Current evidence for the use of <i>N</i>‐acetylcysteine following liver resection

Kemp, Richard J.; Mole, Jonathan; Gomez, Dhanny

doi:10.1111/ans.14295

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…Its potential benefit is based on the assumption that NAC has a protective effect on the remnant liver via its mechanism in influencing the ischemia-reperfusion injury (IRI) pathway. Although many centers routinely use NAC postoperatively in patents deemed to be at high risk of developing PHLF, very little data are available to even draw any conclusive evidence for its benefit or otherwise [81].…”

Section: Infectious Complications and Sepsismentioning

confidence: 99%

Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management

Søreide

Deshpande

2021

European Journal of Surgical Oncology

142

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Section: Infectious Complications and Sepsismentioning

confidence: 99%

Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management

Søreide

Deshpande

2021

European Journal of Surgical Oncology

142

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“…In brief, NAC supplementation has exerted favorable effects on vascular health, muscle strength, bone density, cell-mediated immunity, preservation of cognitive function, or marking systemic inflammation [ 49 , 67 , 69 , 70 , 71 , 72 ]. Although positive effects of NAC have been reported for treatments of patients with acute liver failure [ 61 ], other studies on acute liver failure and liver surgery suggest patients randomized to postoperative NAC received no benefit [ 62 , 63 , 64 ]. Finally, NAC is part of the paracetamol formula (acetaminophen).…”

Section: Resultsmentioning

confidence: 99%

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

2018

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This review summarizes recent knowledge about the use of the amino acid l-Cysteine (l-Cys) through diet, nutritional supplements or drugs with the aim to improve human health or treat certain diseases. Three databases (PubMed, Scopus, and Web of Science) and different keywords have been used to create a database of documents published between 1950 and 2017 in scientific journals in English or Spanish. A total of 60,885 primary publications were ultimately selected to compile accurate information about the use of l-Cys in medicine and nutritional therapies and to identify the reported benefits of l-Cys on human health. The number of publications about the use of l-Cys for these purposes has increased significantly during the last two decades. This increase seems to be closely related to the rise of nutraceutical industries and personalized medicine. The main evidence reporting benefits of l-Cys usage is summarized. However, the lack of accurate information and studies based on clinical trials hampers consensus among authors. Thus, the debate about the role and effectiveness of supplements/drugs containing l-Cys is still open.

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“…In the study by Kemp and et al ( 6 ), in 2017, no signiﬁcant improvement in post-operative outcomes with the administration of N-acetylcysteine was reported.…”

Section: Discussionmentioning

confidence: 97%

The Comparison of the Effect of Mannitol and N Acetyl Cysteine on Liver Function in Partial Hepatectomy

et al. 2018

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The alterations in liver function in patients after major liver resection are complex. Partial hepatectomy surgery is considered as a selective therapeutic approach in many benign and malignant liver tumors, secondary metastases, and liver trauma. According to surgical techniques most often based on vascular control and hepatic venous closure (Pringle maneuver), related complications such as ischemia and decreased venous return during and after surgery can be seen. In this study, the effects of Mannitol and N-acetylcysteine, on liver function, after hepatectomy surgery, were compared. This study was shown that infusion N-acetylcysteine next to mannitol, in partial hepatectomy surgeries, was not the significant difference to improve liver function, hemodynamic status, and laboratory tests.

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Current evidence for the use of N‐acetylcysteine following liver resection

Abstract: The current published data do not support the routine use of NAC following liver resection.

Cited by 8 publications

References 41 publications

Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management

Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management

Effects of the Usage of l-Cysteine (l-Cys) on Human Health

The Comparison of the Effect of Mannitol and N Acetyl Cysteine on Liver Function in Partial Hepatectomy

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