Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia

Phung, Cao Dai; Tran, Tuan Hiep; Pham, Le Minh; Nguyen, Hanh Thuy; Jeong, Jee–Heon; Yong, Chul Soon; Kim, Jong Oh

doi:10.1016/j.jconrel.2020.05.029

Cited by 94 publications

(48 citation statements)

References 171 publications

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“…Functionalisation of QDs, which shields tissues from their toxic side effects, prompts a more prominent increase in the size of nanoparticles than the pore size of the endothelium and renal vessels, hence lessening its end and causing harm. Additionally, there is no information about the clearance and digestion of QDs in in vivo studies [46][47][48]. Some QDs are illustrated in Table 2, along with their emission ranges and sizes.…”

Section: Quantum Dotsmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Section: Quantum Dotsmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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“…Substantial cellular stress caused by the hypoxic TME promotes the heterogeneity and plasticity of tumors and contributes to the development of more invasive and therapeutically resistant tumor phenotypes [4]. Hypoxia in the TME can enhance the resistance of tumor cells to radiotherapy through promoting DNA self-repairing by cells [8]. Hypoxia is also the primary barrier against the therapeutic efficacy of photodynamic therapy (PDT), as the photosensitizers utilize molecular oxygen to transfer near-infrared laser energy to generate high reactive singlet oxygen and other reactive oxygen species (ROS), which directly or indirectly induces tumor cell apoptosis and/or necrosis [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxia is also the primary barrier against the therapeutic efficacy of photodynamic therapy (PDT), as the photosensitizers utilize molecular oxygen to transfer near-infrared laser energy to generate high reactive singlet oxygen and other reactive oxygen species (ROS), which directly or indirectly induces tumor cell apoptosis and/or necrosis [9,10]. With respect to chemotherapy, hypoxia-induced cell cycle arrest, increased nucleophilic substances, elevated DNA repair enzyme activity, decreased ROS, and reduced sensitivity to p53-mediated apoptosis can either directly or indirectly dampen the efficacy of anticancer agents [8,11]. Moreover, emerging evidence has indicated that hypoxia can cause tumor resistance to immunotherapy by several mechanisms, involving both innate and adaptive immunity.…”

Section: Introductionmentioning

confidence: 99%

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

Wang

Zhao

Zhang

et al. 2021

J Exp Clin Cancer Res

188

137

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With the success of immune checkpoint inhibitors (ICIs), significant progress has been made in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the majority of patients with cancer still do not benefit from this revolutionary therapy. Increasing evidence suggests that one of the major barriers limiting the efficacy of immunotherapy seems to coalesce with the hypoxic tumor microenvironment (TME), which is an intrinsic property of all solid tumors. In addition to its impact on shaping tumor invasion and metastasis, the hypoxic TME plays an essential role in inducing immune suppression and resistance though fostering diverse changes in stromal cell biology. Therefore, targeting hypoxia may provide a means to enhance the efficacy of immunotherapy. In this review, the potential impact of hypoxia within the TME, in terms of key immune cell populations, and the contribution to immune suppression are discussed. In addition, we outline how hypoxia can be manipulated to tailor the immune response and provide a promising combinational therapeutic strategy to improve immunotherapy.

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“…1,2 Hypoxia microenvironment renders cancer cells resistant to cancer treatments, especially for oxygenconsuming therapies, for instance, photodynamic therapy [3][4][5][6] . To enhance the therapeutic efficiency, great efforts have been dedicated to overcoming the bottleneck arising from hypoxia 7 , such as increasing the oxygen concentration, [8][9][10] reducing the oxygen consumption, 11,12 or combining multiple therapeutic methods [13][14][15][16][17][18][19][20] . Nano-delivery systems provide a promising potency in overcoming hypoxia of tumors, but face challenges such as poor repeatability and potentially adverse toxicity.…”

Section: Introductionmentioning

confidence: 99%

Boosting cancer therapy efficiency via photoinduced radical production

Lan

2021

Chem. Sci.

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Current developments in nanotechnology for improved cancer treatment, focusing on tumor hypoxia

Cited by 94 publications

References 171 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy

Boosting cancer therapy efficiency via photoinduced radical production

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