Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications

Chinchilla-Cárdenas, Danny Jair; Cruz-Méndez, Juan Sebastian; Petano-Duque, Julieth Michel; García, Ramón Ovidio; Castro, Lyda R; Lobo-Castañón, María Jesús; Cancino-Escalante, Giovanni Orlando

doi:10.1016/j.jgeb.2024.100400

Journal of Genetic Engineering and Biotechnology

2024

DOI: 10.1016/j.jgeb.2024.100400

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Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications

Danny Jair Chinchilla-Cárdenas,

Juan Sebastian Cruz-Méndez,

Julieth Michel Petano-Duque

et al.

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Cited by 3 publications

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Advances and Future Prospects in Technologies for DNA-Protein Interactions Research

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Advances and Future Prospects in Technologies for DNA-Protein Interactions Research

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Fabrication of a novel electrochemical aptasensor based on conductive polymers and graphite sheet for measuring tetracycline antibiotic in milk, egg, and honey

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2024

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Recent Developments in Aptamer-Based Sensors for Diagnostics

Sheraz,

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et al. 2024

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Chronic and non-communicable diseases (NCDs) account for a large proportion of global disorders and mortality, posing significant burdens on healthcare systems. Early diagnosis and timely interference are critical for effective management and disease prevention. However, the traditional methods of diagnosis still suffer from high costs, time delays in processing, and infrastructure requirements that are usually unaffordable in resource-constrained settings. Aptamer-based biosensors have emerged as promising alternatives to offer enhanced specificity, stability, and cost-effectiveness for disease biomarker detection. The SELEX (Systematic Evolution of Ligands by Exponential Enrichment) methodology allows developing aptamers with high-affinity binding capabilities to a variety of targets, for instance proteins, cells, or even small molecules, hence rendering them suitable for NCD diagnosis. Aptasensors—recent developments in the electrochemical and optical dominion—offer much enhanced sensitivity, selectivity, and stability of detection across a diverse range of diseases from lung cancer and leukemia to diabetes and chronic respiratory disorders. This study provides a comprehensive review of progress in aptamer-based sensors, focusing on their role in point-of-care diagnostics and adaptability in a real-world environment with future directions in overcoming current limitations.

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Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications

Cited by 3 publications

References 177 publications

Advances and Future Prospects in Technologies for DNA-Protein Interactions Research

Advances and Future Prospects in Technologies for DNA-Protein Interactions Research

Fabrication of a novel electrochemical aptasensor based on conductive polymers and graphite sheet for measuring tetracycline antibiotic in milk, egg, and honey

Recent Developments in Aptamer-Based Sensors for Diagnostics

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