Current Concepts in Pediatric Obstructive Sleep Apnea

Witmans, Manisha; Tablizo, Mary Anne

doi:10.3390/children10030480

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…This includes both anatomical and neuromuscular disturbances, leading to increased airway resistance and preventing the normal function of the dilator muscles, respectively [5] (Figure 2). OSA is a very frequent condition in children, with prevalence varying between 1 and 4% [6]. Although there has been an effort to increase knowledge about this entity in childhood, there is less scientific evidence than in adults.…”

Section: Etiology Of Osa In Childrenmentioning

confidence: 99%

“…OSA is a very frequent condition in children, with prevalence varying between 1 and 4% [ 6 ]. Although there has been an effort to increase knowledge about this entity in childhood, there is less scientific evidence than in adults.…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, a specific definition, diagnosis, and treatment approach is needed for this specific population. OSA is a very frequent condition in children, with prevalence varying between 1 and 4% [6]. Although there has been an effort to increase knowledge about this entity in childhood, there is less scientific evidence than in adults.…”

Section: Introduction 1definition and Prevalence Of Obstructive Sleep...mentioning

confidence: 99%

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Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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Obstructive sleep apnea (OSA) in children is a prevalent, but still, today, underdiagnosed illness, which consists of repetitive episodes of upper airway obstruction during sleep with important repercussions for sleep quality. OSA has relevant consequences in the pediatric population, mainly in the metabolic, cardiovascular (CV), and neurological spheres. However, contrary to adults, advances in diagnostic and therapeutic management have been scarce in the last few years despite the increasing scientific evidence of the deleterious consequences of pediatric OSA. The problem of underdiagnosis and the lack of response to treatment in some groups make an update to the management of OSA in children necessary. Probably, the heterogeneity of OSA is not well represented by the classical clinical presentation and severity parameters (apnea/hypopnea index (AHI)), and new strategies are required. A specific and consensus definition should be established. Additionally, the role of simplified methods in the diagnosis algorithm should be considered. Finally, the search for new biomarkers for risk stratification is needed in this population. In conclusion, new paradigms based on personalized medicine should be implemented in this population.

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Section: Etiology Of Osa In Childrenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introduction 1definition and Prevalence Of Obstructive Sleep...mentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Solano-Pérez,

Coso,

Castillo-García

et al. 2023

Biomedicines

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Influence of Comorbidity and Obesity on the Occurrence of Vascular Events in Obstructive Apnoea Treated with CPAP

Jurado-Robles,

Jurado-Gámez,

Feu Collado

et al. 2024

Nutrients

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Background: Obesity has increased cardiovascular morbidity and mortality. It is the leading risk factor for obstructive sleep apnoea (OSA). The relationship between obesity-OSA and vascular disease seems clear. There is no consensus on whether CPAP (continuous positive airway pressure) treatment prevents vascular events. Objective: The aim of this study was to determine the effect of comorbidity and obesity on the risk of vascular events in patients with OSA treated with CPAP. Method: This study was a prospective study of historical cohorts of adult patients with OSA and CPAP. The sample was 3017 patients. Descriptive, survival (Kaplan–Meier) and Cox regression analyses were performed, calculating crude and adjusted association relationships to explain the risk of vascular events. Results: A total of 1726 patients were obese, 782 were diabetics, and 1800 were hypertensive. The mean adherence was 6.2 (±1.8 h/day), and the mean follow-up time was 2603 days (±953.3). In the COX regression analysis, the event-related variables were baseline age (HR: 1.025: 1.012–1.037; p < 0.001), pre-treatment vascular event (HR; 2.530: 1.959–3.266; p < 0.001), hypertension (HR; 1.871: 1.187–2.672; p = 0.005) and abbreviated Charlson comorbidity index (HR; 1.289: 1.100–1.510; p = 0.002). Conclusions: The occurrence of vascular events in OSA patients on CPAP treatment is related to hypertension, having a vascular event before treatment, age at the start of CPAP use and abbreviated Charlson comorbidity index.

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Current Concepts in Pediatric Obstructive Sleep Apnea

Abstract: Obstructive sleep apnea (OSA) is described as intermittent partial or complete upper airway obstruction that can disrupt respiratory and ventilatory patterns during sleep [...]

Cited by 2 publications

References 17 publications

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Diagnosis and Treatment of Sleep Apnea in Children: A Future Perspective Is Needed

Influence of Comorbidity and Obesity on the Occurrence of Vascular Events in Obstructive Apnoea Treated with CPAP

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