Current concepts about treatment options of plantar fibromatosis: A systematic review of the literature

Experimental Analysis of Plantar Fascia Mechanical Properties in Subjects with Foot Pathologies

“…Another pathology affecting the PF is plantar fibromatosis, also called Ledderhose disease, which is a benign nodular formation usually in the medial part of the PF causing pain during gait [12,13]. Such disease is commonly treated by a partial or total aponeurotomy, although other options have recently been described [14,15]. In addition to diseases directly involving the PF, there are various systemic pathologies, primarily diabetes, that affect foot biomechanics in different ways.…”

Ledderhose Disease With Concomitant Presence of Dupuytren Contracture: A Case Report and Review of the Literature

“…Nonsurgical treatment involving intralesional steroid injection, collagenase clostridium histolyticum injection, anti-inflammatory drugs, radiotherapy, orthoses, stretching, or physical therapy should first be considered. 1,7 There have been several studies demonstrating the effectiveness of radiotherapy, including its capacity to prevent progression of both Dupuytren and Ledderhose disease when applied early in the course. 16 Mella et al have formulated a simplified treatment algorithm incorporating patient-, disease-, and intervention-related factors.…”

“…Partial fasciectomy and wide excision have been shown to produce the lowest recurrence rate. 7 One-centimeter margins of normal aponeurosis are recommended to ensure complete excision of affected fascia and reduce the possibility of relapse. 2 Surgery is not without risks, however, and patients are vulnerable to complications such as skin necrosis, infection, plantar neuroma, and nerve laceration.…”

“…This subset of diseases shares similar symptomatology in different anatomical regions as well as different patient demographics. 7 Further, immunohistochemical and ultrastructural studies have shown that both Ledderhose and Dupuytren diseases share similar fibroblast and myofibroblast composition, suggesting that they are different expressions of the same disorder. 8 Diabetes mellitus, liver disease, alcohol abuse, epilepsy, and repeated trauma have all been frequently described in association with development of lesions in all 3 conditions.…”

“…A recent systematic review of the literature reported a 69.3% recurrence rate after operative intervention. 7 Despite a vast array of options for both conservative and surgical approaches, no gold standard intervention exists. As with Dupuytren disease, a treatment algorithm that factors disease severity, patient preference, and concern for recurrence should be utilized in the management of Ledderhose disease.…”