Current Developments In Mri For Assessing Rodent Models of Multiple Sclerosis

Alomair, Othman I.; Smith, Maree T.; Brereton, Ian M.; Galloway, Graham J.; Kurniawan, Nyoman D.

doi:10.2217/fnl.14.33

Cited by 2 publications

(2 citation statements)

References 187 publications

(312 reference statements)

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“…Multiple sclerosis (MS) is a chronic inflammatory demyelination disease that causes cognitive, sensory, and motor deterioration to the nervous system [ 1 , 2 ]. Injured myelin undergoes a remyelination process that may fail, and develops chronic plaques with different degrees of demyelination with or without axonal injury and gliosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis

Alghamdi

2023

Brain Sciences

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Diffusion tensor imaging (DTI) showed its adequacy in evaluating the normal-appearing white matter (NAWM) and lesions in the brain that are difficult to evaluate with routine clinical magnetic resonance imaging (MRI) in multiple sclerosis (MS). Recently, MRI systems have been developed with regard to software and hardware, leading to different proposed diffusion analysis methods such as diffusion tensor imaging, q-space imaging, diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and axonal diameter measurement. These methods have the ability to better detect in vivo microstructural changes in the brain than DTI. These different analysis modalities could provide supplementary inputs for MS disease characterization and help in monitoring the disease’s progression as well as treatment efficacy. This paper reviews some of the recent diffusion MRI methods used for the assessment of MS in vivo.

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Section: Introductionmentioning

confidence: 99%

The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis

Alghamdi

2023

Brain Sciences

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“…The role of magnetic resonance imaging (MRI) has been important in multiple sclerosis (MS) research, has assisted the improvement of diagnostic accuracy and in assessing treatment efficacy in clinical trials. Key aspects of MS that can be monitored by MRI include blood brain barrier (BBB) leakage, inflammation, demyelination/ remyelination, axonal injury, and changes in brain connectivity and structural volumes [1][2]. Various experimental animal models have been used to investigate the complex pathobiology of MS [3].…”

Section: Introductionmentioning

confidence: 99%

"Diffusion Weighted Magnetic Resonance Imaging Revealed Changes in the Somatosensory and Motor Cortex of a Mild Relapsing-Remitting Experimental Autoimmune Encephalitis Mouse Model"

Alomair¹,

Khan²,

Smith³

et al. 2021

OAJBS

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Multiple sclerosis (MS) is debilitating disease affecting the central nervous system (CNS). MS pathology has been primarily associated with demyelination and neuroinflammation in the CNS white matter (WM) structures. Recently, clinical studies using high-field magnetic resonance imaging (MRI) have reported diffuse pathological changes observed in the grey matter (GM) regions. This study aims to investigate neurological changes underpinning disease development in mild experimental autoimmune encephalitis (EAE) mouse model of relapsingremitting MS using magnetic resonance diffusion-weighted imaging (DWI). Relapsing-remitting EAE disease was induced in C57BL/6 mice using myelin oligodendrocyte protein (MOG35-55) emulsified in saponin (Quil-A) adjuvant and pertussis toxin. The animal clinical scores were monitored throughout the disease and prior to fixation at acute and chronic relapsing stages. Ex-vivo brain samples were imaged using conventional MRI and DWI at 16.4 Tesla. MRI relaxation and diffusion tensor imaging (DTI) parameters were evaluated to assess structural changes and the results were correlated with BlackGold II myelin staining. Acute EAE mice showed increases in mean and radial diffusivities within WM structures the corpus callosum, external capsule and hippocampal commissure. Chronic EAE mice showed extensive reductions in fractional anisotropy in vital GM structures such as the motor cortex, somatosensory area, and rostral hippocampal regions, as well as in part of the WM anterior cingulate and external capsule. DTI findings were confirmed by a notable reduction in myelin staining and correlated with adverse clinical scores in chronic animals. This study presented for the first time the use of ex-vivo ultra-high-field MRI to detect mild EAE pathology in GM somatosensory and motor cortex using DTI MRI, providing invaluable insight into neuropathological evolution during the relapsing-remitting disease.

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Current Developments In Mri For Assessing Rodent Models of Multiple Sclerosis

Cited by 2 publications

References 187 publications

The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis

The Value of Various Post-Processing Modalities of Diffusion Weighted Imaging in the Detection of Multiple Sclerosis

"Diffusion Weighted Magnetic Resonance Imaging Revealed Changes in the Somatosensory and Motor Cortex of a Mild Relapsing-Remitting Experimental Autoimmune Encephalitis Mouse Model"

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