2020
DOI: 10.3390/metabo10040129
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Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine

Abstract: Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or metabolome) to inform about how a subject will respond to drug treatment. Genome, gut microbiome, sex, nutrition, age, stress, health status, and other factors can impact the metabolic profile of an individual. Some of these factors are known to influence the individual response to pharmaceutical compounds. An individual’s metabolic profile has been referred to as his or her “metabotype.” As such, metabolomic profiles obtain… Show more

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Cited by 72 publications
(80 citation statements)
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“…The opportunity to use perhaps hundreds of analytes for assessment drug pharmacodynamics, or indeed as descriptors of human health and disease, will provide greater accuracy in unraveling the complexity of human biology. Already, metabolomic profiles obtained prior to, during, or after drug treatment are used to provide insights about the drug mechanism of action and variation of response to treatment [ 235 ].…”
Section: Biomarker-based Clinical Studies and Nrf2 Inducersmentioning
confidence: 99%
“…The opportunity to use perhaps hundreds of analytes for assessment drug pharmacodynamics, or indeed as descriptors of human health and disease, will provide greater accuracy in unraveling the complexity of human biology. Already, metabolomic profiles obtained prior to, during, or after drug treatment are used to provide insights about the drug mechanism of action and variation of response to treatment [ 235 ].…”
Section: Biomarker-based Clinical Studies and Nrf2 Inducersmentioning
confidence: 99%
“…The metabolome is directly linked to perturbations in cell metabolism caused by environmental stimuli as well as disease, thus metabolomics has been successfully used to measure phenotypic outcomes in vitro and in vivo [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][40][41][42][43][44][45][46][47][48][49]. Examples include observations of oncometabolites, such as 2-hyroxybutyrate, sarcosine, choline, succinate, lactate, fumarate, and glucose, associated with tumor growth and metastasis that may also function as biomarkers for leukemia, renal carcinoma, breast, brain, or prostate cancer [26][27][28][29][30][31][32].…”
Section: Metabolic Markers In Clinical Studiesmentioning
confidence: 99%
“…Examples include observations of oncometabolites, such as 2-hyroxybutyrate, sarcosine, choline, succinate, lactate, fumarate, and glucose, associated with tumor growth and metastasis that may also function as biomarkers for leukemia, renal carcinoma, breast, brain, or prostate cancer [26][27][28][29][30][31][32]. Metabolomics may also be used to accumulate additional insights during studies of clinical pharmacology and biomarker discovery [3,4,[14][15][16], recognizing that large scale and multi-cohort studies will increase the discovery of candidate biomarkers.…”
Section: Metabolic Markers In Clinical Studiesmentioning
confidence: 99%
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“…As the metabolomics research community finds ways to overcome the current limitations of this powerful technology, this will pave the way be personalized metabolic phenotyping [87,88], which holds great promise in early diagnosis [89], informed treatment choices [90], and accurate prediction of response to therapy [91]. Of note, metabolomics data has advantages as compared to other screening methods as it directly measures drug metabolism, inflammation markers, and other everchanging indicators of the patient's disease status.…”
Section: Integrative Metabolomics-challenges and Emerging Horizonmentioning
confidence: 99%