Current concepts of peptic ulceration

Relationship between hydrogen ion concentration and flow of gastric juice during inhibition of gastric secretion in the cat.

“…In conclusion, it should be emphasized that, just as the pathophysiology of peptic ulcer disease is unlikely to be the sole result of the digestive activity of acid and pepsin (Bralow, 1969;Wormsley, 1974), there are also more factors involved in the choice of potential drugs for peptic ulcer therapy than inhibition of gastric acid secretion. Moreover, with the three antagonists studied, their comparative usefulness in ulcer healing is independent of their mechanisms of inhibition of acid secretion which are similar; simple inhibition of the stimulus to cause secretion.…”

Medical Management of Peptic Ulcer With reference to anti-ulcer agents in other gastro-intestinal diseases

“…1951). In the USA, peptic ulcers were the 12th ranking cause of absenteeism and were listed 15th in the causes of death for 1969 (Bralow, 1969). There were 3.5 million persons handicapped each year in the USA and a total financial loss of more than $US 1 billion (Blumenthal, 1968).…”

Role of Phospholipids in Protection of the GI Mucosa

“…In the past, the greatest interest understandably has been in studying the regulation of gastric acid secretion, following the century-old Schwarz's dictum of ''no acid, no ulcer'' [1]. As a consequence, understanding the regulation of gastric acid section and the potential causes of gastric acid hypersecretion became a central research focus until 1970, with major scientific advances including the elucidation of the role of gastrin, acetylcholine, and histamine as physiological stimulants of acid secretion and the identification of luminal acid and somatostatin as physiological inhibitors [2].…”