Current challenges of diabetes and metabolic disorders in China

Ji, Linong

doi:10.1111/dom.15048

Cited by 8 publications

(1 citation statement)

References 10 publications

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“…The MetS is characterized by a clustering of cardiovascular risk factors, including central obesity, elevated blood pressure, dyslipidemia (high triglycerides), low high-density lipoprotein cholesterol (HDL-C), and fasting hyperglycemia ( 5 ). MetS is on the rise globally and is clinically important due to its association with cardiovascular disease, T2DM, and cancer ( 6 ). Although the pathogenesis of MetS is not well defined, Mg may play a role in the development of MetS, insulin resistance, and chronic low-grade inflammation due to central obesity, which are the most widely accepted underlying reasons ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Association and dose–response relationship of plasma magnesium with metabolic syndrome in Chinese adults older than 45 years

Yang,

Cao,

Zhang

et al. 2024

Front. Nutr.

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PurposeMagnesium (Mg) is an essential nutrient for the maintenance of vital physiological functions. Magnesium deficiency is associated with diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS); however, conclusions have been inconsistent, and there is a particular lack of evidence regarding this association in Chinese population older than 45 years. This study aimed to assess the association between plasma magnesium and the risk of MetS and its components, the dose–response relationship, and the threshold effect relationship in a Chinese population involving older than 45 years.MethodsA total of 2,101 individuals were randomly selected from the China Nutrition and Health Surveillance (CNHS) (2015–2017) by considering monitoring points. We used the joint statement of the International Diabetes Federation (IDF) in 2009 to define participants with MetS. The plasma magnesium was tested by inductively coupled plasma mass spectrometry (ICP-MS). The logistic regression and restricted cubic spline (RCS) models were used to analyze the association and dose–response relationship between plasma Mg and MetS and its components.ResultsCompared with the lowest quintile (Q1) for plasma Mg, the odds ratios (ORs) and 95% confidence intervals (95% CI) for MetS, impaired fasting glucose (IFG), hypertension, and triglyceride (TG) elevation at the highest quintile (Q5) were 0.419 (0.301, 0.583), 0.303 (0.221, 0.415), 0.446 (0.322, 0.618), and 0.526 (0.384, 0.720), respectively, with all p < 0.05. However, in the components of decreased high-density lipoprotein cholesterol (HDL-C) and central obesity, no trend toward lowering with higher plasma magnesium was observed (p = 0.717, p = 0.865). These associations were not altered by further adjustment for potential confounding variables, including age, gender, education, nationality, area, residence, body mass index (BMI), and heart rate. The RCS analysis showed that, when plasma magnesium was lower than 0.85 mmol/L, the curve was leveled off, and then, the curve showed a decreasing trend with the increase in plasma magnesium.ConclusionTherefore, plasma Mg was negatively associated with MetS and its components (including IFG, hypertension, and elevated TG) in people older than 45 years. In addition, plasma Mg greater than or equal to 0.85 mmol/L, which is higher than the commonly used threshold of 0.75 mmol/L, may be protective against MetS and its components (including elevated FPG, elevated blood pressure, and elevated TG). More prospective studies, such as randomized controlled trials, are necessary to confirm the effective impact of Mg on MetS and its components. Plasma Mg levels in the MetS population older than 45 years require attention.

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Section: Introductionmentioning

confidence: 99%

Association and dose–response relationship of plasma magnesium with metabolic syndrome in Chinese adults older than 45 years

Yang,

Cao,

Zhang

et al. 2024

Front. Nutr.

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Inquiry lipaseoring the mechanism of pancreatic lipase inhibition by isovitexin based on multispectral method and enzyme inhibition assay

Yu,

Xing,

Jia

et al. 2024

Luminescence

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Isovitexin is a main natural flavonoid component in various plants. Currently, the inhibitory effect of isovitexin on pancreatic lipase (PL) and its mechanism have not been elucidated yet. In the present study, we investigated the inhibitory effect of isovitexin on PL, as well as its interaction mechanism, using enzyme inhibition methods, spectroscopic analysis, and molecular simulations. Results showed that isovitexin possessed significant PL inhibitory activity, with IC50 values of 0.26 ± 0.02 mM. The interaction between isovitexin and PL was dominated by static quenching, and mainly through hydrogen bonding and hydrophobic interaction forces. Analysis of fluorescence spectroscopy confirmed that isovitexin binding altered the conformation of the PL. Circular dichroism (CD) spectrum indicated that isovitexin altered the secondary structure of PL by decreasing the α‐helix content and increasing the β‐fold content. Molecular simulations further characterize the conformational changes produced by the interaction between isovitexin with PL. The performed study may provide a new insight into the inhibitory mechanism of isovitexin as a novel PL inhibitor.

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Alleviation of hepatic insulin resistance and steatosis with NMN via improving endoplasmic reticulum–Mitochondria miscommunication in the liver of HFD mice

Li,

Tian,

et al. 2024

Biomedicine & Pharmacotherapy

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Current challenges of diabetes and metabolic disorders in China

Abstract: The China Diabetes Society was established 30 years ago, when diabetes started to emerge as the most common and lifethreatening metabolic disease in China, and its prevalence has

Cited by 8 publications

References 10 publications

Association and dose–response relationship of plasma magnesium with metabolic syndrome in Chinese adults older than 45 years

Association and dose–response relationship of plasma magnesium with metabolic syndrome in Chinese adults older than 45 years

Inquiry lipaseoring the mechanism of pancreatic lipase inhibition by isovitexin based on multispectral method and enzyme inhibition assay

Alleviation of hepatic insulin resistance and steatosis with NMN via improving endoplasmic reticulum–Mitochondria miscommunication in the liver of HFD mice

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