Current clinical application of sclera and amniotic membrane for ocular tissue bio-replacement

Sabater-Cruz, Noelia; Figueras‐Roca, Marc; Ventosa, A. González; Padró-Pitarch, Lydia; Tort, Jaume; Casaroli‐Marano, Ricardo P.

doi:10.1007/s10561-020-09848-x

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…Therefore, in the absence of a response to pharmacological treatment, AMT became the first surgical option for NHCU in the hospitals enrolled in our study. This idea was also supported by a recently published article that revealed that corneal ulcers are the first indications for AMTs [ 60 ].…”

Section: Discussionmentioning

confidence: 77%

Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study

Lacorzana

Campos

Brocal-Sánchez

et al. 2021

JCM

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Background: To evaluate new indicators in the efficacy of amniotic membrane transplantation (AMT) for non-healing corneal ulcers (NHCUs). Methods: Retrospective, multicenter study. In total, 223 AMTs for NHCU in 191 patients were assessed. The main outcomes studied were the success rate of AMT (complete re-epithelization), postoperative visual acuity (VA) gain, and number of AM layers transplanted. Results: The overall AMT success rate was 74.4%. In 92% of our patients VA stability or improvement. Postoperative VA was significantly higher than preoperative VA in the entire cohort (p < 0.001) and in all etiological groups of ulcers (post-bacterial, p ≤ 0.001; post-herpetic, p ≤ 0.0038; neurotrophic ulcers, p ≤ 0.014; non-rheumatic peripheral, p ≤ 0.001; and ulcers secondary to lagophthalmos and eyelid malposition or trauma, p ≤ 0.004). Most participants (56.5%) presented a preoperative VA equal to or less than counting fingers (≤0.01). Of these, 13.5% reached a postoperative VA equal to or better than legal blindness (≥0.05) after AMT. A higher success rate was observed in the monolayer than in the multilayer AMT (79.5% and 64.9%, respectively; p = 0.018). No statistically significant values were found between the number of layers transplanted and VA gain (p = 0.509). Conclusion: AMT is not only beneficial in achieving complete re-epithelialization in NHCUs but also in improving postoperative VA; these improvements are independent of etiologies of ulcers. Furthermore, the use of monolayer AMT seems to be a more appropriate option than multilayer AMT for NHCU since the multilayer AMT did not present better outcomes (success rate and VA gain) compared to monolayer AMT in the different types of ulcers studied.

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Section: Discussionmentioning

confidence: 77%

Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study

Lacorzana

Campos

Brocal-Sánchez

et al. 2021

JCM

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Section: Allogeneic Sclera Graftmentioning

confidence: 99%

“…Scleral segments are cost-efficient and associated with a low risk of pathogen transmission in addition to their wide availability, strength, flexibility, and ease of storage (63). Sabater-Cruz et al (63) reviewed 874 scleral patches eye indications in a Spanish region over 6 years from 2013 to 2018. The scleral patch's most frequent indication over the 6 years was glaucoma surgery in 77.5%, eyelid reconstruction in 5.2%, and corneal or scleral ulcer in 5%.…”

Section: Allogeneic Sclera Graftmentioning

confidence: 99%

Posterior lamella substitutes in full-thickness eyelid reconstruction: a narrative review

Guo¹,

Gao²,

Ma³

et al. 2023

Front Oral Maxillofac Med

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Background and Objective: Severe full-thickness eyelid defects seriously endanger the health and beauty of the ocular surface. It is the most challenging field of oculoplastic and reconstructive surgery to reconstruct eyelid's natural appearance and function, in which the posterior eyelid lamella plays an essential role. Without enough substitute support in eyelids suffered sizeable posterior lamella defects, various complications may occur, e.g., entropion, ectropion, incomplete eyelid closure, corneal irritation, keratitis, corneal ulcers, and even vision loss, leading to failure of eyelid reconstruction. This manuscript aimed to summarize recent advances in posterior eyelid lamella substitutes and summarize the types, advantages, and disadvantages of the present posterior lamella substitutes in full-thickness eyelid reconstruction.Methods: A literature search was conducted in the PubMed database to identify relevant publications using the search algorithm "eyelid reconstruction". The full-text publication reports about posterior substitutes from January 2016 to April 2021 in English were selected and reviewed. We also screened relevant research missed in this search algorithm from the reference lists of specific full-text papers.

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“…Studies have demonstrated that the amniotic membrane can support epithelialization by offering a basement membrane and an avascular stromal matrix similar to the native conjunctiva. Furthermore, amniotic membrane possesses anti‐angiogenic, anti‐inflammatory, and anti‐scarring properties, making it the most widespread substitute for conjunctival replacement 75,76 . Clinically, decellularized amniotic membrane grafts are placed directly over the bare tarsus up to the eyelid margin 77,78 or applied in combination with other techniques for posterior lamellar reconstruction 79,80 .…”

Section: Acellular Approachesmentioning

confidence: 99%

Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration?

Yan

et al. 2023

Bioengineering & Transla Med

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Reconstruction of posterior lamellar eyelids remains challenging due to their delicate structure, highly specialized function, and cosmetic concerns. Current clinically available techniques for posterior lamellar reconstruction mainly focus on reconstructing the contour of the eyelids. However, the posterior lamella not only provides structural support for the eyelid but also offers a smooth mucosal surface to facilitate globe movement and secrete lipids to maintain ocular surface homeostasis. Bioengineered posterior lamellar substitutes developed via acellular or cellular approaches have shown promise as alternatives to current therapies and encouraging outcomes in animal studies and clinical conditions. Here, we provide a brief reference on the current application of autografts, biomaterials, and tissue‐engineered substitutes for posterior lamellar eyelid reconstruction. We also shed light on future challenges and directions for eyelid regeneration strategies and offer perspectives on transitioning replacement strategies to regeneration strategies for eyelid reconstruction in the future.

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Current clinical application of sclera and amniotic membrane for ocular tissue bio-replacement

Cited by 10 publications

References 25 publications

Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study

Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study

Posterior lamella substitutes in full-thickness eyelid reconstruction: a narrative review

Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration?

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