Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities

Nie, Shaoping; Zhang, Hui; Li, Wenjuan; Xie, Mingyong

doi:10.1016/j.bcdf.2013.01.001

Cited by 126 publications

(67 citation statements)

References 104 publications

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“…32,33 More specifically, the antioxidant quality is mainly contributed by the high content of glucans, which has been observed more in GL compared to any other Ganoderma sp. 31,34,35 Besides polysaccharides being the major components, the GL extract also contains proteins and polyphenols; 29,31 however, the higher content of glucan supersedes the content of the former two, and thus it is safe to assume that the excellent reducing ability is mainly due to the polysaccharides (glucans). In addition to glucans, the presence of reducing sugars such as glucose and galactose in the polysaccharide further contributes to its reducing potential.…”

Section: Introductionmentioning

confidence: 99%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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Purpose A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum . Methods The mushroom was boiled in hot water to liberate the polysaccharides, the extract of which was then used directly for the reduction of graphene oxide. The abundance of polysaccharides present in the mushroom serves as a good reducing agent. The proposed strategy evades the use of harmful and expensive chemicals and avoids the typical tedious reaction methods. Results More importantly, the mushroom extract can be easily separated from the product without generating any residual byproducts and can be reused at least three times with good conversion efficiency (75%). It was readily dispersible in water without the need of ultrasonication or any surfactants; whereas 5 minutes of ultrasonication with various solvents produced RGO which was stable for the tested period of 1 year. Based on electrochemical measurements, the followed method did not jeopardize RGO’s electrical conductivity. Moreover, the obtained RGO was highly biocompatible to not only colon (HT-29) and brain (U87MG) cancer cells, but was also viable towards normal cells (MRC-5). Conclusion Besides being eco-friendly, this mushroom based approach is easily scalable and demonstrates remarkable RGO stability and biocompatibility, even without any form of functionalization.

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Section: Introductionmentioning

confidence: 99%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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show abstract

“…G. lucidum polysaccharides and proteoglucans are also reported to prolong the survival of mice with Lewis carcinoma, to increase the excretion of TNF-α and IFN-γ in blood serum in a dose-dependent manner, to stimulate the expression of macrophages and T-cell immunity, to facilitate the recovery of splenic and lymphokine NK cells in immunosuppressed mice, and to exhibit prophylactic activity toward chemically injured macrophages (Ganeshpurkar et al 2010, Nie et al 2013b, Stachowiak and Reguła 2012, You and Lin 2002, Yuen and Gohel 2005.…”

Section: Immunostimulating and Antitumor Propertiesmentioning

confidence: 95%

Fructooligosaccharides in Allium Species: Chemistry and Nutrition

Benkeblia¹

2014

Polysaccharides

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“…Modern pharmacological studies have reported that Lingzhi has a number of pharmacological effects including immune-modulating, anticancer, anti-oxidant, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, antidiabetic, anti-aging, radical-scavenging, neuroprotective, hepatoprotective, and sleep promoting effects [6,7]. Among them, Lingzhi's anti-cancer effect is the most extensively studied.…”

Section: Pharmacological Studiesmentioning

confidence: 99%