Current concepts in the clinical management of patients with tinnitus

Parnes, Steven M.

doi:10.1007/bf02439968

Cited by 38 publications

(23 citation statements)

References 23 publications

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“…Jastreboff [36] reported that tinnitus occurred in 85% of patients with ear problems, and 90% of patients with hearing loss were recorded in Parnes' study [24] , but still, some patients complain of tinnitus without obvious hearing loss [37] . However, hearing loss has been consistently associated with tinnitus, and it is generally accepted that 70-80% of deaf people have tinnitus, and only 20-30% do not [5,38] .…”

Section: Discussionmentioning

confidence: 99%

“…Jastreboff and Jastreboff [23] reported that tinnitus affected approximately 17% of the general population and creates a significant problem in approximately 4-5% of them. Parnes [24] reported that as many as 35-45% of the adult population experience tinnitus at some time, but that only 1% of the population suffers from symptoms that are clinically and emotionally distressing.…”

Section: Discussionmentioning

confidence: 99%

“…17), moderate (18)(19)(20)(21)(22)(23)(24) or severe ( 1 25). For depression, mild symptoms equated to a score of 7-17, moderate to 18-24 and severe to 25 or more.…”

Section: Methodsmentioning

confidence: 99%

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Epidemiological Study of Chronic Tinnitus in Assiut, Egypt

et al. 2010

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Background and Aim: Few comprehensive epidemiological studies of the prevalence of tinnitus have been undertaken, and none has been carried out in Egypt. A community-based survey was conducted in the Assiut Governorate to estimate the prevalence of tinnitus, its associations with psychiatric disorders and its effect on the quality of life. Material and Methods: The study involved 8,484 subjects, 5,783 (68.2%) from the rural community and 2,701 (31.8%) from the urban community. Patients were identified from a door-to-door survey and evaluated using a semistructured questionnaire, the Tinnitus Handicap Inventory and the Hamilton Anxiety and Depression Scales. Results: Four hundred and thirty-nine patients with tinnitus were found, giving a prevalence of 5.17 tinnitus cases/100 inhabitants. Males and females were equally affected. The highest age-specific prevalence rate was recorded among subjects above 60 years (17.66%) and was significantly higher among urban than rural inhabitants (6.3 vs. 4.6%) and among illiterate than among educated persons (10.15 vs. 3.07%). A majority of patients (53.3%) had some hearing loss; otitis media was common. Only 15.2% of cases were classified as having severe to catastrophic tinnitus. Nearly two thirds had a degree of depression. There were significant correlations between the severity of tinnitus and the degree of hearing loss, temporomandibular joint pain and the Hamilton depression score. Sleep disturbance was reported by 39.4% of subjects. Life enjoyment was severely affected in 15% of tinnitus patients. Conclusion: Tinnitus is a common problem in our locality, especially in older adults, and is associated with some modifiable risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiological Study of Chronic Tinnitus in Assiut, Egypt

et al. 2010

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“…Current treatments are largely ineffective, with great variability in patient response and risk for significant adverse effects [41,42]. While the pathophysiology is still unclear, it is generally accepted that maladaptive plasticity within auditory circuitry of the CNS is at least, in part, responsible for chronic tinnitus [43].…”

Section: Preclinical and Clinical Studies For Tinnitusmentioning

confidence: 99%

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation

Hays

2016

Neurotherapeutics

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Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

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“…Either on its own or in combination with other auditory or vestibular symptoms (e.g., as in Meniere's disease), tinnitus is a debilitating condition which affects all aspects of life and sometimes even leads to suicide. Parnes (1997) estimated that approximately 1% of the population suffers from chronic tinnitus which causes distress and that 90% of patients with hearing loss experience some tinnitus.…”

Section: Introductionmentioning

confidence: 99%