Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders

Tae, Woo Suk; Ham, Byung Joo; Pyun, Sung Bom; Kang, Sung Ho; Kim, Byung Jo

doi:10.3988/jcn.2018.14.2.129

Cited by 210 publications

(163 citation statements)

References 105 publications

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“…Additionally, the remote effects of WM lesions might make it possible to interrupt the subcortical motor circuits even if the frontal area was not involved. Further studies using diffusion tensor imaging, which can detect microstructural WM alterations (e.g., structural WM connectivity) early, would provide more answers with respect to the conclusions of this study.…”

Section: Discussionmentioning

confidence: 99%

White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease

Chung

Yoo

Lee

et al. 2020

Ann Clin Transl Neurol

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Objective To investigate whether the burden of white matter hyperintensities (WMHs) is associated with the risk of developing levodopa‐induced dyskinesia (LID) in Parkinson’s disease (PD). Methods According to the Clinical Research Center for Dementia of South Korea WMH visual rating scale, 336 patients with drug‐naïve early stage PD (follow‐up >3 years) were divided into two groups of PD with minimal WMHs (PD‐WMH–; n = 227) and moderate‐to‐severe WMHs (PD‐WMH+; n = 109). The Cox regression model was used to estimate the hazard ratio for the development of LID in the PD‐WMH + group compared with the PD‐WMH– group, while adjusting for age at PD onset, sex, striatal dopamine depletion, and PD medication dose. Additionally, we assessed the effects of WMH burden rated by the Scheltens scale and regional WMH distribution on the development of LID. Results Patients in the PD‐WMH + group were older and had more severe parkinsonian motor signs despite comparable striatal dopamine transporter availability than those in the PD‐WMH– group. Patients in the PD‐WMH + group had a higher risk of developing LID (hazard ratio, 2.66; P < 0.001) than those in the PD‐WMH– group after adjustment for other confounding factors. A greater WMH burden was associated with earlier occurrence of LID (hazard ratio, 1.04; P = 0.001), although the effects of WMHs on LID development did not exhibit region‐specific patterns. Interpretation The present study demonstrates that the burden of WMHs is associated with occurrence of LID in patients with PD, suggesting comorbid WMHs as a risk factor for LID.

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Section: Discussionmentioning

confidence: 99%

White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease

Chung

Yoo

Lee

et al. 2020

Ann Clin Transl Neurol

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“…Diffusion MRI is a widely used in-vivo imaging technique that measures the movement of water molecules in tissue, and recently, it has been used for clinical applications to diagnose neurodegenerative or psychiatric disorders 9 , 10 . Herein, we focused on an objective assessment of PPD using diffusion MRI.…”

Section: Introductionmentioning

confidence: 99%

Cerebral diffusion kurtosis imaging to assess the pathophysiology of postpartum depression

Sasaki

Ito

Fukumoto

et al. 2020

Sci Rep

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Postpartum depression (PPD), a main cause of maternal suicide, is an important issue in perinatal mental health. Recently, cerebral diffusion tensor imaging (DTI) studies have shown reduced fractional anisotropy (FA) in major depressive disorder (MDD) patients. There are, however, no reports using diffusion kurtosis imaging (DKI) for evaluation of PPD. This was a Japanese single-institutional prospective study from 2016 to 2019 to examine the pathophysiological changes in the brain of PPD patients using DKI. The DKI data from 3.0 T MRI of patients one month after delivery were analyzed; the patients were examined for PPD by a psychiatrist. The mean kurtosis (MK), FA and mean diffusivity (MD) were calculated from the DKI data and compared between PPD and non-PPD groups using tract-based spatial statistics analysis. Of the 75 patients analyzed, eight patients (10.7%) were diagnosed as having PPD. In the PPD group, FA values in the white matter and thalamus were significantly lower and MD values in the white matter and putamen were significantly higher. The area with significant differences in MD value was more extensive (40.8%) than the area with significant differences in FA value (6.5%). These findings may reflect pathophysiological differences of PPD compared with MDD.

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“…Additionally, we investigated whether changes in corpus callosum and gray matter in MDD had an anatomical relationship to each other. 35…”

Section: Introductionmentioning

confidence: 99%

Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls

Lee

Pyun

Choi

et al. 2020

Psychiatry Investig

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Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes.Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas.Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients.Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.

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Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders

Cited by 210 publications

References 105 publications

White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease

White matter hyperintensities and risk of levodopa‐induced dyskinesia in Parkinson’s disease

Cerebral diffusion kurtosis imaging to assess the pathophysiology of postpartum depression

Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls

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