Current Clinical Features of New Patients With Takayasu Arteritis Observed From Cross-Country Research in Japan

Abstract

Background-The clinical features of newly diagnosed Japanese patients with Takayasu arteritis and its age or sex specificities are unknown. Methods and Results-We analyzed information from nationwide registration forms submitted by patients with Takayasu arteritis between April 2001 and March 2011 as part of a research program by the Japanese Ministry of Health, Labor and Welfare. Among the 7779 patients who submitted their forms, 1372 newly registered patients with Takayasu arteritis were enrolled; 83.8% were female. The median age at onset was 35 years, which was significantly higher in male patients (median, 43.5 years) than in female patients (median, 34 years; P<0.001). Local symptoms and findings were most commonly observed in the cervicobrachial area, with more complaints in the head or neck than in the upper limbs. Approximately 85% of the patients had vascular involvements in the aortic arch or its major branches; many young female patients had localized lesions. Although male patients had extensive aortic lesions or aneurysms with more complications, localized abdominal lesions were relatively more frequent in male patients with age at onset >40 years than in other agesex groups. Disease statuses were severe in patients who registered at ≥1 year after onset. Conclusions-The

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“…The incidence rate and average age of onset were higher in females than males, which is in keeping with the findings of previous studies [3, 9, 10]. However, the incidence in males and the average age of onset have risen in recent years [11]. Gender differences may be related to the role of estrogen or genetics [12].…”

Vasculitis Around the World: Epidemiologic Insights into Causality and a Need for Global Partnerships

“…Ophthalmic circulatory disturbances, ischemic heart disease, arrhythmia, congestive heart failure, and cerebral ischemia are commonly reported 1 . Similar clinical features of disease and distributions of arterial pathology are observed in patients with TA from the United States and Western Europe 4,5 . In contrast, middle-aged men in China or India can develop TA typically involving the abdominal aorta and renal arteries with corresponding symptoms of lower extremity claudication and renovascular hypertension 3,6 .…”

Continuous infusion of lipo-prostaglandin E1 for Takayasu’s arteritis with heart failure in an 11-month-old baby: a case report

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