Current development of biodegradable polymeric materials for biomedical applications

Song, Richard; Murphy, Maxwell; Li, Chenshuang; Ting, Kang; Soo, Chia; Zheng, Zhong

doi:10.2147/dddt.s165440

Cited by 711 publications

(409 citation statements)

References 252 publications

(402 reference statements)

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“…Polymers have emerged as excellent BTE scaffold materials due to their high biodegradability: they are able to support bone tissue regeneration at the beginning and could be resorbed by the body after new bone tissue generated . Among various types of polymeric scaffolds used for BTE, they can be simply classified as two categories, namely natural polymers and synthetic polymers ( Figure ).…”

Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

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“…Synthetic polymers are important alternative materials to traditional metallic counterparts in orthopedics at low weight‐bearing skeletal sites 6,7. Ultrahigh Molecular Weight Polyethylene (UHMWPE), poly(methylmethacrylate) (PMMA), polyurethanes (PU), and polyetheretherketone (PEEK) are the most commonly used nondegradable polymers approved by United States Food and Drug Administration (US FDA) for orthopedic application,8 while poly( l ‐ or d , l ‐lactic acid), poly(glycolic acid), and polycaprolactones (PCL) are widely used absorbable polymers as orthopedic fixation implants with US FDA approval 6.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg‐based orthopedic implants. First, the properties between Mg‐based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg‐based implants, peri‐implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg‐containing hybrid systems) are discussed to address the limitations of Mg‐based metals prior to their clinical applications at weight‐bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg‐based orthopedic implants are discussed. Taken together, the progress made on the development of Mg‐based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

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“…Therefore, they should be biocompatible, biodegradable at the desired rate, porous, and mechanically stable [6,[9][10][11]. Considering these requirements, the scaffolds based on natural and synthetic polymers alone, as well as composites, exhibit the highest biomedical potential [12][13][14]. Among known biodegradable natural polymers, collagen, gelatin, chitosan, elastin, hyaluronic acid (HA), and silk fibroin are commonly used for TE purposes [15,16].…”

Section: Introduction: the Role Of Proteins And Peptides In Tementioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Current development of biodegradable polymeric materials for biomedical applications

Cited by 711 publications

References 252 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

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