Current donor selection strategies for allogeneic hematopoietic cell transplantation

Timofeeva, Olga; Philogene, Mary Carmelle; Zhang, Qiuheng Jennifer

doi:10.1016/j.humimm.2022.08.007

Cited by 17 publications

(6 citation statements)

References 117 publications

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“…A test for DSA is considered positive when mean fluorescence intensity (MFI) is above 1000, and graft failure risk increases significantly when DSA levels are > 5000 MFI at transplant [114]. A thorough review can be found in Timofeeva OA et al [115].…”

Section: Donor Selectionmentioning

confidence: 99%

Transplant Eligible and Ineligible Elderly Patients with AML—A Genomic Approach and Next Generation Questions

Sackstein,

Williams,

Zemel

et al. 2024

Biomedicines

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The management of elderly patients diagnosed with acute myelogenous leukemia (AML) is complicated by high relapse risk and comorbidities that often preclude access to allogeneic hematopoietic cellular transplantation (allo-HCT). In recent years, fast-paced FDA drug approval has reshaped the therapeutic landscape, with modest, albeit promising improvement in survival. Still, AML outcomes in elderly patients remain unacceptably unfavorable highlighting the need for better understanding of disease biology and tailored strategies. In this review, we discuss recent modifications suggested by European Leukemia Network 2022 (ELN-2022) risk stratification and review recent aging cell biology advances with the discussion of four AML cases. While an older age, >60 years, does not constitute an absolute contraindication for allo-HCT, the careful patient selection based on a detailed and multidisciplinary risk stratification cannot be overemphasized.

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Section: Donor Selectionmentioning

confidence: 99%

Transplant Eligible and Ineligible Elderly Patients with AML—A Genomic Approach and Next Generation Questions

Sackstein,

Williams,

Zemel

et al. 2024

Biomedicines

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“…Наше исследование является первой в России работой, в которой изучены мультилокусные HLA-гаплотипы A-B-C-DRB1-DRB3/4/5/-DQA1-DQB1-DPA1-DPB1 на основании типирования 11 HLA-генов. Хотя минимальные требования при подборе неродственного донора для алло-ГСК предписывают HLA-типировать донора и реципиента по четырем HLA-генам -A, -B, -C, -DRB1 [9], определение гена DPB1, в дополнении к генам A, -B, -C, -DRB1 с использованием методов, основанных на секвенировании, настоятельно рекомендуется для всех источников доноров в США [32,34]. Также рекомендуется проводить типирование HLA-генов DRB3/4/5, -DQA1, -DQB1 и -DPA1 (характеризуются более низкой экспрессией) на уровне высокого разрешения для выбора донора наибольшего соответствия и минимизации риска развития донор-специфических анти-HLA антител [34].…”

Section: материалы и методыunclassified

Multilocus HLA haplotypes <i>(A-B-C-DRB1-DRB3/DRB4/DRB5-DQA1-DQB1-DPA1-DPB1)</i> in families of patients scheduled for allogeneic hematopoietic stem cell transplantation

Khamaganova,

Khizhinskiy,

Abdrakhimova

et al. 2023

Med. immunol.

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HLA haplotype is a block of HLA genes located on the same chromosome. Highly polymorphic HLA genes display strong linkage disequilibrium, which results in conserved multilocus HLA haplotypes. Assessment of HLA haplotypic diversity of a specific population is important, particularly for allogeneic hematopoietic stem cell transplantation. Family pedigrees remain the gold standard for studying HLA haplotype segregation. HLA haplotypes, obtained by observations of the segregation of HLA alleles within the family, really exist in the human population. The aim of this work has been to establish the frequencies of HLA haplotypes A-B-C-DRB1-DRB3/DRB4/DRB5-DQA1-DQB1-DPA1-DPB1 in families of patients with assignment to HLA-typing for allogeneic hematopoietic stem cell transplantation. The study included 109 families of patients, in which patients and their potential relative donors of allogeneic hematopoietic stem cell were subjected to HLA-typing. Patients and members of their families were typed by the NGS method in the Laboratory of Tissue Typing at the National Medical Research Center for Hematology for 11 HLA genes – A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1 and DPB1. The genotyping was performed by the NGS method using the AllType NGS 11 Loci Amplification Kits (One Lambda, USA) on the MiSeq sequencing platform (Illumina, USA). The sequences were analyzed using the TypeStream Visual Software (TSV) (One Lambda, USA) and the IPD-IMGT/HLA database 3.44. 360 copies of HLA-haplotypes were found in the studied families. The frequencies of HLA haplotypes were determined by direct counting. The most common 7-locus haplotype was A*01:01-B*08:01-C*07:01-DRB1*03:01-(DRB3*01:01-DQA1*05:01)-DQB1*02:01/163N, the most common 9-locus haplotype was A*03:01-B*07:02-C*07:02-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02-DPA1*01:03-DPB1*04:01P. These HLA haplotypes (in brief, A-B-C-DRB1-DQB1) are the first and second most common HLA haplotypes in most Russian registries of bone marrow donors. Despite several differences, the distribution of HLA haplotypes in families of the patients and in donor registries is similar, and the probability of finding a compatible donor for patients with common HLA-haplotypes in Russian registries is quite high. Most of 7-locus haplotypes are associated with different alleles of the HLA-DP locus in the 9-locus haplotypes, due to presence of a recombination hot spot. The study revealed strong linkage disequilibrium between the HLA alleles DRB1*03:01 and DPB1*01:01P (D’ = 0.579), DRB1*07:01, and DPB1*17:01 (D’ = 0.808), DRB1*09:01 and DPB1*04:02P (D’ = 0.502). The information obtained about real 7- and 9-locus HLA-haplotypes in families may be used in clinical practice as a reference for analyzing the results of HLA-typing and predicting the expected HLA-haplotypes. It has been shown that, despite recombination hot spot between the HLA-DP locus and the rest of the HLA complex, there is strong linkage disequilibrium between some alleles of the DRB1 and DPB1 genes.

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“…17,18 The utilisation of allogeneic stem cells in order to achieve optimal treatment outcomes, it is imperative that the donor cells exhibit a high degree of similarity to the specific type of stem cells present in the recipient patient. 19 In this context, it is worth noting that the giver and the patient share a familial relationship, specifically as siblings or cousins stemming from a common sister or brother. The risk associated with allogenic transplantation is significantly higher when compared to autologous transplantation.…”

Section: Allogenic Transplantationmentioning

confidence: 99%

Leveraging electronic health records and stem cell transplants: a review

Teja,

Gundimeda,

Kolipakula

et al. 2023

Int J Sci Rep

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Biomedical informatics is a burgeoning multidisciplinary field that seeks to optimize the utilization of biomedical data, information, and knowledge for the purposes of scientific research, inquiry, problem-solving, and decision-making, all with the overarching objective of enhancing human health and well-being. Information, informatics, and its applications are used in organ transplantations, such as stem cell transplantation programs, and in programs that directly change disorders. So, many hospitals can maintain EMRs (Electronic medical records), but few are supporting C programs. So, using informatics, we introduced software and programs to run these SCT applications in a very short period of time without any effect.

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Current donor selection strategies for allogeneic hematopoietic cell transplantation

Cited by 17 publications

References 117 publications

Transplant Eligible and Ineligible Elderly Patients with AML—A Genomic Approach and Next Generation Questions

Transplant Eligible and Ineligible Elderly Patients with AML—A Genomic Approach and Next Generation Questions

Multilocus HLA haplotypes <i>(A-B-C-DRB1-DRB3/DRB4/DRB5-DQA1-DQB1-DPA1-DPB1)</i> in families of patients scheduled for allogeneic hematopoietic stem cell transplantation

Leveraging electronic health records and stem cell transplants: a review

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