Current Concepts in the Management of Meconium Aspiration Syndrome

Chettri, Subhash; Bhat, B. Vishnu; Adhisivam, B

doi:10.1007/s12098-016-2128-9

Cited by 37 publications

(30 citation statements)

References 41 publications

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“…On the other side, there is growing evidence of surfactant lavage benefit in both experimental and clinical MAS (Lista et al 2006, Dargaville 2012a, Lin et al 2014 with some authors finding the combination of surfactant lavage and bolus the most effective treatment (Henn et al 2015). This resulted in the fact, that some current national guidelines recommend therapeutic use of exogenous surfactant in severe MAS (Castillo Salinas et al 2015, Chettri et al 2016.…”

Section: Discussionmentioning

confidence: 99%

Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury

Kopincova

Mikolka²,

M³

et al. 2017

Physiol Res

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Meconium aspiration syndrome (MAS) in newborns is characterized mainly by respiratory failure due to surfactant dysfunction and inflammation. Previous meta-analyses did not prove any effect of exogenous surfactant treatment nor glucocorticoid administration on final outcome of children with MAS despite oxygenation improvement. As we supposed there is the need to intervene in both these fields simultaneously, we evaluated therapeutic effect of combination of exogenous surfactant and selective inhibitor of NF-κB (IKK-NBD peptide). Young New Zealand rabbits were instilled by meconium suspension and treated by surfactant alone or surfactant in combination with IKK-NBD, and oxygen-ventilated for 5 h. PaO2/FiO2, oxygenation index, oxygen saturation and ventilation efficiency index were evaluated every hour; post mortem, total and differential leukocyte counts were investigated in bronchoalveolar lavage fluid (BALF) and inflammatory, oxidative and apoptotic markers were assessed in lung tissue homogenates. Exogenous surfactant combined with IKK-NBD improved oxygenation, reduced neutrophil count in BALF and levels of IL-1β, IL-6, p38 MAPK and caspase 3 in comparison with surfactant-only therapy. It seems that inhibition of inflammation may be strong supporting factor in surfactant treatment of MAS.

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Section: Discussionmentioning

confidence: 99%

Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury

Kopincova

Mikolka²,

M³

et al. 2017

Physiol Res

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“…The most common lung conditions that present with respiratory distress are discussed below with different types of assisted ventilation modes and ventilatory settings [ [23] , [24] , [25] , [26] , [27] , [28] ].…”

Section: Suggested Guidelines For the Initial Approach To Mechanical mentioning

confidence: 99%

“Current concepts in assisted mechanical ventilation in the neonate” - Part 2

Chakkarapani

Adappa

Ali

et al. 2020

International Journal of Pediatrics and Adolescent Medicine

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Mechanical ventilation is a lifesaving intervention in critically ill preterm and term neonates. However, it has the potential to cause significant damage to the lungs resulting in long-term complications. Understanding the pathophysiological process and having a good grasp of the basic concepts of conventional and high-frequency ventilation is essential for any medical or allied healthcare practitioner involved in the neonates' respiratory management. This review aims to describe the various types and modes of ventilation usually available in neonatal units. It also describes recommendations of an individualized disease-based approach to mechanical ventilation strategies implemented in the authors' institutions.

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“…Meconium can cause airway obstruction, surfactant dysfunction, chemical pneumonitis and secondary infection. Airway obstruction has been considered to be the primary mechanism of MAS, which can lead to ventilation/perfusion mismatch and air leak (32). Infants with MAS show signs of yellowish or greenish meconium staining on the skin, umbilical cord and nails, and respiratory distress may occur immediately after birth.…”

Section: Meconium Aspiration Syndrome (Mas)mentioning

confidence: 99%

Ultrasound in neonatal lung disease

Liang

Chen

et al. 2018

Quant. Imaging Med. Surg.

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Lung diseases in neonates can be life-threatening condition and may result in respiratory failure and death. Chest X-ray is a traditional diagnostic technique that results in radiation exposure to patients. Lung ultrasound is a user-friendly imaging technique that has been increasingly used in clinical practice in recent years and presents the advantages of real-time imaging and without radiation. Here we review the sonographic appearances of common neonatal lung diseases and present demonstration of typical cases.

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Current Concepts in the Management of Meconium Aspiration Syndrome

Cited by 37 publications

References 41 publications

Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury

Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury

“Current concepts in assisted mechanical ventilation in the neonate” - Part 2

Ultrasound in neonatal lung disease

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