Current Concepts Review - Mechanoreceptors in Joint Function*

Hogervorst, Tom; Brand, Richard A.

doi:10.2106/00004623-199809000-00018

Cited by 221 publications

(142 citation statements)

References 120 publications

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“…27 These proprioceptors enable able-bodied humans to know where their hands are in relation to their body without the use of sight. 28 When a limb is lost, these proprioceptors are lost, leading vision to play a stronger role in control than in normal conditions.…”

Section: Discussionmentioning

confidence: 99%

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Roche

Vujaklija

Amsüss

et al. 2015

JoVE

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Advances in robotic systems have resulted in prostheses for the upper limb that can produce multifunctional movements. However, these sophisticated systems require upper limb amputees to learn complex control schemes. Humans have the ability to learn new movements through imitation and other learning strategies. This protocol describes a structured rehabilitation method, which includes imitation, repetition, and reinforcement learning, and aims to assess if this method can improve multifunctional prosthetic control. A left below elbow amputee, with 4 years of experience in prosthetic use, took part in this case study. The prosthesis used was a Michelangelo hand with wrist rotation, and the added features of wrist flexion and extension, which allowed more combinations of hand movements. The participant's Southampton Hand Assessment Procedure score improved from 58 to 71 following structured training. This suggests that a structured training protocol of imitation, repetition and reinforcement may have a role in learning to control a new prosthetic hand. A larger clinical study is however required to support these findings. Video LinkThe video component of this article can be found at

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Section: Discussionmentioning

confidence: 99%

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Roche

Vujaklija

Amsüss

et al. 2015

JoVE

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“…Capsaicin only ablates unmyelinated joint afferents ("nociceptors"), and not myelinated afferents ("mechanoreceptors") [7]. Joint protective reflexes are likely mediated by mechanoreceptors [6]. Consequently, disturbance of protective reflexes may not be the only mechanism involved in the development of osteoarthritic changes.…”

Section: Effects Of Exercise On Joint Degenerutionmentioning

confidence: 99%

Selective joint denervation promotes knee osteoarthritis in the aging rat

Salo

Hogervorst

Seerattan

et al. 2002

Journal Orthopaedic Research

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Osteoarthritis is the most common joint disorder with aging, but its cause is unknown. Mice lose joint afferents with aging, and this loss precedes development of osteoarthritis. We hypothesized a loss of joint afferents is involved in the pathogenesis of osteoarthritis.To test this hypothesis, we denervated knee joints of 16 rats at age 2 months, by intra-articular injection o f an immunotoxin. The imrnunotoxin killed neurons after retrograde axonal transport to the cell body. At 16 or 24 months follow-up, each joint was histologically assessed and assigned an osteoarthritis score.At follow-up, the number of joint afferents had spontaneously decreased by 42% in control knees and 69%~ in denervated knees. We found that control knees developed osteoarthritic changes with aging. However, denervated knees had far more severe changes, as evidenced by a 54% higher average osteoarthritis score than control knees ( P = 0.0016, both groups 16 knees).These results suggest a loss of afferents predisposes a joint to osteoarthritis. We propose the spontaneous loss o f neurons with aging may be a normal developmental process. To explain the mechanism causing osteoarthritis, we suggest denervation permits aberrant joint loading, either by disturbing neuromuscular joint control, or by inducing joint laxity after neurogenic loss of tissue homeostasis.

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“…These receptors include Ruffini, Vater-Pacini, and Golgi-like tension receptors as well as free nerve endings [17,18]. The former three tension receptors are mechanoreceptors that are important in proprioception and provide important signalling pathways during knee postural changes [19].…”

Section: Anatomymentioning

confidence: 99%

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

Shaarani

Moyna

Moran

et al. 2012

ISRN Rehabilitation

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The rehabilitation of patients undergoing anterior cruciate ligament (ACL) reconstruction requires symmetry in bilateral quadriceps strength and adequate proprioception capabilities prior to return to preoperative level of activity or sport. This is the limiting factor and can delay the time that patients can return to play. There is little literature on pre-operative physiotherapy or prehabilitation of patient with ACL injury. This paper discusses the anatomy, biomechanics, surgical decision making, and the current knowledge of preoperative training or "prehabilitation" in patients awaiting ACL reconstruction.

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Current Concepts Review - Mechanoreceptors in Joint Function*

Cited by 221 publications

References 120 publications

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Selective joint denervation promotes knee osteoarthritis in the aging rat

Prehabilitation: The Void in the Management of Anterior Cruciate Ligament Injuries—A Clinical Review

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