Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani, Evangelia; Tsakiridis, Nicole; Kouvelioti, Rozalia; Jaglanian, Alina; Klentrou, Panagiota

doi:10.3390/cancers13112628

Cited by 21 publications

(15 citation statements)

References 103 publications

(202 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of reviews focusing on irisin have been published in the last 10-20 years [37,[43][44][45][46][47][48][49][50]. The influence of exercise on FNDC5 mRNA expression and irisin levels is reviewed previously [43,51].…”

Section: Irisinmentioning

confidence: 99%

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Kornel

Hartogh

Klentrou

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis.

show abstract

Section: Irisinmentioning

confidence: 99%

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Kornel

Hartogh

Klentrou

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Peak concentrations of irisin occurred at 0 h or 1 h after training, and that the increase is transient [4,[10][11][12]. As a result, the half-life of irisin in humans is less than an hour [48]. This is probably why irisin increases after…”

Section: Discussionmentioning

confidence: 99%

Comparative Impact of Various Exercises on Circulating Irisin in Healthy Subjects: A Systematic Review and Network Meta-Analysis

Kazeminasab

Sadeghi

Afshari-Safavi

2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Irisin is a myokine that is secreted from skeletal muscle during exercise and increases lipid metabolism, converting white adipose tissue to brown adipose tissue. Recent studies have shown conflicting results in relation to chronic and acute exercise and irisin. The aim of this study was to evaluate the effects of chronic and acute exercise training on circulating (plasma/serum) irisin level in healthy subjects. We conducted a search of Cochrane Library, PubMed, ISI, Scopus, Embase, and Pedro up to September 2021. A random effects network meta-analysis was performed to calculate the pooled estimate of standardized mean difference (SMD) for acute and chronic exercise effects on irisin level, using Hedge’s g statistic. Of the 16 studies included, six were acute exercise studies (175 participants). The aerobic (Hedge’s g = 0.23 ; 95% CI: -0.58, 1.03) and the anaerobic exercises (Hedge’s g = 0.12 ; 95% CI: -0.45, 0.70) were associated with the increased level of irisin, compared to the control. In the ten chronic exercise studies (433 participants), the resistance training was superior to anaerobic and aerobic training ( P score = 0.632). However, comparing acute and chronic exercise studies, acute training showed the most excellent potential as the best treatment to improve the irisin level ( P score = 0.721). This network meta-analysis showed that acute aerobic exercise has a more effect on irisin levels than acute anaerobic exercise. Also, chronic resistance training has the greatest additive effect on irisin levels compared to chronic aerobic and anaerobic training.

show abstract

“…Irisin was also demonstrated to be a regulator in AMPK, PI3K/AKT, and STAT3/Snail signaling [ 29 ]. Specifically, irisin inhibited proliferation, migration, and invasion, as well as induced apoptosis in cancer cells by inhibiting the PI3K/AKT pathway or stimulating PARP cleavage [ 30 ]. Irisin increased the proliferation of human umbilical vein endothelial cells by promoting the ERK1/2 pathway [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis

et al. 2022

View full text Add to dashboard Cite

Background: Hepatic stellate cells (HSCs) are the central players interacting with multiple cell types in liver fibrosis. The crosstalk between HSCs and macrophages has recently become clearer. Irisin, an exercise-responsive myokine, was known to have a potentially protective role in liver and renal fibrosis, especially in connection with stellate cells. This study investigated the effects of irisin on the interaction between HSCs and macrophages. Methods: Tamm-Horsfall protein-1 (THP-1) human monocytes were differentiated into macrophages, polarized into the inflammatory M1 phenotype with lipopolysaccharide. Lieming Xu-2 (LX-2) cells, human HSCs, were treated with conditioned media (CM) from M1 macrophages, with or without recombinant irisin. HSCs responses to CM from M1 macrophages were evaluated regarding activation, proliferation, wound healing, trans-well migration, contractility, and related signaling pathway. Results: CM from M1 macrophages significantly promoted HSC proliferation, wound healing, transwell migration, and contractility, but not activation of HSCs. Irisin co-treatment attenuated these responses of HSCs to CM. However, CM and irisin treatment did not induce any changes in HSC activation. Further, irisin co-treatment alleviated CM-induced increase of phopho-protein kinase B (pAKT), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinases-1 (TIMP-1). Conclusion: These findings suggested that irisin may play a protective role in the pathogenesis of liver fibrosis, especially when working in the crosstalk between HSCs and macrophages.

show abstract

Current Evidence of the Role of the Myokine Irisin in Cancer

Cited by 21 publications

References 103 publications

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Comparative Impact of Various Exercises on Circulating Irisin in Healthy Subjects: A Systematic Review and Network Meta-Analysis

The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis

Contact Info

Product

Resources

About