Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

Chen, Shih Yin; Hsu, Yu-Chin; Lin, Ying; Huang, Yu Chuen; Chen, Chao‐Jung; Lin, Wei; Liao, Wenlin; Chen, Yng Tay; Lin, Wei Yong; Liu, Yu Huei; Yang, Jai Sing; Sheu, Jinn Chyuan; Tsai, Fuu Jen

doi:10.7603/s40681-016-0007-3

Cited by 27 publications

(21 citation statements)

References 71 publications

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“…Risk factors, including poor glycemic control, long duration of diabetes, hypertension, hyperlipidemia and albuminuria, have been found to be associated with DR development (2)(3)(4)(5)(6). Nevertheless, the mechanisms underlying DR have not yet been clarified, and the pathogenesis of the condition is believed to be complex and multifactorial (7).…”

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confidence: 99%

Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development

Huang

Liu

Chen

et al. 2019

In Vivo

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Background/Aim: Diabetic retinopathy (DR) is a type of retinal damage caused by a complication of diabetes and is a major cause of blindness in working-age adults. Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) is a member of the ecto-NOX family involved in the plasma membrane electron transport pathway. This study aimed to investigate the role of ENOX1 in the development of DR. Materials and Methods: Human retinal endothelial cells (HRECs) and human retinal pigment epithelial cells (HREpiCs) exposed to a high concentration (25 mM) of Dglucose and type 2 diabetes (T2D) mice (+Lepr db /+Lepr db , db/db) with retinopathy were used as models to determine the ENOX1 expression levels there. Results: Our results showed that ENOX1 expression levels did not significantly change in both HRECs and HREpiCs under hyperglycemic conditions for 48 h. Nevertheless, ENOX1 expression increased significantly in T2D mouse retinas, particularly in the photoreceptor layer, compared to the control mouse retinas. Conclusion: Different retinal ENOX1 expression in T2D mice and control mice suggested that ENOX1 may be involved in DR development.

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confidence: 99%

Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development

Huang

Liu

Chen

et al. 2019

In Vivo

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“…Current literature suggests that the presence of one pre-existing microvascular complication (retinopathy or nephropathy) may contribute to the development of another 30 31. Retinal vascular geometry can independently predict the incidence of renal dysfunction and may be a useful tool to identify individuals at high risk for renal disease early in the course of type one diabetes (T1D) 32.…”

Section: Discussionmentioning

confidence: 99%

Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy

Hsieh

Huang

Yang

et al. 2020

BMJ Open Diab Res Care

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ObjectiveDiabetic nephropathy (DN) and diabetic retinopathy (DR) comprise major microvascular complications of diabetes that occur with a high concordance rate in patients and are considered to potentially share pathogeneses. In this case-control study, we sought to investigate whether DR-related single nucleotide polymorphisms (SNPs) exert pleiotropic effects on renal function outcomes among patients with diabetes.Research design and methodsA total of 33 DR-related SNPs were identified by replicating published SNPs and via a genome-wide association study. Furthermore, we assessed the cumulative effects by creating a weighted genetic risk score and evaluated the discriminatory and prediction ability of these genetic variants using DN cases according to estimated glomerular filtration rate (eGFR) status along with a cohort with early renal functional decline (ERFD).ResultsMultivariate logistic regression models revealed that the DR-related SNPs afforded no individual or cumulative genetic effect on the nephropathy risk, eGFR status or ERFD outcome among patients with type two diabetes in Taiwan.ConclusionOur findings indicate that larger studies would be necessary to clearly ascertain the effects of individual genetic variants and further investigation is also required to identify other genetic pathways underlying DN.

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“…Diabetes mellitus (DM) is a complex disease that occurs due to absolute or relative insulin deficiency. Lifestyle modifications and nutritional adjustments are some of the best ways to prevent and treat type 2 diabetes mellitus (T2DM) [8] . Notably, genetic factors have also been shown to play an important role in DM and have been suggested as new ways of combating T2DM [8,9] .…”

Section: Ivyspringmentioning

confidence: 99%

“…Lifestyle modifications and nutritional adjustments are some of the best ways to prevent and treat type 2 diabetes mellitus (T2DM) [8] . Notably, genetic factors have also been shown to play an important role in DM and have been suggested as new ways of combating T2DM [8,9] . In this study, we show that CSNK2A1 is involved in the regulation of glucose stimulated insulin secretion (GSIS).…”

Section: Ivyspringmentioning

confidence: 99%

Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity

et al. 2020

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Diabetes mellitus (DM) is a chronic disease found worldwide. Notably, BKS.Cg-Dock7 m +/+ Lepr db /JNarl mice are useful animal models for studying type 2 diabetes mellitus (T2DM). In this study, we investigated casein kinase 2 alpha 1 (CSNK2A1) gene and protein expression in the liver tissues of mice at different ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain reactions, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay. Our data paved the way for exploring BKS.Cg-Dock7 m +/+ Lepr db /JNarl in the mouse model by demonstrating a significant increase in gene and protein expression in T2DM (+Lepr db /+Lepr db) mouse liver when compared to control (+Dock7 m /+Dock7 m) mouse liver. We also observed that CSNK2A1 protein level in the serum of T2DM patient group was higher than that of the control group, although the data was not statistically significant. Based on our findings, we can now understand the role of CSNK2A1 gene upregulation when encountering T2DM pathologies.

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Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

Cited by 27 publications

References 71 publications

Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development

Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development

Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy

Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity

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