…1,2 Especially, the heritability of AIS has been attempted to be explained through a complex polygenic model that suggested considerable genetic heterogeneity. 1,3 The pedigree analyses have supported the concept of polygenic inheritance indicating that men with AIS are more likely to have siblings and children with scoliosis compared with women. 4,5 The AIS in siblings reflects this genetic hypothesis; however, few studies have been published on this topic.…”

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confidence: 93%

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Adolescent Idiopathic Scoliosis in Siblings Treated by Surgical Deformity Correction

Kim,

Pizones,

Chang

2024

JAAOS Glob Res Rev

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Adolescent idiopathic scoliosis (AIS) in siblings reflects genetic hypothesis; however, few studies have been published. Furthermore, to the best of our knowledge, there have been no reports in the literature of both siblings with AIS who underwent deformity corrections. A 15-year-old adolescent girl visited our clinic with back pain after recognition of the incidental findings of a scoliotic curve in the spine. Whole spine radiographs detected Lenke classification type 3CN. The patient underwent deformity correction with posterior instrumented fusion from T4 to L3 with thoracoplasty of the right 7th to 10th rib. Four years later, her 16-year-old younger brother also visited our clinic with back pain after recognition of the incidental findings of a scoliotic curve in the spine. Whole spine radiographs detected Lenke classification type 2AN. The patient underwent deformity correction with posterior instrumented fusion from T5 to L2 with thoracoplasty of the right 8th to 10th rib. In conclusion, we report on two siblings with AIS who underwent surgical treatment for different types of curves. They showed favorable outcomes after performing deformity correction with posterior instrumented fusion. Our rare case supports the underlying basis of genetic heterogeneity as a complex polygenic model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

mentioning

confidence: 93%

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Adolescent Idiopathic Scoliosis in Siblings Treated by Surgical Deformity Correction

Kim,

Pizones,

Chang

2024

JAAOS Glob Res Rev

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National and regional trends in the prevalence of adolescent idiopathic scoliosis in South Korean military draftees

Kim,

et al. 2024

BMJ Mil Health

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IntroductionRecent epidemiological and aetiological data on adolescent idiopathic scoliosis (AIS) among military draftees are scarce in nationwide and population-based databases. This retrospective, nationwide and population-based study aims to assess national and regional trends in the prevalence of AIS among military draftees in South Korea from 2013 to 2022.MethodsA total of 3 166 669 Korean males were screened at regional Military Manpower Administration (MMA) offices between 2013 and 2022. Based on routine chest radiographs, individuals with Cobb’s angle of ≥10° were screened and diagnosed with AIS using whole spine radiographs after excluding surgically treated AIS patients. Data from the MMA were retrospectively collected and the annual prevalence of the total and neglected AIS cases, along with 95% CIs, was assessed. Spearman correlation analysis was performed to evaluate the correlation between the prevalence of AIS and several aetiological factors.ResultsThe prevalence rate of AIS in the male adolescent population gradually increased from 2013 (0.44%, 95% CI 0.42% to 0.46%) to 2022 (1.33%, 95% CI 1.28% to 1.37%). The AIS rate increased overall in both capital/metropolitan areas and provinces but showed a fluctuating pattern in the capital/metropolitan area. The prevalence rate of neglected AIS showed a very slight increased trend during the same period (mean 0.05%, 95% CI 0.04% to 0.06%) and exhibited a similar pattern in both capital/metropolitan areas and provinces. Using correlation analysis with aetiological factors, the prevalence rate of AIS correlated with overweight or obesity rate (r=0.90, p<0.001) and growth hormone use (r=0.83, p<0.001).ConclusionsThe prevalence of AIS in the male population has increased, with a similar trend observed between capital/metropolitan areas and provinces in South Korea. Our correlation results support both the multifactorial cascade concepts for altered body composition effects and biomechanical progression based on the Hueter-Volkmann effect as the pathomechanisms of AIS.

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Current biomechanical theories on the etiopathogenesis of idiopathic scoliosis

Cited by 2 publications

References 62 publications

Adolescent Idiopathic Scoliosis in Siblings Treated by Surgical Deformity Correction

Adolescent Idiopathic Scoliosis in Siblings Treated by Surgical Deformity Correction

National and regional trends in the prevalence of adolescent idiopathic scoliosis in South Korean military draftees

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