Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair

Reissis, Dimitris; Tang, Quen; Cooper, Nina; Carasco, Clare Francesca; Gamie, Zakareya; Mantalaris, Athanasios; Tsiridis, Eleftherios

doi:10.1517/14712598.2016.1145651

Cited by 48 publications

(34 citation statements)

References 80 publications

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“…Administration of bone marrow-derived mesenchymal stromal cells (MSCs) in sites of cartilage injury is a valuable option to enhance the local processes of cartilage repair [7][8][9][10] due to the chondroreparative activities of these cells, [11][12][13] especially when provided as marrow concentrates in their natural, clinically relevant microenvironment using off-the-shelf, minimally invasive procedures. 14,15 Still, even with such convenient techniques, the long-term quality of repair tissue in the treated lesions remains unsatisfactory, with production of a poor fibrocartilaginous repair tissue (type-I collagen) unable to bear prolonged mechanical stress.…”

Section: Introductionmentioning

confidence: 99%

Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates

Venkatesan

Falentin‐Daudre

Leroux

et al. 2020

Tissue Engineering Part A

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Scaffold-guided gene transfer offers strong systems to develop non-invasive, convenient therapeutic options for the treatment of articular cartilage defects, especially when targeting bone marrow aspirates from patients containing chondroregenerative mesenchymal stromal cells in a native microenvironment. In the present study, we examined the feasibility of delivering reporter (RFP, lacZ) rAAV vectors over time to such samples via biocompatible, mechanically stable poly(caprolactone) (PCL) films grafted with poly(sodium styrene sulfonate) (pNaSS) for improved biological responses as clinically adapted tools for cartilage repair. Effective transgene expression (RFP, lacZ) was noted over time in human bone marrow aspirates using pNaSS-grafted films (up to 90% efficiency for at least 21 days) versus control conditions (ungrafted films, absence of vector coating on the films, free or no vector treatment), without displaying cytotoxic nor detrimental effects on the osteochondrogenic or hypertrophic potential of the samples. These findings demonstrate the potential of directly modifying therapeutic bone marrow from patients by controlled delivery of rAAV using biomaterial-guided procedures as a future, noninvasive strategy for clinical cartilage repair.

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Section: Introductionmentioning

confidence: 99%

Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates

Venkatesan

Falentin‐Daudre

Leroux

et al. 2020

Tissue Engineering Part A

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“…Fibrocartilaginous tissue cannot meet the needs of the joint exercise, which leads to the scope of the lesion expanding causing arthritis and leading to intractable pain and dysfunction. Therefore, the repair of articular cartilage injury has always been a difficult and hot spot in the field of orthopedic research [3–6]. …”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes

Shi

Liang

Guo

et al. 2017

Stem Cells International

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Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for multiple differentiations. However, its application has been largely limited by stem cell type, number, source, proliferation, and differentiation. We hypothesized that (1) adipose-derived stem cells are ideal seed cells for articular cartilage repair because of their accessibility and abundance and (2) the microenvironment of articular cartilage could induce adipose-derived stem cells (ADSCs) to differentiate into chondrocytes. In order to test our hypotheses, we isolated stem cells from rabbit adipose tissues and cocultured these ADSCs with rabbit articular cartilage chondrocytes. We found that when ADSCs were cocultured with chondrocytes, the proliferation of articular cartilage chondrocytes was promoted, the apoptosis of chondrocytes was inhibited, and the osteogenic and chondrogenic differentiation of ADSCs was enhanced. The study on the mechanism of this coculture system indicated that the role of this coculture system is similar to the function of TGF-β1 in the promotion of chondrocytes.

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“…Soler et al (35) developed a series of clinical trials in which autologous MSCs were injected into the body after in vitro expansion, resulting in regenerative cartilage in the injured area and therefore, concluded that the therapy is safe and viable. Existing studies have revealed that MSCs' cultured and expanded cartilage repair effect is equally effective as other therapies (36). Autologous chondrocytes and MSCs have their own advantages and disadvantages.…”

Section: In Vitro Culture Of Expanded Mscs For Repair Of Articular Camentioning

confidence: 99%

Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review

Abd-Elsayed

2018

Pain Phys

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Background: Knee osteoarthritis (KOA) is a very challenging condition to treat and can be resistant to medications, procedures, and even surgery. Surgery may not be an option for some patients due to obesity or comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA. Objective: This is a review article to evaluate the current evidence about regenerative medicine therapies in the treatment of KOA. Study Design: A review article. Setting: A review of literature. Methods: An online search of PubMed and Cochrane Library databases between January 2006 and December 2016 was performed to search related articles using the keywords of “treatment, stem cell, knee osteoarthritis,” limited to the English language. The articles were then screened to make sure only articles fitting our inclusion criteria were included. Results: Our search obtained a total of 268 articles, but only 18 articles met the inclusion criteria and were included in the current study. Limitations: There is still limited evidence in literature about the efficacy of regenerative medicine in treating KOA. More large clinical trials are needed to confirm the evidence. Conclusion: The present investigation demonstrates that regenerative medicine technologies provide good evidence in the treatment of osteoarthritis (OA) of the knee, but greater in-depth study to explore a more ideal way to overcome present difficulties, including standardization of sources of cells, is warranted. Key words: Knee osteoarthritis, stem cell, treatment, platelet rich plasma, amniotic fluid, articular cartilage defect

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Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair

Cited by 48 publications

References 80 publications

Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates

Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates

Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes

Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review

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